News & Views

Two major advances in optical pooled screening improve substantially on sensitivity and robustness, expanding its applicability to a broader range of biological contexts.

Escherichia coli engineered to display cytokines destroy hard-to-treat tumors by boosting the activity of local native and adoptive immune effector cells.

Redesigning mRNA with chemo-topological strategies improves its stability and translation efficiency, paving the way for more effective mRNA therapeutics.

A differentiation method informed by developmental biology converts human pluripotent stem cells to engraftable hematopoietic stem and progenitor cells without the use of transgenes.

A method using retron recombineering for phage genome modification may facilitate access to therapeutic phages.

Two CRISPR tools harness DNA-dependent polymerases for genome editing — and may overcome some limitations of prime editors.

A mini-colon device mimics colorectal tumors and their interactions with neighboring healthy tissue, stromal cells and immune cells.

Research on enzymatic RNA synthesis has long been eclipsed by work on DNA—but a new method provides a leap forward for RNA.

A therapeutic strategy harnesses evolutionary dynamics to overcome tumor resistance to targeted therapies.

Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks.

A differentiation protocol to produce off-the-shelf natural killer T cells may enable clinical application.

A strategy for creating drugs that can be quickly neutralized is demonstrated for anticoagulants.

An engineered retrotransposon achieves targeted gene transfer into the human genome.

A new mass analyzer enables protein identification at high speed and depth.

Prime editing in vivo is systematically improved with an eye to clinical translation.

A synthetic auxin improves the growth of adventitious roots in various plant species.

A basket-like device records the electrical activity of neural organoids over months of maturation.

An integrated wearable and wireless ultrasound device enables the continuous monitoring of physiological information from tissues in moving individuals.

Prime- and base-editor mouse models enable finely tuned, efficient functional studies of cancer-associated genetic changes.

A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.