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Volume 28 Issue 8, August 2010

A computer-generated representation of HIV on the surface of a T lymphocyte. Holt et al. block the entry of HIV into blood cells by using zinc finger nucleases to knock out CCR5 in hematopoietic stem cells (p 839). Credit: ANIMATE4.com/SciencePhotoLibrary

Volume 28 Issue 8

Editorial

  • With biotech infiltrating multiple industries and fewer life science ventures listing on stock exchanges, what do we really learn from surveying the set of public biotech companies?

    Editorial

    Advertisement

  • The MAQC consortium's latest study suggests that human error in handling DNA microarray data analysis software could delay the technology's wider adoption in the clinic.

    Editorial
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News

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Data Page

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News Feature

  • With monogenetic neurodevelopmental disorders similar to autism serving as starting points for several drug discovery programs, smaller biotechs are now joining big pharma in pursuing therapies to tackle this perplexing condition. Sarah Webb reports.

    • Sarah Webb
    News Feature
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Correspondence

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Commentary

  • By focusing on an unmet medical need, providing a cost-efficient solution and reinvesting the resulting revenues into R&D and state-of-the-art manufacturing, Shantha Biotechnics was able to build one of India's first biotech successes.

    • Justin Chakma
    • Hassan Masum
    • Peter A Singer
    Commentary
  • Restrictive licensing practices on DNA patents are stymieing clinical access and research on genetic diagnostic testing. Diagnostic companies, university tech transfer offices and their respective associations need to pay more attention.

    • Julia Carbone
    • E Richard Gold
    • Robert Cook-Deegan
    Commentary
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Feature

  • The public biotech sector sustained more losses in 2009, but the year ended on a positive note, and the industry has regained its footing.

    • Brady Huggett
    • John Hodgson
    • Riku Lähteenmäki
    Feature
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Patents

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News & Views

  • Transplantation of human hematopoietic stem cells engineered to lack the viral coreceptor CCR5 confers resistance to HIV infection in mice.

    • Steven G Deeks
    • Joseph M McCune
    News & Views
  • The MicroArray Quality Control (MAQC) consortium has evaluated methods for making clinically useful predictions from large-scale gene expression data.

    • Guy W Tillinghast
    News & Views
  • A new method generates genome-scale modified bacteria with unprecedented ease.

    • KA Tipton
    • John Dueber
    News & Views
  • The recent identification of human CD141+ dendritic cells as a counterpart of mouse CD8+ dendritic cells may be useful in developing vaccines and immunotherapies.

    • Hideki Ueno
    • A Karolina Palucka
    • Jacques Banchereau
    News & Views
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Research Highlights

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Analysis

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Article

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Letter

  • Recombinant glycoproteins produced in animal cell lines often bear the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc). Ghaderi et al. show that two monoclonal antibodies in clinical use differ with respect to addition of Neu5Gc and propose that drug developers should consider the consequences of the Neu5Gc modification.

    • Darius Ghaderi
    • Rachel E Taylor
    • Ajit Varki
    Letter
  • Efforts to study ubiquitination have been hampered by the large size of ubiquitin relative to other post-translational modifications. Xu et al. use a monoclonal antibody specific for the adduct left after proteolysis of ubiquitinated proteins to analyze the differential regulation of ubiquitination at distinct sites within the same proteins.

    • Guoqiang Xu
    • Jeremy S Paige
    • Samie R Jaffrey
    Letter
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Careers and Recruitment

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Search

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