Latest Research

  • Letter |

    An optogenetic study shows that activation of pain-triggering sensory neurons induces an immune response.

    • Frédéric Michoud
    • , Corey Seehus
    • , Philipp Schönle
    • , Noé Brun
    • , Daniel Taub
    • , Zihe Zhang
    • , Aakanksha Jain
    • , Ivan Furfaro
    • , Outman Akouissi
    • , Rachel Moon
    • , Pascale Meier
    • , Katia Galan
    • , Benjamin Doyle
    • , Michael Tetreault
    • , Sébastien Talbot
    • , Liam E. Browne
    • , Qiuting Huang
    • , Clifford J. Woolf
    •  & Stéphanie P. Lacour
  • Letter |

    Testing sewage for the novel coronavirus reveals epidemiological trends.

    • Jordan Peccia
    • , Alessandro Zulli
    • , Doug E. Brackney
    • , Nathan D. Grubaugh
    • , Edward H. Kaplan
    • , Arnau Casanovas-Massana
    • , Albert I. Ko
    • , Amyn A. Malik
    • , Dennis Wang
    • , Mike Wang
    • , Joshua L. Warren
    • , Daniel M. Weinberger
    • , Wyatt Arnold
    •  & Saad B. Omer
  • Article |

    Interaction networks for any protein can be generated using a machine learning algorithm.

    • Joshua Broyde
    • , David R. Simpson
    • , Diana Murray
    • , Evan O. Paull
    • , Brennan W. Chu
    • , Somnath Tagore
    • , Sunny J. Jones
    • , Aaron T. Griffin
    • , Federico M. Giorgi
    • , Alexander Lachmann
    • , Peter Jackson
    • , E. Alejandro Sweet-Cordero
    • , Barry Honig
    •  & Andrea Califano
  • Analysis |

    A comparison of T cell receptor repertoire profiling methods shows substantial differences in their outputs.

    • Pierre Barennes
    • , Valentin Quiniou
    • , Mikhail Shugay
    • , Evgeniy S. Egorov
    • , Alexey N. Davydov
    • , Dmitriy M. Chudakov
    • , Imran Uddin
    • , Mazlina Ismail
    • , Theres Oakes
    • , Benny Chain
    • , Anne Eugster
    • , Karl Kashofer
    • , Peter P. Rainer
    • , Samuel Darko
    • , Amy Ransier
    • , Daniel C. Douek
    • , David Klatzmann
    •  & Encarnita Mariotti-Ferrandiz
  • Brief Communication |

    Gut microbiome composition is associated with phenotypes as revealed by a dimensionality reduction tool.

    • Cameron Martino
    • , Liat Shenhav
    • , Clarisse A. Marotz
    • , George Armstrong
    • , Daniel McDonald
    • , Yoshiki Vázquez-Baeza
    • , James T. Morton
    • , Lingjing Jiang
    • , Maria Gloria Dominguez-Bello
    • , Austin D. Swafford
    • , Eran Halperin
    •  & Rob Knight
  • Article |

    An antibody-based method enables profiling of metabolic protein expression and regulation in single cells using mass spectrometry.

    • Felix J. Hartmann
    • , Dunja Mrdjen
    • , Erin McCaffrey
    • , David R. Glass
    • , Noah F. Greenwald
    • , Anusha Bharadwaj
    • , Zumana Khair
    • , Sanne G. S. Verberk
    • , Alex Baranski
    • , Reema Baskar
    • , William Graf
    • , David Van Valen
    • , Jan Van den Bossche
    • , Michael Angelo
    •  & Sean C. Bendall
  • Article |

    Of 12 serology assays tested, four detect antibodies in more than 80% of patients with COVID-19.

    • Jeffrey D. Whitman
    • , Joseph Hiatt
    • , Cody T. Mowery
    • , Brian R. Shy
    • , Ruby Yu
    • , Tori N. Yamamoto
    • , Ujjwal Rathore
    • , Gregory M. Goldgof
    • , Caroline Whitty
    • , Jonathan M. Woo
    • , Antonia E. Gallman
    • , Tyler E. Miller
    • , Andrew G. Levine
    • , David N. Nguyen
    • , Sagar P. Bapat
    • , Joanna Balcerek
    • , Sophia A. Bylsma
    • , Ana M. Lyons
    • , Stacy Li
    • , Allison Wai-yi Wong
    • , Eva Mae Gillis-Buck
    • , Zachary B. Steinhart
    • , Youjin Lee
    • , Ryan Apathy
    • , Mitchell J. Lipke
    • , Jennifer Anne Smith
    • , Tina Zheng
    • , Ian C. Boothby
    • , Erin Isaza
    • , Jackie Chan
    • , Dante D. Acenas II
    • , Jinwoo Lee
    • , Trisha A. Macrae
    • , Than S. Kyaw
    • , David Wu
    • , Dianna L. Ng
    • , Wei Gu
    • , Vanessa A. York
    • , Haig Alexander Eskandarian
    • , Perri C. Callaway
    • , Lakshmi Warrier
    • , Mary E. Moreno
    • , Justine Levan
    • , Leonel Torres
    • , Lila A. Farrington
    • , Rita P. Loudermilk
    • , Kanishka Koshal
    • , Kelsey C. Zorn
    • , Wilfredo F. Garcia-Beltran
    • , Diane Yang
    • , Michael G. Astudillo
    • , Bradley E. Bernstein
    • , Jeffrey A. Gelfand
    • , Edward T. Ryan
    • , Richelle C. Charles
    • , A. John Iafrate
    • , Jochen K. Lennerz
    • , Steve Miller
    • , Charles Y. Chiu
    • , Susan L. Stramer
    • , Michael R. Wilson
    • , Aashish Manglik
    • , Chun Jimmie Ye
    • , Nevan J. Krogan
    • , Mark S. Anderson
    • , Jason G. Cyster
    • , Joel D. Ernst
    • , Alan H. B. Wu
    • , Kara L. Lynch
    • , Caryn Bern
    • , Patrick D. Hsu
    •  & Alexander Marson
  • Article |

    Combining droplet-based ATAC-seq and mitochondrial DNA sequencing reveals clonal variation in human cells and tissues.

    • Caleb A. Lareau
    • , Leif S. Ludwig
    • , Christoph Muus
    • , Satyen H. Gohil
    • , Tongtong Zhao
    • , Zachary Chiang
    • , Karin Pelka
    • , Jeffrey M. Verboon
    • , Wendy Luo
    • , Elena Christian
    • , Daniel Rosebrock
    • , Gad Getz
    • , Genevieve M. Boland
    • , Fei Chen
    • , Jason D. Buenrostro
    • , Nir Hacohen
    • , Catherine J. Wu
    • , Martin J. Aryee
    • , Aviv Regev
    •  & Vijay G. Sankaran
  • Letter |

    SARS-CoV-2 is reliably detected in nasal swab samples using mass spectrometry and machine learning analysis.

    • Fabiane M. Nachtigall
    • , Alfredo Pereira
    • , Oleksandra S. Trofymchuk
    •  & Leonardo S. Santos
  • Brief Communication |

    Cell clones in lineage-tracing studies can be isolated for functional experiments.

    • Christian Umkehrer
    • , Felix Holstein
    • , Laura Formenti
    • , Julian Jude
    • , Kimon Froussios
    • , Tobias Neumann
    • , Shona M. Cronin
    • , Lisa Haas
    • , Jesse J. Lipp
    • , Thomas R. Burkard
    • , Michaela Fellner
    • , Thomas Wiesner
    • , Johannes Zuber
    •  & Anna C. Obenauf
  • Article |

    A system to express neoantigens in tumor cells and mice circumvents central T cell tolerance.

    • Martina Damo
    • , Brittany Fitzgerald
    • , Yisi Lu
    • , Mursal Nader
    • , Ivana William
    • , Julie F. Cheung
    • , Kelli A. Connolly
    • , Gena G. Foster
    • , Elliot Akama-Garren
    • , Da-Yae Lee
    • , Greg P. Chang
    • , Vasilena Gocheva
    • , Leah M. Schmidt
    • , Alice Boileve
    • , Josephine H. Wilson
    • , Can Cui
    • , Isabel Monroy
    • , Prashanth Gokare
    • , Peter Cabeceiras
    • , Tyler Jacks
    •  & Nikhil S. Joshi
  • Author Correction |

    • Jacob E. Crawford
    • , David W. Clarke
    • , Victor Criswell
    • , Mark Desnoyer
    • , Devon Cornel
    • , Brittany Deegan
    • , Kyle Gong
    • , Kaycie C. Hopkins
    • , Paul Howell
    • , Justin S. Hyde
    • , Josh Livni
    • , Charlie Behling
    • , Renzo Benza
    • , Willa Chen
    • , Karen L. Dobson
    • , Craig Eldershaw
    • , Daniel Greeley
    • , Yi Han
    • , Bridgette Hughes
    • , Evdoxia Kakani
    • , Joe Karbowski
    • , Angus Kitchell
    • , Erika Lee
    • , Teresa Lin
    • , Jianyi Liu
    • , Martin Lozano
    • , Warren MacDonald
    • , James W. Mains
    • , Matty Metlitz
    • , Sara N. Mitchell
    • , David Moore
    • , Johanna R. Ohm
    • , Kathleen Parkes
    • , Alexandra Porshnikoff
    • , Chris Robuck
    • , Martin Sheridan
    • , Robert Sobecki
    • , Peter Smith
    • , Jessica Stevenson
    • , Jordan Sullivan
    • , Brian Wasson
    • , Allison M. Weakley
    • , Mark Wilhelm
    • , Joshua Won
    • , Ari Yasunaga
    • , William C. Chan
    • , Jodi Holeman
    • , Nigel Snoad
    • , Linus Upson
    • , Tiantian Zha
    • , Stephen L. Dobson
    • , F. Steven Mulligan
    • , Peter Massaro
    •  & Bradley J. White
  • Article |

    A blocking assay based on the recombinant receptor-binding domain of SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 receptor provides an alternative to conventional antibody neutralization assays requiring live virus.

    • Chee Wah Tan
    • , Wan Ni Chia
    • , Xijian Qin
    • , Pei Liu
    • , Mark I.-C. Chen
    • , Charles Tiu
    • , Zhiliang Hu
    • , Vivian Chih-Wei Chen
    • , Barnaby E. Young
    • , Wan Rong Sia
    • , Yee-Joo Tan
    • , Randy Foo
    • , Yongxiang Yi
    • , David C. Lye
    • , Danielle E. Anderson
    •  & Lin-Fa Wang
  • Author Correction |

    • Justin M. Zook
    • , Nancy F. Hansen
    • , Nathan D. Olson
    • , Lesley Chapman
    • , James C. Mullikin
    • , Chunlin Xiao
    • , Stephen Sherry
    • , Sergey Koren
    • , Adam M. Phillippy
    • , Paul C. Boutros
    • , Sayed Mohammad E. Sahraeian
    • , Vincent Huang
    • , Alexandre Rouette
    • , Noah Alexander
    • , Christopher E. Mason
    • , Iman Hajirasouliha
    • , Camir Ricketts
    • , Joyce Lee
    • , Rick Tearle
    • , Ian T. Fiddes
    • , Alvaro Martinez Barrio
    • , Jeremiah Wala
    • , Andrew Carroll
    • , Noushin Ghaffari
    • , Oscar L. Rodriguez
    • , Ali Bashir
    • , Shaun Jackman
    • , John J. Farrell
    • , Aaron M. Wenger
    • , Can Alkan
    • , Arda Soylev
    • , Michael C. Schatz
    • , Shilpa Garg
    • , George Church
    • , Tobias Marschall
    • , Ken Chen
    • , Xian Fan
    • , Adam C. English
    • , Jeffrey A. Rosenfeld
    • , Weichen Zhou
    • , Ryan E. Mills
    • , Jay M. Sage
    • , Jennifer R. Davis
    • , Michael D. Kaiser
    • , John S. Oliver
    • , Anthony P. Catalano
    • , Mark J. P. Chaisson
    • , Noah Spies
    • , Fritz J. Sedlazeck
    •  & Marc Salit
  • Brief Communication |

    The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis.

    • Michael A. Skinnider
    • , Jordan W. Squair
    • , Claudia Kathe
    • , Mark A. Anderson
    • , Matthieu Gautier
    • , Kaya J. E. Matson
    • , Marco Milano
    • , Thomas H. Hutson
    • , Quentin Barraud
    • , Aaron A. Phillips
    • , Leonard J. Foster
    • , Gioele La Manno
    • , Ariel J. Levine
    •  & Grégoire Courtine
  • Resource
    | Open Access

    More than 200,000 gut prokaryotic reference genomes and the proteins they encode are collated, providing comprehensive resources for microbiome researchers.

    • Alexandre Almeida
    • , Stephen Nayfach
    • , Miguel Boland
    • , Francesco Strozzi
    • , Martin Beracochea
    • , Zhou Jason Shi
    • , Katherine S. Pollard
    • , Ekaterina Sakharova
    • , Donovan H. Parks
    • , Philip Hugenholtz
    • , Nicola Segata
    • , Nikos C. Kyrpides
    •  & Robert D. Finn
  • Author Correction |

    • Jim Aitken
    • , Karen Ambrose
    • , Sam Barrell
    • , Rupert Beale
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Richard Byrne
    • , Simon Caidan
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Margaret Crawford
    • , Laura Cubitt
    • , Vicky Dearing
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Efthymios Fidanis
    • , Alessandra Gaiba
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Jacki Goldman
    • , Robert Goldstone
    • , Paul R. Grant
    • , Maria Greco
    • , Judith Heaney
    • , Steve Hindmarsh
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Michael Hubank
    • , Deborah Hughes
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Stuart Kirk
    • , Svend Kjaer
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Wei-Ting Lu
    • , James I. MacRae
    • , John Matthews
    • , Laura E. McCoy
    • , Catherine Moore
    • , David Moore
    • , Eleni Nastouli
    • , Jerome Nicod
    • , Luke Nightingale
    • , Jessica Olsen
    • , Nicola O’Reilly
    • , Amar Pabari
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Nigel Peat
    • , Marc Pollitt
    • , Peter Ratcliffe
    • , Caetano Reis e Sousa
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Chloe Roustan
    • , Andrew Rowan
    • , Gee Yen Shin
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Amy Strange
    • , Charles Swanton
    • , James M. A. Turner
    • , Melanie Turner
    • , Andreas Wack
    • , Philip A. Walker
    • , Sophia Ward
    • , Wai Keong Wong
    • , Joshua Wright
    • , Mary Wu
    • , Jim Aitken
    • , Zoe Allen
    • , Rachel Ambler
    • , Karen Ambrose
    • , Emma Ashton
    • , Alida Avola
    • , Samutheswari Balakrishnan
    • , Caitlin Barns-Jenkins
    • , Genevieve Barr
    • , Sam Barrell
    • , Souradeep Basu
    • , Rupert Beale
    • , Clare Beesley
    • , Nisha Bhardwaj
    • , Shahnaz Bibi
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Michael J. Blackman
    • , Dominique Bonnet
    • , Faye Bowker
    • , Malgorzata Broncel
    • , Claire Brooks
    • , Michael D. Buck
    • , Andrew Buckton
    • , Timothy Budd
    • , Alana Burrell
    • , Louise Busby
    • , Claudio Bussi
    • , Simon Butterworth
    • , Fiona Byrne
    • , Richard Byrne
    • , Simon Caidan
    • , Joanna Campbell
    • , Johnathan Canton
    • , Ana Cardoso
    • , Nick Carter
    • , Luiz Carvalho
    • , Raffaella Carzaniga
    • , Natalie Chandler
    • , Qu Chen
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Bobbi Clayton
    • , Clementina Cobolli Gigli
    • , Zena Collins
    • , Sally Cottrell
    • , Margaret Crawford
    • , Laura Cubitt
    • , Tom Cullup
    • , Heledd Davies
    • , Patrick Davis
    • , Dara Davison
    • , Vicky Dearing
    • , Solene Debaisieux
    • , Monica Diaz-Romero
    • , Alison Dibbs
    • , Jessica Diring
    • , Paul C. Driscoll
    • , Annalisa D’Avola
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Dimitrios Evangelopoulos
    • , Rupert Faraway
    • , Antony Fearns
    • , Aaron Ferron
    • , Efthymios Fidanis
    • , James Fleming
    • , Bruno Frederico
    • , Alessandra Gaiba
    • , Anthony Gait
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Liam Gaul
    • , Helen M. Golding
    • , Jacki Goldman
    • , Robert Goldstone
    • , Belen Gomez Dominguez
    • , Hui Gong
    • , Paul R. Grant
    • , Maria Greco
    • , Mariana Grobler
    • , Anabel Guedan
    • , Maximiliano G. Gutierrez
    • , Fiona Hackett
    • , Ross Hall
    • , Steinar Halldorsson
    • , Suzanne Harris
    • , Sugera Hashim
    • , Lyn Healy
    • , Judith Heaney
    • , Susanne Herbst
    • , Graeme Hewitt
    • , Theresa Higgins
    • , Steve Hindmarsh
    • , Rajnika Hirani
    • , Joshua Hope
    • , Elizabeth Horton
    • , Beth Hoskins
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Louise Howitt
    • , Jacqueline Hoyle
    • , Mint R. Htun
    • , Michael Hubank
    • , Hector Huerga Encabo
    • , Deborah Hughes
    • , Jane Hughes
    • , Almaz Huseynova
    • , Ming-Shih Hwang
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Lucy Jenkins
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Louise Kiely
    • , Anastacio King Spert Teixeira
    • , Stuart Kirk
    • , Svend Kjaer
    • , Ellen Knuepfer
    • , Nikita Komarov
    • , Paul Kotzampaltiris
    • , Konstantinos Kousis
    • , Tammy Krylova
    • , Ania Kucharska
    • , Robyn Labrum
    • , Catherine Lambe
    • , Michelle Lappin
    • , Stacey-Ann Lee
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Hon Wing Liu
    • , Sam Loughlin
    • , Wei-Ting Lu
    • , James I. MacRae
    • , Akshay Madoo
    • , Julie A. Marczak
    • , Mimmi Martensson
    • , Thomas Martinez
    • , Bishara Marzook
    • , John Matthews
    • , Joachim M. Matz
    • , Samuel McCall
    • , Laura E. McCoy
    • , Fiona McKay
    • , Edel C. McNamara
    • , Carlos M. Minutti
    • , Gita Mistry
    • , Miriam Molina-Arcas
    • , Beatriz Montaner
    • , Kylie Montgomery
    • , Catherine Moore
    • , David Moore
    • , Anastasia Moraiti
    • , Lucia Moreira-Teixeira
    • , Joyita Mukherjee
    • , Cristina Naceur-Lombardelli
    • , Eleni Nastouli
    • , Aileen Nelson
    • , Jerome Nicod
    • , Luke Nightingale
    • , Stephanie Nofal
    • , Paul Nurse
    • , Savita Nutan
    • , Caroline Oedekoven
    • , Anne O’Garra
    • , Jean D. O’Leary
    • , Jessica Olsen
    • , Olga O’Neill
    • , Nicola O’Reilly
    • , Paula Ordonez Suarez
    • , Neil Osborne
    • , Amar Pabari
    • , Aleksandra Pajak
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Yogen Patel
    • , Oana Paun
    • , Nigel Peat
    • , Laura Peces-Barba Castano
    • , Ana Perez Caballero
    • , Jimena Perez-Lloret
    • , Magali S. Perrault
    • , Abigail Perrin
    • , Roy Poh
    • , Enzo Z. Poirier
    • , James M. Polke
    • , Marc Pollitt
    • , Lucia Prieto-Godino
    • , Alize Proust
    • , Clinda Puvirajasinghe
    • , Christophe Queval
    • , Vijaya Ramachandran
    • , Abhinay Ramaprasad
    • , Peter Ratcliffe
    • , Laura Reed
    • , Caetano Reis e Sousa
    • , Kayleigh Richardson
    • , Sophie Ridewood
    • , Fiona Roberts
    • , Rowenna Roberts
    • , Angela Rodgers
    • , Pablo Romero Clavijo
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Alice Rossi
    • , Chloe Roustan
    • , Andrew Rowan
    • , Erik Sahai
    • , Aaron Sait
    • , Katarzyna Sala
    • , Theo Sanderson
    • , Pierre Santucci
    • , Fatima Sardar
    • , Adam Sateriale
    • , Jill A. Saunders
    • , Chelsea Sawyer
    • , Anja Schlott
    • , Edina Schweighoffer
    • , Sandra Segura-Bayona
    • , Rajvee Shah Punatar
    • , Joe Shaw
    • , Gee Yen Shin
    • , Mariana Silva Dos Santos
    • , Margaux Silvestre
    • , Matthew Singer
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Louisa Steel
    • , Amy Strange
    • , Adrienne E. Sullivan
    • , Charles Swanton
    • , Michele S. Y. Tan
    • , Zoe H. Tautz-Davis
    • , Effie Taylor
    • , Gunes Taylor
    • , Harriet B. Taylor
    • , Alison Taylor-Beadling
    • , Fernanda Teixeira Subtil
    • , Berta Terré Torras
    • , Patrick Toolan-Kerr
    • , Francesca Torelli
    • , Tea Toteva
    • , Moritz Treeck
    • , Hadija Trojer
    • , Ming-Han C. Tsai
    • , James M. A. Turner
    • , Melanie Turner
    • , Jernej Ule
    • , Rachel Ulferts
    • , Sharon P. Vanloo
    • , Selvaraju Veeriah
    • , Subramanian Venkatesan
    • , Karen Vousden
    • , Andreas Wack
    • , Claire Walder
    • , Philip A. Walker
    • , Yiran Wang
    • , Sophia Ward
    • , Catharina Wenman
    • , Luke Williams
    • , Matthew J. Williams
    • , Wai Keong Wong
    • , Joshua Wright
    • , Mary Wu
    • , Lauren Wynne
    • , Zheng Xiang
    • , Melvyn Yap
    • , Julian A. Zagalak
    • , Davide Zecchin
    •  & Rachel Zillwood
  • Article |

    Improved Cas12a variants and sgRNA design rules enhance genome-wide screens.

    • Peter C. DeWeirdt
    • , Kendall R. Sanson
    • , Annabel K. Sangree
    • , Mudra Hegde
    • , Ruth E. Hanna
    • , Marissa N. Feeley
    • , Audrey L. Griffith
    • , Teng Teng
    • , Samantha M. Borys
    • , Christine Strand
    • , J. Keith Joung
    • , Benjamin P. Kleinstiver
    • , Xuewen Pan
    • , Alan Huang
    •  & John G. Doench
  • Article |

    Off-the-shelf CAR T cells avoid immune rejection in mouse models of allogeneic cancer cell therapy.

    • Feiyan Mo
    • , Norihiro Watanabe
    • , Mary K. McKenna
    • , M. John Hicks
    • , Madhuwanti Srinivasan
    • , Diogo Gomes-Silva
    • , Erden Atilla
    • , Tyler Smith
    • , Pinar Ataca Atilla
    • , Royce Ma
    • , David Quach
    • , Helen E. Heslop
    • , Malcolm K. Brenner
    •  & Maksim Mamonkin
  • Letter |

    The activity of adenine or cytosine base editors at specific target nucleotides is predicted computationally.

    • Myungjae Song
    • , Hui Kwon Kim
    • , Sungtae Lee
    • , Younggwang Kim
    • , Sang-Yeon Seo
    • , Jinman Park
    • , Jae Woo Choi
    • , Hyewon Jang
    • , Jeong Hong Shin
    • , Seonwoo Min
    • , Zhejiu Quan
    • , Ji Hun Kim
    • , Hoon Chul Kang
    • , Sungroh Yoon
    •  & Hyongbum Henry Kim
  • Article |

    Water contaminants are detected with freeze-dried, regulated in vitro transcription reactions.

    • Jaeyoung K. Jung
    • , Khalid K. Alam
    • , Matthew S. Verosloff
    • , Daiana A. Capdevila
    • , Morgane Desmau
    • , Phillip R. Clauer
    • , Jeong Wook Lee
    • , Peter Q. Nguyen
    • , Pablo A. Pastén
    • , Sandrine J. Matiasek
    • , Jean-François Gaillard
    • , David P. Giedroc
    • , James J. Collins
    •  & Julius B. Lucks
  • Review Article |

    As CRISPR therapies move into clinical testing, David Schaffer and colleagues review a raft of different delivery technologies being road tested to address cargo capacity limitations, maximize potency, minimize off-target effects and avoid immunogenicity.

    • Joost van Haasteren
    • , Jie Li
    • , Olivia J. Scheideler
    • , Niren Murthy
    •  & David V. Schaffer
  • Article |

    Microscopy datasets are processed orders-of-magnitude faster with improved algorithms and deep learning.

    • Min Guo
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