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  • Patents |

    Recent patents regarding the preparation, amplification and therapeutic use of circular RNA.

  • People |

    Recent moves of note in and around the biotech and pharma industries.

  • News |

    The new drug not only is a boon for patients with spinal muscular atrophy, but also may spearhead the development of further chemical RNA modulators for a broad range of conditions.

    • Cormac Sheridan

  • News |

    By targeting both arms of the immune system, not just B cells, brain-penetrant inhibitors of Bruton’s tyrosine kinase could improve on anti-CD20 therapy for patients with multiple sclerosis.

    • Elie Dolgin

  • Patents |

    Biosimilar manufacturing process patent applications first filed more than a year after the biologic is approved, which represent the largest source of patent assertions in biosimilar litigation, could be addressed without requiring intervention by either the courts or Congress.

    • Arti K. Rai
    •  & W. Nicholson Price II

  • Article |

    Circulating cell-free DNA from patients is analyzed by ChIP-seq to reconstruct gene expression in human organs and tumors.

    • Ronen Sadeh
    • , Israa Sharkia
    • , Gavriel Fialkoff
    • , Ayelet Rahat
    • , Jenia Gutin
    • , Alon Chappleboim
    • , Mor Nitzan
    • , Ilana Fox-Fisher
    • , Daniel Neiman
    • , Guy Meler
    • , Zahala Kamari
    • , Dayana Yaish
    • , Tamar Peretz
    • , Ayala Hubert
    • , Jonathan E. Cohen
    • , Azzam Salah
    • , Mark Temper
    • , Albert Grinshpun
    • , Myriam Maoz
    • , Samir Abu-Gazala
    • , Ami Ben Ya’acov
    • , Eyal Shteyer
    • , Rifaat Safadi
    • , Tommy Kaplan
    • , Ruth Shemer
    • , David Planer
    • , Eithan Galun
    • , Benjamin Glaser
    • , Aviad Zick
    • , Yuval Dor
    •  & Nir Friedman

  • Letter |

    Metagenomics data are resolved into their constituent genomes using a new deep learning method.

    • Jakob Nybo Nissen
    • , Joachim Johansen
    • , Rosa Lundbye Allesøe
    • , Casper Kaae Sønderby
    • , Jose Juan Almagro Armenteros
    • , Christopher Heje Grønbech
    • , Lars Juhl Jensen
    • , Henrik Bjørn Nielsen
    • , Thomas Nordahl Petersen
    • , Ole Winther
    •  & Simon Rasmussen

  • Letter |

    Combining fungal-resistance genes into a single cassette enables the generation of highly resistant wheat lines.

    • Ming Luo
    • , Liqiong Xie
    • , Soma Chakraborty
    • , Aihua Wang
    • , Oadi Matny
    • , Michelle Jugovich
    • , James A. Kolmer
    • , Terese Richardson
    • , Dhara Bhatt
    • , Mohammad Hoque
    • , Mehran Patpour
    • , Chris Sørensen
    • , Diana Ortiz
    • , Peter Dodds
    • , Burkhard Steuernagel
    • , Brande B. H. Wulff
    • , Narayana M. Upadhyaya
    • , Rohit Mago
    • , Sambasivam Periyannan
    • , Evans Lagudah
    • , Roger Freedman
    • , T. Lynne Reuber
    • , Brian J. Steffenson
    •  & Michael Ayliffe

  • Correspondence
    | Open Access

    • Christoph Bock
    • , Michael Boutros
    • , J. Gray Camp
    • , Laura Clarke
    • , Hans Clevers
    • , Juergen A. Knoblich
    • , Prisca Liberali
    • , Aviv Regev
    • , Anne C. Rios
    • , Oliver Stegle
    • , Hendrik G. Stunnenberg
    • , Sarah A. Teichmann
    • , Barbara Treutlein
    •  & Robert G. J. Vries

  • Editorial |

    Emergency Use Authorizations for two mRNA COVID-19 vaccines represent a turning point in the pandemic. They also herald a new era for vaccinology.

  • Article |

    Single-cell analysis reveals how anti-hypertensive drugs affect the risk of severe disease in patients with COVID-19 who have hypertension.

    • Saskia Trump
    • , Soeren Lukassen
    • , Markus S. Anker
    • , Robert Lorenz Chua
    • , Johannes Liebig
    • , Loreen Thürmann
    • , Victor Max Corman
    • , Marco Binder
    • , Jennifer Loske
    • , Christina Klasa
    • , Teresa Krieger
    • , Bianca P. Hennig
    • , Marey Messingschlager
    • , Fabian Pott
    • , Julia Kazmierski
    • , Sven Twardziok
    • , Jan Philipp Albrecht
    • , Jürgen Eils
    • , Sara Hadzibegovic
    • , Alessia Lena
    • , Bettina Heidecker
    • , Thore Bürgel
    • , Jakob Steinfeldt
    • , Christine Goffinet
    • , Florian Kurth
    • , Martin Witzenrath
    • , Maria Theresa Völker
    • , Sarah Dorothea Müller
    • , Uwe Gerd Liebert
    • , Naveed Ishaque
    • , Lars Kaderali
    • , Leif-Erik Sander
    • , Christian Drosten
    • , Sven Laudi
    • , Roland Eils
    • , Christian Conrad
    • , Ulf Landmesser
    •  & Irina Lehmann

  • Article |

    A comprehensive comparison of 20 single-cell RNA-seq datasets derived from the two cell lines analyzed using six preprocessing pipelines, eight normalization methods and seven batch-correction algorithms derived from four different sequencing platforms at different centers.

    • Wanqiu Chen
    • , Yongmei Zhao
    • , Xin Chen
    • , Zhaowei Yang
    • , Xiaojiang Xu
    • , Yingtao Bi
    • , Vicky Chen
    • , Jing Li
    • , Hannah Choi
    • , Ben Ernest
    • , Bao Tran
    • , Monika Mehta
    • , Parimal Kumar
    • , Andrew Farmer
    • , Alain Mir
    • , Urvashi Ann Mehra
    • , Jian-Liang Li
    • , Malcolm Moos Jr.
    • , Wenming Xiao
    •  & Charles Wang

  • Author Correction |

    • Ron Cohen
    • , Cedric Francois
    • , John Crowley
    • , Paul Hastings
    • , Rachel King
    • , Ted W. Love
    • , John Maraganore
    • , Michelle McMurry-Heath
    • , Jeremy Levin
    • , Chris Adams
    • , Sunny Al-Shamma
    • , Bonnie Anderson
    • , Christopher R. Anzalone
    • , Mara G. Aspinall
    • , James E. Audia
    • , Martin Babler
    • , Jeffrey Bacha
    • , Michael P. Bailey
    • , Christiana Bardon
    • , Mark Barrett
    • , Peter Barrett
    • , Jacob Becraft
    • , Jeffrey Bird
    • , Kevin Bitterman
    • , Robert Blum
    • , Paul Bolno
    • , Michael Bonney
    • , Bruce Booth
    • , Katrine S. Bosley
    • , Sarah Boyce
    • , Marina Bozilenko
    • , Jim Burns
    • , Brook Byers
    • , John Cashman
    • , Devon Cayer
    • , Brian Chee
    • , Chip Clark
    • , Jeffrey Cleland
    • , Ivan Coulter
    • , Gerald F. Cox
    • , Alan Crane
    • , Brian Culley
    • , Karim Dabbagh
    • , Bassil Dahiyat
    • , Daniel A. de Boer
    • , Tony De Fougerolles
    • , Steven R. Deitcher
    • , Sara Jane Demy
    • , Douglas Doerfler
    • , Eric Dube
    • , David J. Earp
    • , Hartmut Ehrlich
    • , Steve Elms
    • , Stephen H. Embury
    • , David R. Epstein
    • , Neil Exter
    • , Alan Ezekowitz
    • , Douglas Fambrough
    • , Stephen J. Farr
    • , Oliver Fetzer
    • , Alexandria Forbes
    • , J. F. Formela
    • , Gordon Foukes
    • , Jackie Fouse
    • , John Fowler
    • , Frederick Frank
    • , Ilan Ganot
    • , Jason Gardner
    • , Christopher Gibson
    • , Gregory Gorgas
    • , Kurt Graves
    • , David Grayzel
    • , Barry Greene
    • , Yvonne Greenstreet
    • , Sheila Gujrathi
    • , Mary Haak-Frendscho
    • , John Hagan
    • , David Hallal
    • , Tom Hallam
    • , Laurie Halloran
    • , William Haseltine
    • , Faheem Hasnain
    • , Peter B. Heifetz
    • , Terry Hermiston
    • , Jeffrey Herz
    • , Richard Heyman
    • , Erik Holmlin
    • , Marcus Hompesch
    • , Wende Hutton
    • , Douglas S. Ingram
    • , John H. Johnson
    • , Perry Karsen
    • , Douglas Kawahata
    • , Edward M. Kaye
    • , Nina Kjellson
    • , Paul Ko Ferrigno
    • , Mike Krenn
    • , Steven Kriegsman
    • , Neil Kumar
    • , John LaMattina
    • , Robert Langer
    • , David Larwood
    • , Matthew Lawrence
    • , Jeff Leerink
    • , Pablo Legoretta
    • , Jeff Leiden
    • , Nick Leschly
    • , Mark Levin
    • , Christopher Linthwaite
    • , Roger Longman
    • , Albert Luderer
    • , Sandy Macrae
    • , Tahir Mahmood
    • , Richard Markus
    • , Tyler Martin
    • , Sean McCarthy
    • , Lee McCracken
    • , Terry McGuire
    • , Gail Mederis
    • , James Mackay
    • , Jerry McMahon
    • , Jill C. Milne
    • , Mauro Miloni
    • , Kenneth I. Moch
    • , Paul Mola
    • , Brett Monia
    • , Walter Moos
    • , Scott W. Morrison
    • , Amit Munshi
    • , Mark Murcko
    • , Amir Nashat
    • , William J. Newell
    • , Steven Nichtberger
    • , Frederic Ors
    • , Stelios Papadopoulos
    • , H. Stewart Parker
    • , Elliot Parks
    • , Kush M. Parmar
    • , Joseph Payne
    • , Mark Perry
    • , Cary G. Pfeffer
    • , William J. Polvino
    • , Mark Pruzanski
    • , Dennis J. Purcell
    • , David E. I. Pyott
    • , Michael G. Raab
    • , Jigar Raythatha
    • , R. Bruce Register
    • , Ronald Renaud Jr
    • , Hollings Renton
    • , Christopher Rhodes
    • , Jason Rhodes
    • , Michael Richman
    • , Howard Robin
    • , Wendye Robbins
    • , William J. Rutter
    • , James Sapirstein
    • , Vicki Sato
    • , Glenn Sblendorio
    • , George Scangos
    • , John A. Scarlett
    • , Drew Schiff
    • , Hans Schikan
    • , James Scibetta
    • , Amy Schulman
    • , Tim Scott
    • , Paul Sekhri
    • , Alpna Seth
    • , Stephen A. Sherwin
    • , Jay M. Short
    • , Mark Simon
    • , Nancy Simonian
    • , Vikas Sinha
    • , Tero Sivola
    • , Moncef Slaoui
    • , Julie Anne Smith
    • , Erika R. Smith
    • , Jean-Pierre Sommadossi
    • , Paula Soteropoulos
    • , Laura Souceck
    • , Travis Stiles
    • , Clifford J. Stocks
    • , David Stover
    • , Arthur Suckow
    • , Mary T. Szela
    • , Robert Tepper
    • , Eric Topol
    • , Andre Turenne
    • , Mark Velleca
    • , Rajeev Venkayya
    • , Dawn Verdugo
    • , Alan Walts
    • , Bing Wang
    • , Neil Warma
    • , Scott Wasserman
    • , Robert Ward
    • , David Webb
    • , Claire Weston
    • , Christoph Westphal
    • , James M. Wilson
    • , Mark S. Wilson
    • , Rick Winningham
    • , Angie You
    • , Bradford Zakes
    • , Elias A. Zerhouni
    • , Daphne Zohar
    •  & Sandy Zweifach

  • Letter
    | Open Access

    Assembly of phased human genomes is achieved by combining long reads and long-range conformational data.

    • Shilpa Garg
    • , Arkarachai Fungtammasan
    • , Andrew Carroll
    • , Mike Chou
    • , Anthony Schmitt
    • , Xiang Zhou
    • , Stephen Mac
    • , Paul Peluso
    • , Emily Hatas
    • , Jay Ghurye
    • , Jared Maguire
    • , Medhat Mahmoud
    • , Haoyu Cheng
    • , David Heller
    • , Justin M. Zook
    • , Tobias Moemke
    • , Tobias Marschall
    • , Fritz J. Sedlazeck
    • , John Aach
    • , Chen-Shan Chin
    • , George M. Church
    •  & Heng Li

  • Letter
    | Open Access

    Assembly of haplotype-resolved human genomes is achieved by combining short and long reads.

    • David Porubsky
    • , Peter Ebert
    • , Peter A. Audano
    • , Mitchell R. Vollger
    • , William T. Harvey
    • , Pierre Marijon
    • , Jana Ebler
    • , Katherine M. Munson
    • , Melanie Sorensen
    • , Arvis Sulovari
    • , Marina Haukness
    • , Maryam Ghareghani
    • , Peter M. Lansdorp
    • , Benedict Paten
    • , Scott E. Devine
    • , Ashley D. Sanders
    • , Charles Lee
    • , Mark J. P. Chaisson
    • , Jan O. Korbel
    • , Evan E. Eichler
    •  & Tobias Marschall

  • Patents |

    Recent patents for methods of making and using chimeric antigen receptor (CAR) T cells to treat cancer and other diseases.

  • News |

    Seres’s success with an industrially made bacterial mix in phase 3 trials against Clostridium difficile infection promises an alternative to fecal microbial transplantation in clinical practice.

    • Mark Ratner

  • People |

    Recent moves of note in and around the biotech and pharma industries.

  • Career Feature |

    Social quarantine has severely impacted the training of new scientists, but the use of virtual platforms can supplement mentorship, making career development seamless.

    • Melanie R. McReynolds
    • , Christina M. Termini
    • , Antentor O. Hinton Jr
    • , Brittany L. Taylor
    • , Zer Vue
    • , Sunny C. Huang
    • , ReAnna S. Roby
    • , Haysetta Shuler
    •  & Calvin S. Carter

  • Editorial |

    Rapid progress is being made in our understanding of RNA–protein interactions, their role in disease and their influence on the action of oligonucleotide drugs.