Browse Articles

An expert in network dynamics and cell interactions describes her interdisciplinary background, creativity and building community in her lab during a pandemic.

The COVID-19 pandemic brought mRNA vaccines to market in a short period, pointing the entire drug development field in the direction of mRNA treatment.

The Open Institute of the African BioGenome Project empowers African scientists and institutions with the skill sets, capacity and infrastructure to advance scientific knowledge and innovation and drive economic growth.

BugSigDB is a community-editable wiki that harmonizes how key microbial differential abundance methods and results are reported, identifying rare and common patterns across the literature of published host-associated microbiome studies.

A database of microbial signatures is used for systematic comparison of differential abundance patterns.

Engineered cancer mutations are linked with phenotypes in a multiplexed single-cell technology.

Data integration between weakly linked single-cell modalities is challenging using existing methods. Therefore, we developed MaxFuse to enable matching and integration between cells from modalities such as single-cell spatial proteomic datasets and single-cell transcriptomic datasets, or other modalities where features are only weakly correlated.

Although base and prime editors can be highly efficient in human hematopoietic stem cells, we find they can cause adverse cellular responses, including reduced engraftment and the generation of DNA double-strand breaks and genotoxic byproducts, albeit at a lower frequency than Cas9. We also find that base editors increase the genome-wide mutagenic load.

A new RNA reference set improves detection of differential expression in clinical settings.

Protein sequence and structural similarities in large databases are rapidly identified using machine learning.

Base and prime editors induce double-strand breaks, deletions and translocations in hematopoietic cells.

Multi-omics data are readily integrated using quartet reference materials.

MaxFuse enables data integration between modalities even when features are weakly correlated.

Stabilizing the unstable may be the road to therapeutics for unmet needs.

Metabolites and RNA in a tissue section are profiled simultaneously.

Mapping fixed brain samples with extracellular labeling and optical microscopy reveals synaptic connections.

Human glial progenitors transplanted into a chimeric mouse brain replace sick or older human glia, a finding that could one day lead to new treatments for neurological disease.

A TALE-based modular base editing system shows high strand specificity in multiple organelles.

Simultaneous single-cell profiling of 5hmC and 5mC shows their unique regulatory roles.