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Volume 28 Issue 1, January 2010

Structures of phosphodiesterase 4 in open and closed conformations and several allosteric modulators. Burgin, Gurney and colleagues solve crystal structures of phosphodiesterase 4 bound to ligands and design allosteric modulators with pro-cognitive effects. (p 63)

Volume 28 Issue 1

Editorial

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News

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Q&A

  • Plant scientist Roger Beachy has joined the Obama administration to lead the National Institute of Food and Agriculture (NIFA), the new research funding arm of the US Department of Agriculture (USDA). Beachy, whose research led to the first transgenic crop, was previously the long-time head of the not-for-profit Donald Danforth Plant Science Center in St. Louis. Emily Waltz talks to Beachy about his plans for the new agency.

    • Emily Waltz
    Q&A
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News Feature

  • Cloud computing offers solutions for companies wrestling with large-scale data sets, but security issues will likely continue to restrict its use to precompetitive or nonconfidential data. Clare Sansom reports.

    • Clare Sansom
    News Feature
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Correspondence

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Commentary

  • Clinical trials required by European regulators to compare biosimilar products with corresponding biologic brands are surplus to requirements and may even be a barrier for the development of biosimilars of more complicated biologics.

    • Huub Schellekens
    • Ellen Moors
    Commentary
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Patents

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News & Views

  • Structural insights into the regulation of phosphodiesterase 4 lead to the discovery of allosteric modulators with reduced side effects.

    • Miles D Houslay
    • David R Adams
    News & Views
  • A new metric called the normalized spectral index (SIN) provides a simple way to quantify and compare label-free proteomics data.

    • Mihaela E Sardiu
    • Michael P Washburn
    News & Views
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Research Highlights

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Resource

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Analysis

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Article

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Letter

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Resource

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Careers and Recruitment

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