Reviews & Analysis

Proteome-wide identification of ubiquitination events reveals their functional classes and identifies substrates for ubiquitin ligases.

Transcriptional profiling of single cells in colon tumors may enable prediction of patient outcomes.

Two studies illuminate why genome rearrangements in cancer cells occur where they do.

Genome sequences are now available for two macaque species used in infectious disease research and drug safety testing.

Comprehensive studies of the kinome set the stage for discovering the next generation of kinase-directed drugs.

Results from the first open-field trial of transgenic mosquitoes bode well for large-scale releases to fight infectious diseases.

A mathematical concept known as a de Bruijn graph turns the formidable challenge of assembling a contiguous genome from billions of short sequencing reads into a tractable computational problem.

A new strategy for isolating oligodendrocyte progenitor cells from the human brain may advance the goal of therapeutic remyelination.

A new method to genetically tag RNA for fluorescence imaging in live cells simplifies imaging of cellular RNAs.

Fatigue-resistant, photoswitchable fluorescent proteins facilitate sub-diffraction-limit imaging of living cells with low light intensity.

The convergence of semiconductor chips and DNA sequencing begets a strong contender in the race to build the best sequencers.

Alteration of a stop codon across an entire bacterial genome opens the way to exploring the biotech potential of synthetic genetic codes.

A newly identified surface marker on human embryonic stem cells allows rare tumor-forming cells to be removed from preparations of differentiated cells.

A newly engineered infrared fluorescent protein will allow microscopists to peer more deeply into living animals.

An ancestor of the Chinese hamster ovary cell lines used for production of recombinant therapeutics has been sequenced.

High-resolution linkage analysis enabled by transcriptome sequencing brings order to the genome of a polyploid crop.

A transcriptome can be readily assembled from RNA-Seq data in the absence of a reference genome.

Integrating targeted mass spectrometry into proteomic pipelines speeds the validation of disease biomarkers.