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Volume 22 Issue 2, February 2004

Representation of a bacteriophage docking on a target molecule in a bacterial membrane. The harnessing of bacteriophage antimicrobial strategies to identify novel bactericidal mechanisms allows the design of assays to screen small molecule libraries for compounds mimicking those effects (see Liu et al., p 185). Electron microscopy images of Staphylococcus aureus phage 77, courtesy of Dr. Hans-Wolfgang Ackermann, Department of Medical Biology, Laval University, Quebec, Canada. Artwork by InViVo Communications Inc. Toronto, Canada.

Volume 22 Issue 2

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  • Immunomodulator CTLA4-Ig was set to be the miracle drug for organ transplantation a dozen years ago, but then faded from view. Now, with startling results in rheumatoid arthritis, costimulatory blockers are on a comeback. Ken Garber reports.

    • Ken Garber
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  • Permissive regulations in a few regions of the world are dictating where human embryonic stem (hES) cell research is taking place, but this could change as numerous countries are still formulating policy.

    • Lori P Knowles
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  • A novel approach for identifying synergistic mixtures of skin penetration enhancers promises to transform development of transdermal products, including patches.

    • Brian W Barry
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  • Rather than using bacteriophage themselves as treatments, a new approach recruits them in the search for antibiotics with new antibacterial mechanisms.

    • Steven Projan
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  • Semiconductor nanocrystals can track movements of individual receptors on the surface of living cells with unmatched spatial and temporal resolution.

    • Gal Gur
    • Yosef Yarden
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  • Gut microbes that cannot be recovered in artificial culture may acquire and harbor genes from genetically modified plants.

    • John Heritage
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  • Liquid crystalline platforms offer fast, simple and inexpensive detection of incoming analytes on two-dimensional fluid biomembrane mimics.

    • Paul S Cremer
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