Volume 23 Issue 2, February 2005

Volume 23 Issue 2

Representation of siRNA and shRNA processing by the RNAse III-family nuclease Dicer. Two papers describe the optimization of RNAi molecules for more efficient gene silencing. (see Kim et al.p. 222 and Siolas et al. p. 227). Graphic by Doug Huff © Arkitek.



  • News |

    The big pharmaceutical companies are increasingly withdrawing from the fight against multidrug-resistant bacteria. Biotech companies have taken a step to replace them but they may not have enough experience of developing new drugs to provide the next generation of antiinfectives.

    • Cormac Sheridan
  • News |

    A new ruling which forces US companies to account for stock options as expenses could penalize biotech companies. Until now, stock options have been an incentive to recruit top managers who would otherwise prefer larger companies.

    • Stacy Lawrence
  • News |

    Increasing reliance on a single gene in growing a variety of crops to make them resistant to bollworms could be dangerous, warn experts. Resistance is looming large among Bt crops in India.

    • K.S. Jayaraman
    • , Jeffrey L. Fox
    • , Hepeng Jia
    •  & Claudia Orellana
  • News |

    In the wake of its accession to the World Trade Organization, China is changing its legislation to open up its market to foreign competition. This could be an opportunity for increased partnering among biotech companies to exploit complementary technologies.

    • Hepeng Jia
    •  & Sabine Louët
  • In Brief

  • News |

    Imagine a world in which biotech could satiate every human desire and correct every human imperfection. Margaret Atwood's latest novel paints a picture and it's not all that rosy.

    • Sabine Louët
  • Data Page

  • News Feature

  • News Feature |

    With the Kyoto treaty demanding reductions in greenhouse gases and the loss of forests outpacing their renewal by natural means, could it be time to start planting genetically engineered forests? Stephan Herrera investigates.

    • Stephan Herrera

Opinion and Comment


News and Views

  • News & Views |

    Two new studies describe strategies for increasing the efficiency of RNA interference.

    • Bryan R.G. Williams
  • News & Views |

    Fragment-based methods for identifying lead compounds are a promising alternative to traditional drug discovery approaches.

    • Harren Jhoti
  • News & Views |

    The genome sequence of the bacterium Gluconobacter oxydans suggests new ways of harnessing this organism's unusual metabolism for biotechnology.

    • Brian McNeil
    •  & Linda Harvey



Computational Biology


    Careers and Recruitment