Nature Biotechnology

Volume 26 Issue 4, April 2008

Transmission electron micrograph of pancreatic tissue showing an islet of Langerhans cell (right) containing hormone secretory granules (small blue dots) and an acinar cell (left). Baetge and colleagues (p 443) describe the generation of glucose-responsive insulin-secreting cells from human embryonic stem cells. Credit: Steve Gschmeissner, Science Photo Library.

Volume 26 Issue 4

Editorial

Doing better at doing good

Global health initiatives should place greater emphasis on mechanisms for encouraging small and medium-sized biotech enterprises to participate in the fight against neglected diseases.

Editorial 01 Apr 2008

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A voice with no words

The first blog from a biotech company goes live.

Editorial 01 Apr 2008

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News

US credit crunch impacts biotech across the globe

Peter Mitchell
News 01 Apr 2008
Dynogen's SPAC

Randy Osborne
News 01 Apr 2008
Can 'double blockbuster' strengthen Amgen's backbone?

Cormac Sheridan
News 01 Apr 2008
Four rebuffs for Cabilly

Emily Waltz
News 01 Apr 2008
India's IP snub

KS Jayaraman
News 01 Apr 2008
Companies line up for hereditary angioedema market

Brady Huggett
News 01 Apr 2008
Tear-free onions

Susan Aldridge
News 01 Apr 2008
Thumbs up for Avastin

BJ Spalding
News 01 Apr 2008
Bush tails follow-ons

Jeff Fox
News 01 Apr 2008
Amgen's Japan deal

Mark Ratner
News 01 Apr 2008
Drug makers chase cancer stem cells

Charlie Schmidt
News 01 Apr 2008

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Profile

Dan Ravicher

A patent attorney relies on guts, smarts and 'deep throats' to take on what he considers a broken patent system.

Crispin Littlehales
Profile 01 Apr 2008

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News Feature

A mid-life crisis for aging theory

From yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this process, promise a wealth of new drugs—but the sirtuin hypothesis is now coming under fire. Ken Garber reports.

Ken Garber
News Feature 01 Apr 2008

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Correspondence

An inconvenient version of events

Giovanni Monastra
Correspondence 01 Apr 2008
Response to An inconvenient version of events

Correspondence 01 Apr 2008
Transendothelial movement and caveolae

Richard G W Anderson
Correspondence 01 Apr 2008
Response to Transendothelial movement and caveolae

Correspondence 01 Apr 2008
Expanding YIC status

Philippe Pouletty
Correspondence 01 Apr 2008
Bt corn in Spain—the performance of the EU's first GM crop

Manuel Gómez-Barbero
Julio Berbel
Emilio Rodríguez-Cerezo
Correspondence 01 Apr 2008

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Commentary

Newtons of the leaves of grass

Joachim Boldt
Oliver Müller
Commentary 01 Apr 2008

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Book Review

A bio-friendly future

Linda MacDonald Glenn
Book Review 01 Apr 2008

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Patents

Patenting pluripotence: the next battle for stem cell intellectual property

What will be the impact of induced pluripotent stem cell discoveries on the current stem cell patent landscape?

Katja Triller Vrtovec
Christopher Thomas Scott
Patents 01 Apr 2008
Recent patent applications in drug discovery automation

Patents 01 Apr 2008

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News & Views

Toward a renewable source of pancreatic β-cells

Insulin-producing cells generated from human embryonic stem cells protect mice from diabetes.

Camillo Ricordi
Helena Edlund
News & Views 01 Apr 2008
Targeting siRNA to arrest fibrosis

Vitamin A–mediated targeting of small interfering (si)RNA to stellate cells reverses liver cirrhosis.

Scott L Friedman
News & Views 01 Apr 2008
Cancer biomarker profiling with microRNAs

MicroRNAs define tissues of origin in cancer.

Stefanie S Jeffrey
News & Views 01 Apr 2008
The oldest antibodies newly discovered

Lamprey monoclonal antibodies provide stable and high-avidity alternatives to immunoglobulins.

Zeev Pancer
Roy A Mariuzza
News & Views 01 Apr 2008
siRNAs with guts

Leukocyte-directed, small interfering (si)RNA against cyclin D1 shows promise for treatment of inflammatory bowel disease.

Ian MacLachlan
News & Views 01 Apr 2008
Research highlights

News & Views 01 Apr 2008

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Analysis

Discovering microRNAs from deep sequencing data using miRDeep

Marc R Friedländer
Wei Chen
Nikolaus Rajewsky

Collection:

Computational Biology
Analysis 01 Apr 2008

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Perspective

Making it stick: convection, reaction and diffusion in surface-based biosensors

Todd M Squires
Robert J Messinger
Scott R Manalis
Perspective 07 Apr 2008

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Brief Communication

Detecting native folds in mixtures of proteins that contain disulfide bonds

Mahesh Narayan
Ervin Welker
Harold A Scheraga
Brief Communication 17 Feb 2008

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Article

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

Yasushi Sato
Kazuyuki Murase
Yoshiro Niitsu
Article 30 Mar 2008
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

Evert Kroon
Laura A Martinson
Emmanuel E Baetge

Collection:

25th Anniversary Collection
Article 20 Feb 2008
Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors

Johannes L Zakrzewski
David Suh
Marcel R M van den Brink
Article 30 Mar 2008
MicroRNAs accurately identify cancer tissue origin

Nitzan Rosenfeld
Ranit Aharonov
Iris Barshack
Article 23 Mar 2008

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Erratum

Erratum: Vintage genetic engineering

Laura DeFrancesco
Erratum 01 Apr 2008

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Corrigendum

Correction: Corrigendum: Fluorogen-activating single-chain antibodies for imaging cell surface proteins

Christopher Szent-Gyorgyi
Brigitte A Schmidt
Alan Waggoner
Corrigendum 01 Apr 2008

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Careers and Recruitment

Almost in bloom

St. Louis wants to become a hub of agricultural biotechnology. All it needs is more start-ups and funds.

Emma Marris
Careers and Recruitment 01 Apr 2008

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People

People

People 01 Apr 2008

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