Volume 31 Issue 11, November 2013

Volume 31 Issue 11

Volumetric time series of false-colored GFP-histones in a live nematode embryo from the four-cell stage up to hatching. Wu et al. present diSPIM, a four-dimensional imaging method with isotropic resolution and minimal photobleaching (p 1032). Credit: Marina Spence, based on images from Yicong Wu and Hari Shroff.

Editorial

News

Bioentrepreneur

    Building a business

  • Bioentrepreneur |

    Which investment firms are currently actively investing in new biomedical startups?

    • Jonathan Behr
    •  & Phil Murray

Opinion and Comment

Feature

News and Views

  • News & Views |

    Pools of cell lines carrying a variety of known mutations are used to validate the performance of a cancer diagnostic test based on next-generation sequencing.

    • Jason Y Park
    • , Larry J Kricka
    •  & Paolo Fortina
  • News & Views |

    A dual-view light-sheet microscope combines isotropic spatial resolution with high speed and minimal phototoxicity.

    • Carl G Ebeling
    •  & Erik M Jorgensen
  • News & Views |

    A genetically encoded voltage indicator enables robust optical recording of membrane voltage changes in the fly brain.

    • James H Marshel
    •  & Karl Deisseroth

Computational Biology

Research

    Review

  • Articles

  • Article |

    RNA sequencing of 465 human lymphoblastoid cell lines across seven European laboratories shows the feasibility of transcriptome sequencing for population-wide and cross-biobank studies.

    • Peter A C 't Hoen
    • , Marc R Friedländer
    • , Jonas Almlöf
    • , Michael Sammeth
    • , Irina Pulyakhina
    • , Seyed Yahya Anvar
    • , Jeroen F J Laros
    • , Henk P J Buermans
    • , Olof Karlberg
    • , Mathias Brännvall
    • , The GEUVADIS Consortium
    • , Gert-Jan B van Ommen
    • , Xavier Estivill
    • , Roderic Guigó
    • , Ann-Christine Syvänen
    • , Ivo G Gut
    • , Emmanouil T Dermitzakis
    • , Stylianos E Antonarakis
    • , Alvis Brazma
    • , Paul Flicek
    • , Stefan Schreiber
    • , Philip Rosenstiel
    • , Thomas Meitinger
    • , Tim M Strom
    • , Hans Lehrach
    • , Ralf Sudbrak
    • , Angel Carracedo
    • , Peter A C 't Hoen
    • , Irina Pulyakhina
    • , Seyed Yahya Anvar
    • , Jeroen F J Laros
    • , Henk P J Buermans
    • , Maarten van Iterson
    • , Marc R Friedländer
    • , Jean Monlong
    • , Esther Lizano
    • , Gabrielle Bertier
    • , Pedro G Ferreira
    • , Michael Sammeth
    • , Jonas Almlöf
    • , Olof Karlberg
    • , Mathias Brännvall
    • , Paolo Ribeca
    • , Thasso Griebel
    • , Sergi Beltran
    • , Marta Gut
    • , Katja Kahlem
    • , Tuuli Lappalainen
    • , Thomas Giger
    • , Halit Ongen
    • , Ismael Padioleau
    • , Helena Kilpinen
    • , Mar Gonzàlez-Porta
    • , Natalja Kurbatova
    • , Andrew Tikhonov
    • , Liliana Greger
    • , Matthias Barann
    • , Daniela Esser
    • , Robert Häsler
    • , Thomas Wieland
    • , Thomas Schwarzmayr
    • , Marc Sultan
    • , Vyacheslav Amstislavskiy
    • , Johan T den Dunnen
    • , Gert-Jan B van Ommen
    • , Ivo G Gut
    • , Roderic Guigó
    • , Xavier Estivill
    • , Ann-Christine Syvänen
    • , Emmanouil T Dermitzakis
    •  & Tuuli Lappalainen
  • Article |

    Clinical tests that rely on next-generation sequencing to evaluate large numbers of cancer genes can be validated using pooled cell lines with known mutations.

    • Garrett M Frampton
    • , Alex Fichtenholtz
    • , Geoff A Otto
    • , Kai Wang
    • , Sean R Downing
    • , Jie He
    • , Michael Schnall-Levin
    • , Jared White
    • , Eric M Sanford
    • , Peter An
    • , James Sun
    • , Frank Juhn
    • , Kristina Brennan
    • , Kiel Iwanik
    • , Ashley Maillet
    • , Jamie Buell
    • , Emily White
    • , Mandy Zhao
    • , Sohail Balasubramanian
    • , Selmira Terzic
    • , Tina Richards
    • , Vera Banning
    • , Lazaro Garcia
    • , Kristen Mahoney
    • , Zac Zwirko
    • , Amy Donahue
    • , Himisha Beltran
    • , Juan Miguel Mosquera
    • , Mark A Rubin
    • , Snjezana Dogan
    • , Cyrus V Hedvat
    • , Michael F Berger
    • , Lajos Pusztai
    • , Matthias Lechner
    • , Chris Boshoff
    • , Mirna Jarosz
    • , Christine Vietz
    • , Alex Parker
    • , Vincent A Miller
    • , Jeffrey S Ross
    • , John Curran
    • , Maureen T Cronin
    • , Philip J Stephens
    • , Doron Lipson
    •  & Roman Yelensky
  • Article |

    The problem of toxic intermediates in engineered metabolic pathways is mitigated by dynamic gene-expression regulation using stress-responsive promoters.

    • Robert H Dahl
    • , Fuzhong Zhang
    • , Jorge Alonso-Gutierrez
    • , Edward Baidoo
    • , Tanveer S Batth
    • , Alyssa M Redding-Johanson
    • , Christopher J Petzold
    • , Aindrila Mukhopadhyay
    • , Taek Soon Lee
    • , Paul D Adams
    •  & Jay D Keasling

Careers and Recruitment