Volume 22 Issue 9, September 2004

Volume 22 Issue 9

Representation of the epidermal growth factor receptor (EGFR) pathway HeLa cells. The dynamics of EGFR signaling have been studied using a mass spectrometry-based proteomics method capable of analyzing the phosphoproteome at multiple time points (see Blagoev et al., p. 1139). Photo courtesy of Richard J. Green/Photo Researchers, Inc.



Opinion and Comment


  • Feature |

    Companies that eschew drug discovery in favor of in-licensing have captured a lot of attention and investment over the past few years. But are these young companies really chasing a sustainable business model?

    • Karl A Thiel

News and Views

  • News & Views |

    The temporal dynamics of EGFR signaling has been studied on a broad scale with mass spectrometry.

    • Sam A Johnson
    •  & Tony Hunter
  • News & Views |

    The adult mouse pancreas contains precursor cells able to differentiate toward both pancreatic and neural lineages.

    • Gordon C Weir
    •  & Susan Bonner-Weir
  • News & Views |

    The induction of CD8+ T-cell-mediated immunity against antigens released from normal melanocytes is exploited to destroy metastatic melanomas.

    • Soldano Ferrone
  • News & Views |

    Surface-enhanced resonance Raman scattering enables rapid and sensitive identification of lipase activity and enantioselectivity on dispersed silver nanoparticles.

    • Uwe T Bornscheuer
  • News & Views |

    A calorimetric microarray provides a platform for high-throughput thermodynamic measurements for proteomics and drug screening.

    • F Raymond Salemme




Computational Biology