News & Views

Bioinformatic mining and engineering of serine recombinases yields improved genome editing tools.

Super-resolution microscopy at ångström precision could pave the way to optical structural biology in cells.

New methods for mapping the mRNA modifications N⁶-methyladenosine and pseudouridine enable large-scale functional analyses.

Protein structure prediction with a language model improves accuracy for orphan and designed proteins.

Logic-gated monoclonal antibodies have been designed to improve safety and efficacy.

An influenza vaccine is created by attenuating the live virus through targeted proteolysis.

Reprogramming of antibody responses in mice is achieved via adeno-associated virus delivery of SaCas9, single guide RNA (sgRNA) and a repair template targeting immunoglobulin genes.

CRISPR base- and prime-editing pooled screens reveal the function of genetic variants at unprecedented resolution.

Artificial intelligence finds candidate peptide antibiotics in the human gut microbiome.

A new assay for cell-free DNA fragmentation improves prediction of gene expression in liquid biopsies.

A thorough study of lab-made pancreatic beta cells reveals their differences from primary cells.

Producing commodity chemicals in bacteria that live on industrial air pollution captures more greenhouse gases than it emits.

A deep learning algorithm for protein structure prediction is used in reverse for de novo protein design.

Tagging peptides with DNA allows repeated reads via a helicase in a nanopore with reduced error rates.

An algorithm that uses evolutionary data to predict disease variants makes a case for embracing computational evidence for clinical interpretation of genetic variation.

Genome-editing tools are optimized by identifying genes that affect DNA repair.

RNA cargo is transferred into cultured cells using a fully human delivery system.

An improved light-sheet microscope images live cells at sub-100-nm axial resolution.

Embryo models built from stem cells promise to shed light on human development.

Targeting a gene linked to cardiovascular disease shows therapeutic promise.