Volume 23 Issue 10, October 2005

Volume 23 Issue 10

An aggregate of human pancreatic β-cells. The red dye indicates cytoplasmic insulin, and the green dye indicates nuclear Pdx-1. Narushima et al. report a reversible immortalization strategy for generating large numbers of functional human β-cells, (p 1274).



  • News |

    Chiron's ongoing problems in influenza vaccine production have raised serious questions about the company's future ability to compete in this particular segment of the vaccine market.

    • Cormac Sheridan
  • News |

    An important molecule for growth recently received approval in the US. This approval heralds the first medical application of insulin-like growth factor 1 (IGF-1) as a drug to promote growth in a rare group of very small children.

    • Mark Ratner
  • News |

    Under the gun of increased oversight on drug company advertising by the US Food and Drug Administration, the Washington, DC-based industry group Pharmaceutical Research and Manufacturers Association (PhRMA) on 29 July announced a set of guiding principles for ethical practices in direct to consumer advertising (DTC).

    • Alla Katsnelson
  • In Brief

  • News |

    A hands-off philosophy based on investing in people has served Jean Deleage well over almost 35 years of venture capital investing in the life sciences. He reflects on biotech investment trends.

    • Mark Ratner
  • Data Page

  • News Feature

  • News Feature |

    Deep-sea prospecting is unveiling bizarre species of microbes that already are providing new sources of industrial enzymes, and could be a source of novel therapeutics. Will the lack of treaties governing activities in international waters compromise the commercial potential of the ocean's largesse? Cormac Sheridan investigates.

    • Cormac Sheridan

Opinion and Comment


News and Views

  • News & Views |

    A reversibly immortalized human β-cell line may find applications in diabetes therapy and drug screening.

    • Hans E Hohmeier
    •  & Christopher B Newgard
  • News & Views |

    An engineered IgG induces degradation of endogenous IgG, providing a potential therapeutic approach to autoimmune disease.

    • Richard S Blumberg
    •  & Wayne I Lencer
  • News & Views |

    The genome sequence of a dechlorinating bacterium offers new opportunities for bioremediation of chlorinated organic pollutants.

    • Rekha Seshadri
    •  & John Heidelberg
  • News & Views |

    A recent meeting emphasized the importance of integrating concepts from developmental biology and other disciplines into tissue engineering.

    • David L Kaplan
    • , Randall T Moon
    •  & Gordana Vunjak-Novakovic

Computational Biology

Computational Biology




    Careers and Recruitment

  • Careers and Recruitment |

    Reduced side effects and more effective therapies are some of the benefits promised by pharmacogenomics. But to reach these goals, industry will have to marshal a broad range of skills.

    • Ricki Lewis
  • People