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Volume 26 Issue 12, December 2008

Artist's impression of an integrated blood barcode chip for rapid, multiplexed detection of biomarkers. Fan et al. separate plasma from whole blood in a microfluidic device that captures proteins of interest using antibodies immobilized by DEAL technology and detects them using fluorophore-labeled antibodies (p 1373). Credit: Ken Eward ©BioGrafx.

Volume 26 Issue 12

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Editorial

  • If biotech is to remain a wellspring of innovation, industry and academia need to do more to cultivate the next generation of entrepreneurial minds.

    Editorial

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News

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Profile

  • Alan Alda is not only a beloved actor, producer, writer and activist, but also a skilled science communicator. Those aiming to talk effectively to the public about biotech research would do well to follow his lead.

    • George S Mack
    Profile
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Data Page

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News Feature

  • Two small companies developing therapeutic vaccines against hypertension are blazing a trail for immune treatments that address diseases of lifestyle with massive markets. But doubts linger over the safety of eliciting an immune response to normal body constituents. Jill U. Adams investigates.

    • Jill U. Adams
    News Feature
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Correspondence

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Patents

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News & Views

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Analysis

  • Critical considerations in the design and analysis of ChIP-seq experiments include how to align sequenced tags to the genome, how to detect binding sites and how to estimate the number of tags needed to confidently determine where a protein binds DNA. Using data set for three transcription factors, Kharchenko et al. address these considerations by comparing three novel algorithms with published computational methods.

    • Peter V Kharchenko
    • Michael Y Tolstorukov
    • Peter J Park
    Analysis
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Brief Communication

  • During long-term culture, human embryonic stem (hES) cells may acquire chromosomal abnormalities that compromise their potential clinical utility. A study of 17 hES cell lines reveals various genomic changes, including trisomies and monosomies, an amplification at 20q11.21 and a derivative chromosome 18.

    • Claudia Spits
    • Ileana Mateizel
    • Karen Sermon
    Brief Communication

  • During long-term culture, human embryonic stem (hES) cells may acquire chromosomal abnormalities that compromise their potential clinical utility. Lefort et al. show that an amplification at 20q11.21 arose at relatively late passage number in three of five hES cell lines.

    • Nathalie Lefort
    • Maxime Feyeux
    • Anselme L Perrier
    Brief Communication
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Article

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Letter

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Erratum

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