Latest Research

  • Article |

    Combining droplet-based ATAC-seq and mitochondrial DNA sequencing reveals clonal variation in human cells and tissues.

    • Caleb A. Lareau
    • , Leif S. Ludwig
    • , Christoph Muus
    • , Satyen H. Gohil
    • , Tongtong Zhao
    • , Zachary Chiang
    • , Karin Pelka
    • , Jeffrey M. Verboon
    • , Wendy Luo
    • , Elena Christian
    • , Daniel Rosebrock
    • , Gad Getz
    • , Genevieve M. Boland
    • , Fei Chen
    • , Jason D. Buenrostro
    • , Nir Hacohen
    • , Catherine J. Wu
    • , Martin J. Aryee
    • , Aviv Regev
    •  & Vijay G. Sankaran
  • Letter |

    SARS-CoV-2 is reliably detected in nasal swab samples using mass spectrometry and machine learning analysis.

    • Fabiane M. Nachtigall
    • , Alfredo Pereira
    • , Oleksandra S. Trofymchuk
    •  & Leonardo S. Santos
  • Brief Communication |

    Cell clones in lineage-tracing studies can be isolated for functional experiments.

    • Christian Umkehrer
    • , Felix Holstein
    • , Laura Formenti
    • , Julian Jude
    • , Kimon Froussios
    • , Tobias Neumann
    • , Shona M. Cronin
    • , Lisa Haas
    • , Jesse J. Lipp
    • , Thomas R. Burkard
    • , Michaela Fellner
    • , Thomas Wiesner
    • , Johannes Zuber
    •  & Anna C. Obenauf
  • Article |

    A system to express neoantigens in tumor cells and mice circumvents central T cell tolerance.

    • Martina Damo
    • , Brittany Fitzgerald
    • , Yisi Lu
    • , Mursal Nader
    • , Ivana William
    • , Julie F. Cheung
    • , Kelli A. Connolly
    • , Gena G. Foster
    • , Elliot Akama-Garren
    • , Da-Yae Lee
    • , Greg P. Chang
    • , Vasilena Gocheva
    • , Leah M. Schmidt
    • , Alice Boileve
    • , Josephine H. Wilson
    • , Can Cui
    • , Isabel Monroy
    • , Prashanth Gokare
    • , Peter Cabeceiras
    • , Tyler Jacks
    •  & Nikhil S. Joshi
  • Author Correction |

    • Jacob E. Crawford
    • , David W. Clarke
    • , Victor Criswell
    • , Mark Desnoyer
    • , Devon Cornel
    • , Brittany Deegan
    • , Kyle Gong
    • , Kaycie C. Hopkins
    • , Paul Howell
    • , Justin S. Hyde
    • , Josh Livni
    • , Charlie Behling
    • , Renzo Benza
    • , Willa Chen
    • , Karen L. Dobson
    • , Craig Eldershaw
    • , Daniel Greeley
    • , Yi Han
    • , Bridgette Hughes
    • , Evdoxia Kakani
    • , Joe Karbowski
    • , Angus Kitchell
    • , Erika Lee
    • , Teresa Lin
    • , Jianyi Liu
    • , Martin Lozano
    • , Warren MacDonald
    • , James W. Mains
    • , Matty Metlitz
    • , Sara N. Mitchell
    • , David Moore
    • , Johanna R. Ohm
    • , Kathleen Parkes
    • , Alexandra Porshnikoff
    • , Chris Robuck
    • , Martin Sheridan
    • , Robert Sobecki
    • , Peter Smith
    • , Jessica Stevenson
    • , Jordan Sullivan
    • , Brian Wasson
    • , Allison M. Weakley
    • , Mark Wilhelm
    • , Joshua Won
    • , Ari Yasunaga
    • , William C. Chan
    • , Jodi Holeman
    • , Nigel Snoad
    • , Linus Upson
    • , Tiantian Zha
    • , Stephen L. Dobson
    • , F. Steven Mulligan
    • , Peter Massaro
    •  & Bradley J. White
  • Article |

    A blocking assay based on the recombinant receptor-binding domain of SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 receptor provides an alternative to conventional antibody neutralization assays requiring live virus.

    • Chee Wah Tan
    • , Wan Ni Chia
    • , Xijian Qin
    • , Pei Liu
    • , Mark I.-C. Chen
    • , Charles Tiu
    • , Zhiliang Hu
    • , Vivian Chih-Wei Chen
    • , Barnaby E. Young
    • , Wan Rong Sia
    • , Yee-Joo Tan
    • , Randy Foo
    • , Yongxiang Yi
    • , David C. Lye
    • , Danielle E. Anderson
    •  & Lin-Fa Wang
  • Author Correction |

    • Justin M. Zook
    • , Nancy F. Hansen
    • , Nathan D. Olson
    • , Lesley Chapman
    • , James C. Mullikin
    • , Chunlin Xiao
    • , Stephen Sherry
    • , Sergey Koren
    • , Adam M. Phillippy
    • , Paul C. Boutros
    • , Sayed Mohammad E. Sahraeian
    • , Vincent Huang
    • , Alexandre Rouette
    • , Noah Alexander
    • , Christopher E. Mason
    • , Iman Hajirasouliha
    • , Camir Ricketts
    • , Joyce Lee
    • , Rick Tearle
    • , Ian T. Fiddes
    • , Alvaro Martinez Barrio
    • , Jeremiah Wala
    • , Andrew Carroll
    • , Noushin Ghaffari
    • , Oscar L. Rodriguez
    • , Ali Bashir
    • , Shaun Jackman
    • , John J. Farrell
    • , Aaron M. Wenger
    • , Can Alkan
    • , Arda Soylev
    • , Michael C. Schatz
    • , Shilpa Garg
    • , George Church
    • , Tobias Marschall
    • , Ken Chen
    • , Xian Fan
    • , Adam C. English
    • , Jeffrey A. Rosenfeld
    • , Weichen Zhou
    • , Ryan E. Mills
    • , Jay M. Sage
    • , Jennifer R. Davis
    • , Michael D. Kaiser
    • , John S. Oliver
    • , Anthony P. Catalano
    • , Mark J. P. Chaisson
    • , Noah Spies
    • , Fritz J. Sedlazeck
    •  & Marc Salit
  • Brief Communication |

    The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis.

    • Michael A. Skinnider
    • , Jordan W. Squair
    • , Claudia Kathe
    • , Mark A. Anderson
    • , Matthieu Gautier
    • , Kaya J. E. Matson
    • , Marco Milano
    • , Thomas H. Hutson
    • , Quentin Barraud
    • , Aaron A. Phillips
    • , Leonard J. Foster
    • , Gioele La Manno
    • , Ariel J. Levine
    •  & Grégoire Courtine
  • Resource
    | Open Access

    More than 200,000 gut prokaryotic reference genomes and the proteins they encode are collated, providing comprehensive resources for microbiome researchers.

    • Alexandre Almeida
    • , Stephen Nayfach
    • , Miguel Boland
    • , Francesco Strozzi
    • , Martin Beracochea
    • , Zhou Jason Shi
    • , Katherine S. Pollard
    • , Ekaterina Sakharova
    • , Donovan H. Parks
    • , Philip Hugenholtz
    • , Nicola Segata
    • , Nikos C. Kyrpides
    •  & Robert D. Finn
  • Author Correction |

    • Jim Aitken
    • , Karen Ambrose
    • , Sam Barrell
    • , Rupert Beale
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Richard Byrne
    • , Simon Caidan
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Margaret Crawford
    • , Laura Cubitt
    • , Vicky Dearing
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Efthymios Fidanis
    • , Alessandra Gaiba
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Jacki Goldman
    • , Robert Goldstone
    • , Paul R. Grant
    • , Maria Greco
    • , Judith Heaney
    • , Steve Hindmarsh
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Michael Hubank
    • , Deborah Hughes
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Stuart Kirk
    • , Svend Kjaer
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Wei-Ting Lu
    • , James I. MacRae
    • , John Matthews
    • , Laura E. McCoy
    • , Catherine Moore
    • , David Moore
    • , Eleni Nastouli
    • , Jerome Nicod
    • , Luke Nightingale
    • , Jessica Olsen
    • , Nicola O’Reilly
    • , Amar Pabari
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Nigel Peat
    • , Marc Pollitt
    • , Peter Ratcliffe
    • , Caetano Reis e Sousa
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Chloe Roustan
    • , Andrew Rowan
    • , Gee Yen Shin
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Amy Strange
    • , Charles Swanton
    • , James M. A. Turner
    • , Melanie Turner
    • , Andreas Wack
    • , Philip A. Walker
    • , Sophia Ward
    • , Wai Keong Wong
    • , Joshua Wright
    • , Mary Wu
    • , Jim Aitken
    • , Zoe Allen
    • , Rachel Ambler
    • , Karen Ambrose
    • , Emma Ashton
    • , Alida Avola
    • , Samutheswari Balakrishnan
    • , Caitlin Barns-Jenkins
    • , Genevieve Barr
    • , Sam Barrell
    • , Souradeep Basu
    • , Rupert Beale
    • , Clare Beesley
    • , Nisha Bhardwaj
    • , Shahnaz Bibi
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Michael J. Blackman
    • , Dominique Bonnet
    • , Faye Bowker
    • , Malgorzata Broncel
    • , Claire Brooks
    • , Michael D. Buck
    • , Andrew Buckton
    • , Timothy Budd
    • , Alana Burrell
    • , Louise Busby
    • , Claudio Bussi
    • , Simon Butterworth
    • , Fiona Byrne
    • , Richard Byrne
    • , Simon Caidan
    • , Joanna Campbell
    • , Johnathan Canton
    • , Ana Cardoso
    • , Nick Carter
    • , Luiz Carvalho
    • , Raffaella Carzaniga
    • , Natalie Chandler
    • , Qu Chen
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Bobbi Clayton
    • , Clementina Cobolli Gigli
    • , Zena Collins
    • , Sally Cottrell
    • , Margaret Crawford
    • , Laura Cubitt
    • , Tom Cullup
    • , Heledd Davies
    • , Patrick Davis
    • , Dara Davison
    • , Vicky Dearing
    • , Solene Debaisieux
    • , Monica Diaz-Romero
    • , Alison Dibbs
    • , Jessica Diring
    • , Paul C. Driscoll
    • , Annalisa D’Avola
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Dimitrios Evangelopoulos
    • , Rupert Faraway
    • , Antony Fearns
    • , Aaron Ferron
    • , Efthymios Fidanis
    • , James Fleming
    • , Bruno Frederico
    • , Alessandra Gaiba
    • , Anthony Gait
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Liam Gaul
    • , Helen M. Golding
    • , Jacki Goldman
    • , Robert Goldstone
    • , Belen Gomez Dominguez
    • , Hui Gong
    • , Paul R. Grant
    • , Maria Greco
    • , Mariana Grobler
    • , Anabel Guedan
    • , Maximiliano G. Gutierrez
    • , Fiona Hackett
    • , Ross Hall
    • , Steinar Halldorsson
    • , Suzanne Harris
    • , Sugera Hashim
    • , Lyn Healy
    • , Judith Heaney
    • , Susanne Herbst
    • , Graeme Hewitt
    • , Theresa Higgins
    • , Steve Hindmarsh
    • , Rajnika Hirani
    • , Joshua Hope
    • , Elizabeth Horton
    • , Beth Hoskins
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Louise Howitt
    • , Jacqueline Hoyle
    • , Mint R. Htun
    • , Michael Hubank
    • , Hector Huerga Encabo
    • , Deborah Hughes
    • , Jane Hughes
    • , Almaz Huseynova
    • , Ming-Shih Hwang
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Lucy Jenkins
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Louise Kiely
    • , Anastacio King Spert Teixeira
    • , Stuart Kirk
    • , Svend Kjaer
    • , Ellen Knuepfer
    • , Nikita Komarov
    • , Paul Kotzampaltiris
    • , Konstantinos Kousis
    • , Tammy Krylova
    • , Ania Kucharska
    • , Robyn Labrum
    • , Catherine Lambe
    • , Michelle Lappin
    • , Stacey-Ann Lee
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Hon Wing Liu
    • , Sam Loughlin
    • , Wei-Ting Lu
    • , James I. MacRae
    • , Akshay Madoo
    • , Julie A. Marczak
    • , Mimmi Martensson
    • , Thomas Martinez
    • , Bishara Marzook
    • , John Matthews
    • , Joachim M. Matz
    • , Samuel McCall
    • , Laura E. McCoy
    • , Fiona McKay
    • , Edel C. McNamara
    • , Carlos M. Minutti
    • , Gita Mistry
    • , Miriam Molina-Arcas
    • , Beatriz Montaner
    • , Kylie Montgomery
    • , Catherine Moore
    • , David Moore
    • , Anastasia Moraiti
    • , Lucia Moreira-Teixeira
    • , Joyita Mukherjee
    • , Cristina Naceur-Lombardelli
    • , Eleni Nastouli
    • , Aileen Nelson
    • , Jerome Nicod
    • , Luke Nightingale
    • , Stephanie Nofal
    • , Paul Nurse
    • , Savita Nutan
    • , Caroline Oedekoven
    • , Anne O’Garra
    • , Jean D. O’Leary
    • , Jessica Olsen
    • , Olga O’Neill
    • , Nicola O’Reilly
    • , Paula Ordonez Suarez
    • , Neil Osborne
    • , Amar Pabari
    • , Aleksandra Pajak
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Yogen Patel
    • , Oana Paun
    • , Nigel Peat
    • , Laura Peces-Barba Castano
    • , Ana Perez Caballero
    • , Jimena Perez-Lloret
    • , Magali S. Perrault
    • , Abigail Perrin
    • , Roy Poh
    • , Enzo Z. Poirier
    • , James M. Polke
    • , Marc Pollitt
    • , Lucia Prieto-Godino
    • , Alize Proust
    • , Clinda Puvirajasinghe
    • , Christophe Queval
    • , Vijaya Ramachandran
    • , Abhinay Ramaprasad
    • , Peter Ratcliffe
    • , Laura Reed
    • , Caetano Reis e Sousa
    • , Kayleigh Richardson
    • , Sophie Ridewood
    • , Fiona Roberts
    • , Rowenna Roberts
    • , Angela Rodgers
    • , Pablo Romero Clavijo
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Alice Rossi
    • , Chloe Roustan
    • , Andrew Rowan
    • , Erik Sahai
    • , Aaron Sait
    • , Katarzyna Sala
    • , Theo Sanderson
    • , Pierre Santucci
    • , Fatima Sardar
    • , Adam Sateriale
    • , Jill A. Saunders
    • , Chelsea Sawyer
    • , Anja Schlott
    • , Edina Schweighoffer
    • , Sandra Segura-Bayona
    • , Rajvee Shah Punatar
    • , Joe Shaw
    • , Gee Yen Shin
    • , Mariana Silva Dos Santos
    • , Margaux Silvestre
    • , Matthew Singer
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Louisa Steel
    • , Amy Strange
    • , Adrienne E. Sullivan
    • , Charles Swanton
    • , Michele S. Y. Tan
    • , Zoe H. Tautz-Davis
    • , Effie Taylor
    • , Gunes Taylor
    • , Harriet B. Taylor
    • , Alison Taylor-Beadling
    • , Fernanda Teixeira Subtil
    • , Berta Terré Torras
    • , Patrick Toolan-Kerr
    • , Francesca Torelli
    • , Tea Toteva
    • , Moritz Treeck
    • , Hadija Trojer
    • , Ming-Han C. Tsai
    • , James M. A. Turner
    • , Melanie Turner
    • , Jernej Ule
    • , Rachel Ulferts
    • , Sharon P. Vanloo
    • , Selvaraju Veeriah
    • , Subramanian Venkatesan
    • , Karen Vousden
    • , Andreas Wack
    • , Claire Walder
    • , Philip A. Walker
    • , Yiran Wang
    • , Sophia Ward
    • , Catharina Wenman
    • , Luke Williams
    • , Matthew J. Williams
    • , Wai Keong Wong
    • , Joshua Wright
    • , Mary Wu
    • , Lauren Wynne
    • , Zheng Xiang
    • , Melvyn Yap
    • , Julian A. Zagalak
    • , Davide Zecchin
    •  & Rachel Zillwood
  • Article |

    Improved Cas12a variants and sgRNA design rules enhance genome-wide screens.

    • Peter C. DeWeirdt
    • , Kendall R. Sanson
    • , Annabel K. Sangree
    • , Mudra Hegde
    • , Ruth E. Hanna
    • , Marissa N. Feeley
    • , Audrey L. Griffith
    • , Teng Teng
    • , Samantha M. Borys
    • , Christine Strand
    • , J. Keith Joung
    • , Benjamin P. Kleinstiver
    • , Xuewen Pan
    • , Alan Huang
    •  & John G. Doench
  • Article |

    Off-the-shelf CAR T cells avoid immune rejection in mouse models of allogeneic cancer cell therapy.

    • Feiyan Mo
    • , Norihiro Watanabe
    • , Mary K. McKenna
    • , M. John Hicks
    • , Madhuwanti Srinivasan
    • , Diogo Gomes-Silva
    • , Erden Atilla
    • , Tyler Smith
    • , Pinar Ataca Atilla
    • , Royce Ma
    • , David Quach
    • , Helen E. Heslop
    • , Malcolm K. Brenner
    •  & Maksim Mamonkin
  • Letter |

    The activity of adenine or cytosine base editors at specific target nucleotides is predicted computationally.

    • Myungjae Song
    • , Hui Kwon Kim
    • , Sungtae Lee
    • , Younggwang Kim
    • , Sang-Yeon Seo
    • , Jinman Park
    • , Jae Woo Choi
    • , Hyewon Jang
    • , Jeong Hong Shin
    • , Seonwoo Min
    • , Zhejiu Quan
    • , Ji Hun Kim
    • , Hoon Chul Kang
    • , Sungroh Yoon
    •  & Hyongbum Henry Kim
  • Article |

    Water contaminants are detected with freeze-dried, regulated in vitro transcription reactions.

    • Jaeyoung K. Jung
    • , Khalid K. Alam
    • , Matthew S. Verosloff
    • , Daiana A. Capdevila
    • , Morgane Desmau
    • , Phillip R. Clauer
    • , Jeong Wook Lee
    • , Peter Q. Nguyen
    • , Pablo A. Pastén
    • , Sandrine J. Matiasek
    • , Jean-François Gaillard
    • , David P. Giedroc
    • , James J. Collins
    •  & Julius B. Lucks
  • Review Article |

    As CRISPR therapies move into clinical testing, David Schaffer and colleagues review a raft of different delivery technologies being road tested to address cargo capacity limitations, maximize potency, minimize off-target effects and avoid immunogenicity.

    • Joost van Haasteren
    • , Jie Li
    • , Olivia J. Scheideler
    • , Niren Murthy
    •  & David V. Schaffer
  • Article |

    Microscopy datasets are processed orders-of-magnitude faster with improved algorithms and deep learning.

    • Min Guo
    • , Yue Li
    • , Yijun Su
    • , Talley Lambert
    • , Damian Dalle Nogare
    • , Mark W. Moyle
    • , Leighton H. Duncan
    • , Richard Ikegami
    • , Anthony Santella
    • , Ivan Rey-Suarez
    • , Daniel Green
    • , Anastasia Beiriger
    • , Jiji Chen
    • , Harshad Vishwasrao
    • , Sundar Ganesan
    • , Victoria Prince
    • , Jennifer C. Waters
    • , Christina M. Annunziata
    • , Markus Hafner
    • , William A. Mohler
    • , Ajay B. Chitnis
    • , Arpita Upadhyaya
    • , Ted B. Usdin
    • , Zhirong Bao
    • , Daniel Colón-Ramos
    • , Patrick La Riviere
    • , Huafeng Liu
    • , Yicong Wu
    •  & Hari Shroff
  • Article |

    Transient p53 inhibition and induced cell-cycle progression increase clonal engraftment and homology-directed repair in hematopoietic stem cells.

    • Samuele Ferrari
    • , Aurelien Jacob
    • , Stefano Beretta
    • , Giulia Unali
    • , Luisa Albano
    • , Valentina Vavassori
    • , Davide Cittaro
    • , Dejan Lazarevic
    • , Chiara Brombin
    • , Federica Cugnata
    • , Anna Kajaste-Rudnitski
    • , Ivan Merelli
    • , Pietro Genovese
    •  & Luigi Naldini
  • Article |

    Single-cell analysis of COVID-19 patient samples identifies activated immune pathways that correlate with severe disease.

    • Robert Lorenz Chua
    • , Soeren Lukassen
    • , Saskia Trump
    • , Bianca P. Hennig
    • , Daniel Wendisch
    • , Fabian Pott
    • , Olivia Debnath
    • , Loreen Thürmann
    • , Florian Kurth
    • , Maria Theresa Völker
    • , Julia Kazmierski
    • , Bernd Timmermann
    • , Sven Twardziok
    • , Stefan Schneider
    • , Felix Machleidt
    • , Holger Müller-Redetzky
    • , Melanie Maier
    • , Alexander Krannich
    • , Sein Schmidt
    • , Felix Balzer
    • , Johannes Liebig
    • , Jennifer Loske
    • , Norbert Suttorp
    • , Jürgen Eils
    • , Naveed Ishaque
    • , Uwe Gerd Liebert
    • , Christof von Kalle
    • , Andreas Hocke
    • , Martin Witzenrath
    • , Christine Goffinet
    • , Christian Drosten
    • , Sven Laudi
    • , Irina Lehmann
    • , Christian Conrad
    • , Leif-Erik Sander
    •  & Roland Eils
  • Resource |

    Detection of structural variants in the human genome is facilitated by a benchmark set of large deletions and insertions.

    • Justin M. Zook
    • , Nancy F. Hansen
    • , Nathan D. Olson
    • , Lesley Chapman
    • , James C. Mullikin
    • , Chunlin Xiao
    • , Stephen Sherry
    • , Sergey Koren
    • , Adam M. Phillippy
    • , Paul C. Boutros
    • , Sayed Mohammad E. Sahraeian
    • , Vincent Huang
    • , Alexandre Rouette
    • , Noah Alexander
    • , Christopher E. Mason
    • , Iman Hajirasouliha
    • , Camir Ricketts
    • , Joyce Lee
    • , Rick Tearle
    • , Ian T. Fiddes
    • , Alvaro Martinez Barrio
    • , Jeremiah Wala
    • , Andrew Carroll
    • , Noushin Ghaffari
    • , Oscar L. Rodriguez
    • , Ali Bashir
    • , Shaun Jackman
    • , John J. Farrell
    • , Aaron M. Wenger
    • , Can Alkan
    • , Arda Soylev
    • , Michael C. Schatz
    • , Shilpa Garg
    • , George Church
    • , Tobias Marschall
    • , Ken Chen
    • , Xian Fan
    • , Adam C. English
    • , Jeffrey A. Rosenfeld
    • , Weichen Zhou
    • , Ryan E. Mills
    • , Jay M. Sage
    • , Jennifer R. Davis
    • , Michael D. Kaiser
    • , John S. Oliver
    • , Anthony P. Catalano
    • , Mark J. P. Chaisson
    • , Noah Spies
    • , Fritz J. Sedlazeck
    •  & Marc Salit
  • Article |

    Gut microbiome composition is remodeled using small peptides.

    • Poshen B. Chen
    • , Audrey S. Black
    • , Adam L. Sobel
    • , Yannan Zhao
    • , Purba Mukherjee
    • , Bhuvan Molparia
    • , Nina E. Moore
    • , German R. Aleman Muench
    • , Jiejun Wu
    • , Weixuan Chen
    • , Antonio F. M. Pinto
    • , Bruce E. Maryanoff
    • , Alan Saghatelian
    • , Pejman Soroosh
    • , Ali Torkamani
    • , Luke J. Leman
    •  & M. Reza Ghadiri
  • Brief Communication |

    Mass spectral fragmentations of lipids across 117 lipid subclasses are presented in a lipidome atlas.

    • Hiroshi Tsugawa
    • , Kazutaka Ikeda
    • , Mikiko Takahashi
    • , Aya Satoh
    • , Yoshifumi Mori
    • , Haruki Uchino
    • , Nobuyuki Okahashi
    • , Yutaka Yamada
    • , Ipputa Tada
    • , Paolo Bonini
    • , Yasuhiro Higashi
    • , Yozo Okazaki
    • , Zhiwei Zhou
    • , Zheng-Jiang Zhu
    • , Jeremy Koelmel
    • , Tomas Cajka
    • , Oliver Fiehn
    • , Kazuki Saito
    • , Masanori Arita
    •  & Makoto Arita
  • Article |

    The genome-wide activity of Cas9 is measured in unprecedented detail.

    • Cicera R. Lazzarotto
    • , Nikolay L. Malinin
    • , Yichao Li
    • , Ruochi Zhang
    • , Yang Yang
    • , GaHyun Lee
    • , Eleanor Cowley
    • , Yanghua He
    • , Xin Lan
    • , Kasey Jividen
    • , Varun Katta
    • , Natalia G. Kolmakova
    • , Christopher T. Petersen
    • , Qian Qi
    • , Evgheni Strelcov
    • , Samantha Maragh
    • , Giedre Krenciute
    • , Jian Ma
    • , Yong Cheng
    •  & Shengdar Q. Tsai
  • Author Correction |

    • Tatiana Mitiouchkina
    • , Alexander S. Mishin
    • , Louisa Gonzalez Somermeyer
    • , Nadezhda M. Markina
    • , Tatiana V. Chepurnyh
    • , Elena B. Guglya
    • , Tatiana A. Karataeva
    • , Kseniia A. Palkina
    • , Ekaterina S. Shakhova
    • , Liliia I. Fakhranurova
    • , Sofia V. Chekova
    • , Aleksandra S. Tsarkova
    • , Yaroslav V. Golubev
    • , Vadim V. Negrebetsky
    • , Sergey A. Dolgushin
    • , Pavel V. Shalaev
    • , Dmitry Shlykov
    • , Olesya A. Melnik
    • , Victoria O. Shipunova
    • , Sergey M. Deyev
    • , Andrey I. Bubyrev
    • , Alexander S. Pushin
    • , Vladimir V. Choob
    • , Sergey V. Dolgov
    • , Fyodor A. Kondrashov
    • , Ilia V. Yampolsky
    •  & Karen S. Sarkisyan
  • Brief Communication |

    Base editors that modify both adenosine and cytosine broaden the potential applications of base editing.

    • Rina C. Sakata
    • , Soh Ishiguro
    • , Hideto Mori
    • , Mamoru Tanaka
    • , Kenji Tatsuno
    • , Hiroki Ueda
    • , Shogo Yamamoto
    • , Motoaki Seki
    • , Nanami Masuyama
    • , Keiji Nishida
    • , Hiroshi Nishimasu
    • , Kazuharu Arakawa
    • , Akihiko Kondo
    • , Osamu Nureki
    • , Masaru Tomita
    • , Hiroyuki Aburatani
    •  & Nozomu Yachie
  • Brief Communication |

    Base editors that modify both adenine and cytosine broaden the potential applications of base editing.

    • Xiaohui Zhang
    • , Biyun Zhu
    • , Liang Chen
    • , Ling Xie
    • , Weishi Yu
    • , Ying Wang
    • , Linxi Li
    • , Shuming Yin
    • , Lei Yang
    • , Handan Hu
    • , Honghui Han
    • , Yongmei Li
    • , Liren Wang
    • , Geng Chen
    • , Xueyun Ma
    • , Hongquan Geng
    • , Wanfeng Huang
    • , Xiufeng Pang
    • , Zuozhen Yang
    • , Yuxuan Wu
    • , Stefan Siwko
    • , Ryo Kurita
    • , Yukio Nakamura
    • , Li Yang
    • , Mingyao Liu
    •  & Dali Li
  • Publisher Correction |

    • Joo Guan Yeo
    • , Martin Wasser
    • , Pavanish Kumar
    • , Lu Pan
    • , Su Li Poh
    • , Fauziah Ally
    • , Thaschawee Arkachaisri
    • , Amanda Jin Mei Lim
    • , Jing Yao Leong
    • , Liyun Lai
    • , Kee Thai Yeo
    • , Elene Seck Choon Lee
    • , Camillus Jian Hui Chua
    • , Anis Larbi
    • , Ma Shwe Zin Nyunt
    • , Tze Pin Ng
    • , Sabrina Chiesa
    • , Marco Gattorno
    • , Alberto Martini
    • , Bhairav Suryakant Paleja
    • , Charles-Antoine Dutertre
    • , Jinmiao Chen
    • , Katherine Nay Yaung
    • , Swee Ping Tang
    • , Sue Kheng Ng
    • , Chee Fu Yung
    • , Angela Yun June Tan
    • , Shu Ying Lee
    • , Florent Ginhoux
    •  & Salvatore Albani