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Volume 29 Issue 11, November 2011

Cynomolgus macaque (left), also known as the crab-eating macaque, and Chinese rhesus macaque (right). Researchers from The South China Center for Innovative Pharmaceuticals and BGI-Shenzhen have sequenced and compared the genomes of these two biomedically important species (p 1019). Credit: Marina Corral; photos courtesy of Guangmei Yang.

Volume 29 Issue 11

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Editorial

  • The US government's initiative to create a national blueprint for a 21st century bioeconomy is too narrowly drawn. A more expansive vision is needed.

    Editorial

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News

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Data Page

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News Feature

  • Following approval of hepatitis C virus protease inhibitors Incivek and Victrelis, companies are partnering to devise all-oral combination antiviral regimens without interferon α. But the virus is a long way from vanquished. Ken Garber investigates.

    • Ken Garber
    News Feature
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Correspondence

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Commentary

  • Affymetrix was an early mover in the DNA microarray space that came to dominate the market, overcoming criticism from its users and a slew of cutthroat competitors. How did it do it?

    • Victor Bethencourt
    • Christopher Scott
    Commentary
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Patents

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News & Views

  • Comprehensive studies of the kinome set the stage for discovering the next generation of kinase-directed drugs.

    • Chao Zhang
    • Gaston Habets
    • Gideon Bollag
    News & Views

  • Genome sequences are now available for two macaque species used in infectious disease research and drug safety testing.

    • Steven E Bosinger
    • Zachary P Johnson
    • Guido Silvestri
    News & Views

  • Results from the first open-field trial of transgenic mosquitoes bode well for large-scale releases to fight infectious diseases.

    • Todd Shelly
    • Don McInnis
    News & Views
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Research Highlights

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Primer

  • A mathematical concept known as a de Bruijn graph turns the formidable challenge of assembling a contiguous genome from billions of short sequencing reads into a tractable computational problem.

    • Phillip E C Compeau
    • Pavel A Pevzner
    • Glenn Tesler

    Collection:

    Primer
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Perspective

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Article

  • In vivo silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner et al. now show that an optimized lipid nanoparticle delivers siRNA to inflammatory monocytes in mice and, when transporting CCR2 siRNA, has therapeutic effects in cardiovascular disease, cancer and transplant rejection.

    • Florian Leuschner
    • Partha Dutta
    • Matthias Nahrendorf
    Article
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Letter

  • With the cost of DNA sequencing falling rapidly, sample preparation is becoming a bottleneck to surveying genetic variation across large populations or performing clinical diagnostics. Myllykangas et al. present an efficient approach for targeted sequencing in which genomic regions of interest are captured and sequenced inside a flow cell using a common oligonucleotide probe.

    • Samuel Myllykangas
    • Jason D Buenrostro
    • Hanlee P Ji
    Letter

  • Factor Xa would be ideally suited to control unregulated bleeding were it not for its extremely short half-life and tendency to overactivate clotting mechanisms. Ivanciu et al. show that a longer lived but less active variant of the protease restores hemostasis in mouse models of hemophilia without thrombotic complications.

    • Lacramioara Ivanciu
    • Raffaella Toso
    • Rodney M Camire
    Letter

  • Mass-release of sterile male mosquitoes is a promising option for controlling dengue and malaria, but it has never been shown that lab-raised transgenic males can compete effectively with their wild counterparts outside laboratory conditions. Promising results from a restricted field trail now suggest the feasibility of extending the approach for large-scale mosquito-control programs.

    • Angela F Harris
    • Derric Nimmo
    • Luke Alphey
    Letter
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Resource

  • The promiscuity of most kinase inhibitors can cause drug toxicity and complicate the interpretation of experiments. Rather than assessing kinase-compound binding, Anastassiadis et al. use functional assays to profile the activities of 178 commercially available kinase inhibitors against 300 recombinant human protein kinases.

    • Theonie Anastassiadis
    • Sean W Deacon
    • Jeffrey R Peterson
    Resource

  • Davis et al. extend their previous efforts to use inhibitor-kinase interactions to understand kinase inhibitor selectivity by profiling the binding of 72 kinase inhibitors to 442 human kinase catalytic domains. The data reveal group-specific differences in selectivity and suggest the feasibility of developing reasonably specific inhibitors for most kinases.

    • Mindy I Davis
    • Jeremy P Hunt
    • Patrick P Zarrinkar
    Resource
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Careers and Recruitment

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In This Issue

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