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A joint focus with Nature Reviews Drug Discovery on RNA-based therapeutics presents a series of articles detailing recent progress in chemistries and delivery technologies that have propelled the clinical advancement of oligonucleotide therapies as well as highlighting commercial advances in RNA vaccines.
Single cell technologies are becoming increasingly important tools in biological analysis. Complementing average measurements on bulk populations of cells, single-cell measurements provide a finer-grained picture of complex biology and unmask heterogeneity that is present in tissues.
Advances in technology across all areas of science have ushered in an era of big data, providing researchers with unprecedented opportunities to understand how biological systems function and interact. Scientists are now faced with the challenge of developing sophisticated computational tools capable of unravelling these data and uncovering important biological signals. Computational biology will continue to play a key role in facilitating multi-disciplinary collaborations, encouraging data sharing and establishing experimental and analytical standards in the life sciences.
This Web Collection presents the results of the RNA Sequencing Quality Control (SEQC) project that sought to evaluate the reproducibility and comparability of high-throughput sequencing of RNA (RNA-seq). Data from several different laboratories are compared and the performance of different sequencing platforms and data analysis approaches are assessed, together with benchmarking against DNA microarrays. Ultimately, these multi-platform, cross-site studies will enable RNA-seq to be applied more broadly in analyzing large cohorts for discovery research and clinical use. This is the latest phase of a collaboration between government, academic and industry researchers as part of the MicroArray Quality Control (MAQC) consortium.We are grateful for the support of our sponsors, the FDA's National Center for Toxicological Research (NCTR/FDA) and the State Key Laboratory of Genetic Engineering (SKLGE) at Fudan University. As always, Nature Research carries sole responsibility for all editorial content.
Translating the power of high-throughput sequencing technologies from the research sphere into the clinic is a current major focus for many health-care providers and researchers, and the power of these technologies is being harnessed to address an increasingly diverse range of problems. Excitingly, real benefits for patients are starting to emerge in areas from infectious disease and cancer, to common and rare genetic disorders and pre-natal testing. At this critical turning point, this collection highlights the breadth of applications of next-generation sequencing technologies in the clinic and the importance of the insights that are being gained through these methods to improve health.
Research in regenerative medicine is advancing toward the goal of repairing damaged tissue and organs. Nature Medicine and Nature Biotechnology present a collection of reviews, features and commentaries that explore our current mechanistic understanding of stem cells, and the emerging technologies that will bring regenerative medicine to the clinic.
New technologies enable analysis of the extraordinarily diverse and polymorphic components of the immune system–especially the human immune system–at a level of unprecedented detail. Reviews and a Commentary specially commissioned by Nature Biotechnology and Nature Immunology discuss these new methodologies, and how they may be applied to track immune status in health and disease, as well as to reveal new basic immunological insight. A Correspondence describing an initiative to design tools and resources to facilitate these high-dimensional analyses is also included.
This focus presents the results of the RNA Sequencing Quality Control (SEQC) project of the MicroArray Quality Control (MAQC) Consortium that sought to evaluate the comparability of RNA-seq data from many different laboratories and of assessing different sequencing platforms and data analysis approaches and their performance compared with DNA microarrays. Ultimately, these multi-platform, cross-site studies will enable RNA-seq to be applied more broadly in analyzing large cohorts for discovery research and clinical use.
The 2014 Nobel Prize in Chemistry was awarded for the development of superresolution fluorescence microscopy, which enables the imaging of fine biological structures previously thought to be unresolvable using light. This collection of news pieces and articles by the Nobel laureates and their collaborators celebrates this achievement.
Researchers have generated more than 3.5 terabytes of human microbiome genomic information – more than 1,000 times that generated by the Human Genome Project. This Focus highlights progress in microbiome research and how these data might translate into a better understanding of human diseases and rational design of new therapies.
Performance gains and falling costs have fueled diverse applications of high-throughput DNA sequencing. This focus issue of Nature Biotechnology summarizes the current status of these technologies as applied to life sciences and medical research. Produced with support from Ion Torrent - by Life Technologies.