Correspondence |
Articles in 2021
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- 2021 (25)
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Article |
inStrain profiles population microdiversity from metagenomic data and sensitively detects shared microbial strains
A metagenome analysis tool identifies microbial strains within and between populations.
- Matthew R. Olm
- , Alexander Crits-Christoph
- , Keith Bouma-Gregson
- , Brian A. Firek
- , Michael J. Morowitz
- & Jillian F. Banfield
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Article |
Assessing single-cell transcriptomic variability through density-preserving data visualization
den-SNE and densMAP enhance single-cell transcriptomic data visualization by incorporating density information.
- Ashwin Narayan
- , Bonnie Berger
- & Hyunghoon Cho
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Article |
Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes
Clonal subpopulations in human tumors are identified from single-cell RNA-seq data.
- Ruli Gao
- , Shanshan Bai
- , Ying C. Henderson
- , Yiyun Lin
- , Aislyn Schalck
- , Yun Yan
- , Tapsi Kumar
- , Min Hu
- , Emi Sei
- , Alexander Davis
- , Fang Wang
- , Simona F. Shaitelman
- , Jennifer Rui Wang
- , Ken Chen
- , Stacy Moulder
- , Stephen Y. Lai
- & Nicholas E. Navin
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News in Brief |
Around the world in a month
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News in Brief |
FDA clears first drug for premature aging disease
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News in Brief |
Antibody–drug conjugates for cancer score with ROR1
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Patents |
Circular RNA
Recent patents regarding the preparation, amplification and therapeutic use of circular RNA.
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News in Brief |
Thumbs up for cholesterol-slashing siRNA blockbuster
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News in Brief |
AstraZeneca joins Russia to boost coronavirus vaccine
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News |
Hunt for improved monoclonals against coronavirus gathers pace
Following mixed results in the clinic against COVID-19, antibody engineers are further optimizing SARS-CoV-2 antibodies with the aim of improving outcomes.
- Ken Garber
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News |
First small-molecule drug targeting RNA gains momentum
The new drug not only is a boon for patients with spinal muscular atrophy, but also may spearhead the development of further chemical RNA modulators for a broad range of conditions.
- Cormac Sheridan
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News |
BTK blockers make headway in multiple sclerosis
By targeting both arms of the immune system, not just B cells, brain-penetrant inhibitors of Bruton’s tyrosine kinase could improve on anti-CD20 therapy for patients with multiple sclerosis.
- Elie Dolgin
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Career Feature |
Immersive virtual reality as a competitive training strategy for the biopharma industry
Immersive virtual reality simulations tailored to aspiring industry operators in biopharma manufacturing could become a cost-effective alternative to real-life training for teaching practical skills.
- Philip Wismer
- , Ainara Lopez Cordoba
- , Sarune Baceviciute
- , Frederik Clauson-Kaas
- & Morten Otto Alexander Sommer
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Patents |
An administrative fix for manufacturing process patent thickets
Biosimilar manufacturing process patent applications first filed more than a year after the biologic is approved, which represent the largest source of patent assertions in biosimilar litigation, could be addressed without requiring intervention by either the courts or Congress.
- Arti K. Rai
- & W. Nicholson Price II
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Article |
Volumetric live cell imaging with three-dimensional parallelized RESOLFT microscopy
A super-resolution microscope images live cells in 3D with high speed, large fields of view and minimal photodamage.
- Andreas Bodén
- , Francesca Pennacchietti
- , Giovanna Coceano
- , Martina Damenti
- , Michael Ratz
- & Ilaria Testa
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Article |
Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice
CRISPR–Cas9 eliminates herpes simplex virus both in the corneal infection site and in the viral reservoir of the trigeminal ganglia.
- Di Yin
- , Sikai Ling
- , Dawei Wang
- , Yao Dai
- , Hao Jiang
- , Xujiao Zhou
- , Soren R. Paludan
- , Jiaxu Hong
- & Yujia Cai
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Article |
ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin
Circulating cell-free DNA from patients is analyzed by ChIP-seq to reconstruct gene expression in human organs and tumors.
- Ronen Sadeh
- , Israa Sharkia
- , Gavriel Fialkoff
- , Ayelet Rahat
- , Jenia Gutin
- , Alon Chappleboim
- , Mor Nitzan
- , Ilana Fox-Fisher
- , Daniel Neiman
- , Guy Meler
- , Zahala Kamari
- , Dayana Yaish
- , Tamar Peretz
- , Ayala Hubert
- , Jonathan E. Cohen
- , Azzam Salah
- , Mark Temper
- , Albert Grinshpun
- , Myriam Maoz
- , Samir Abu-Gazala
- , Ami Ben Ya’acov
- , Eyal Shteyer
- , Rifaat Safadi
- , Tommy Kaplan
- , Ruth Shemer
- , David Planer
- , Eithan Galun
- , Benjamin Glaser
- , Aviad Zick
- , Yuval Dor
- & Nir Friedman
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Podcast |
First Rounders: Grace Colón
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Brief Communication |
Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus
Left-handed DNA probes improve super-resolution DNA-PAINT imaging in the nucleus by reducing background.
- H. J. Geertsema
- , G. Aimola
- , V. Fabricius
- , J. P. Fuerste
- , B. B. Kaufer
- & H. Ewers
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Letter |
Improved metagenome binning and assembly using deep variational autoencoders
Metagenomics data are resolved into their constituent genomes using a new deep learning method.
- Jakob Nybo Nissen
- , Joachim Johansen
- , Rosa Lundbye Allesøe
- , Casper Kaae Sønderby
- , Jose Juan Almagro Armenteros
- , Christopher Heje Grønbech
- , Lars Juhl Jensen
- , Henrik Bjørn Nielsen
- , Thomas Nordahl Petersen
- , Ole Winther
- & Simon Rasmussen
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Letter |
A five-transgene cassette confers broad-spectrum resistance to a fungal rust pathogen in wheat
Combining fungal-resistance genes into a single cassette enables the generation of highly resistant wheat lines.
- Ming Luo
- , Liqiong Xie
- , Soma Chakraborty
- , Aihua Wang
- , Oadi Matny
- , Michelle Jugovich
- , James A. Kolmer
- , Terese Richardson
- , Dhara Bhatt
- , Mohammad Hoque
- , Mehran Patpour
- , Chris Sørensen
- , Diana Ortiz
- , Peter Dodds
- , Burkhard Steuernagel
- , Brande B. H. Wulff
- , Narayana M. Upadhyaya
- , Rohit Mago
- , Sambasivam Periyannan
- , Evans Lagudah
- , Roger Freedman
- , T. Lynne Reuber
- , Brian J. Steffenson
- & Michael Ayliffe
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Resource |
Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries
An improved workflow enables a 42-fold higher throughput of activity-based protein profiling.
- Miljan Kuljanin
- , Dylan C. Mitchell
- , Devin K. Schweppe
- , Ajami S. Gikandi
- , David P. Nusinow
- , Nathan J. Bulloch
- , Ekaterina V. Vinogradova
- , David L. Wilson
- , Eric T. Kool
- , Joseph D. Mancias
- , Benjamin F. Cravatt
- & Steven P. Gygi