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Volume 27 Issue 7, July 2009

Sequential therapy of drug-resistant cancers with siRNA- and drug-containing minicells bearing O-polysaccharide chains (yellow). MacDiarmid et al. show that RNAi-mediated silencing of the gene encoding a multidrug resistance protein (magenta) reverses tumor drug resistance, increasing the efficacy of subsequent treatment with cytotoxic drugs (p 643). Credits: Martin Hale, © Animated Biomedical Productions, and Russell Kightley, © Russell Kightley Media.

Volume 27 Issue 7

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Editorial

  • A universal tagging system that links data sets with the author(s) that generated them is essential to promote data sharing within the proteomics and other research communities.

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News Feature

  • Several European countries continue to defy EU law and ban genetically modified maize. Will the stalemate ever be resolved? Gunjan Sinha investigates.

    • Gunjan Sinha
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Correspondence

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Commentary

  • Translation of human pluripotent stem cells into cell therapies will require the development of standardized tests for product consistency, stability, tumorigenicity, toxicity and immunogenicity.

    • Melissa K Carpenter
    • Joyce Frey-Vasconcells
    • Mahendra S Rao
    Commentary
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Patents

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News & Views

  • Bacterially derived minicells loaded with siRNA reverse drug resistance in tumor xenografts.

    • Emmanouil D Karagiannis
    • Daniel G Anderson
    News & Views

  • A multilaboratory study demonstrates the potential for establishing quantitative targeted proteomic assays for moderately to highly abundant plasma proteins.

    • Martin McIntosh
    • Matthew Fitzgibbon
    News & Views

  • A near-infrared fluorescent protein opens a window into the mammalian body.

    • Bradley W Rice
    • Christopher H Contag
    News & Views
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Research Highlights

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Perspective

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Analysis

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Article

  • Lipson et al. profile the yeast transcriptome using single-molecule sequencing. This approach avoids the inherent biases of the digestion, ligation and amplification steps in alternative methods based on microarrays or other sequencing technologies.

    • Doron Lipson
    • Tal Raz
    • Marie Causey
    Article

  • Although combinations of drugs are often more potent than single agents, they are also believed to induce worse side effects. By screening >94,000 drug pairs in vitro, Lehár et al. show that synergistic combinations tend to be more selective than single drugs and are therefore unlikely to cause synergistic side effects.

    • Joseph Lehár
    • Andrew S Krueger
    • Alexis A Borisy
    Article
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