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After growing up collecting fossils and reading science books, this group leader’s research now lies at the interface of biology, artificial intelligence and genomics.

Recent moves of note in and around the biotech and pharma industries.

Policy changes are needed to ensure that Cooperative Research and Development Agreements and patent applications filed by the US National Institutes of Health are aligned with the interests of the American public.

ChatGPT holds transformative potential for medicine across clinical, research and educational domains.

Long-term expression of AAV transgenes in macaque liver is traced to integrated vectors.

Quantum dots won the Nobel Prize, but proved to be a miss in the biomedical space.

Armed with gene technologies and CAR-Ts, scientists are attempting to eliminate viruses that escape immune detection and lurk in tissues for years.

Challenges and opportunities for engineering and studying the soil microbiome are discussed.

As new technologies hit the market, synthetic DNA is available faster and cheaper than ever before. Regulators are preparing to step in to limit opportunities for misuse.

Shortages of CAR T cells should be alleviated by distributed manufacturing, according to Elsallab and Maus.

A recently discovered RNA species on the cell surface is studied by proximity ligation.

Biopharma companies debate whether to patent their algorithms for finding medicines.

Using an experimental and computational framework inspired by compressed sensing, we greatly reduced the number of measurements needed to run Perturb-seq. Our compressed Perturb-seq strategy relies on collecting measurements comprising random linear combinations of genetic perturbations, followed by deconvolving the perturbation effects on the transcriptome using sparsity-exploiting algorithms.

Genetic engineering to block immune destruction of transplanted cells succeeds in macaques.

Compressed Perturb-seq incorporates compressed sensing to genetic screening for scalable discovery of genetic interactions.

A large resource of shared tumor neoepitopes aims to accelerate cancer immunotherapy.