Browse Articles

  • Patents |

    Recent patents related to systems and methods of imaging.

  • News |

    Epizyme’s EZH2 inhibitor gains two approvals in quick succession — a milestone for this new class of epigenetic cancer drug that targets histone marks with greater precision than previous generations.

    • Ken Garber
  • People |

    Recent moves of note in and around the biotech and pharma industries.

  • Career Feature |

    A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.

    • Michael Francisco
  • Editorial |

    As preliminary research findings are shared more widely and at an increasing pace, action is needed to counter the spread of misinformation.

  • Letter |

    SARS-CoV-2 is reliably detected in nasal swab samples using mass spectrometry and machine learning analysis.

    • Fabiane M. Nachtigall
    • , Alfredo Pereira
    • , Oleksandra S. Trofymchuk
    •  & Leonardo S. Santos
  • News Feature |

    Research groups around the globe are looking to see whether urban wastewater monitoring can be integrated into surveillance systems for SARS-CoV-2 and other pathogens.

    • Charles Schmidt
  • Brief Communication |

    Cell clones in lineage-tracing studies can be isolated for functional experiments.

    • Christian Umkehrer
    • , Felix Holstein
    • , Laura Formenti
    • , Julian Jude
    • , Kimon Froussios
    • , Tobias Neumann
    • , Shona M. Cronin
    • , Lisa Haas
    • , Jesse J. Lipp
    • , Thomas R. Burkard
    • , Michaela Fellner
    • , Thomas Wiesner
    • , Johannes Zuber
    •  & Anna C. Obenauf
  • Article |

    A system to express neoantigens in tumor cells and mice circumvents central T cell tolerance.

    • Martina Damo
    • , Brittany Fitzgerald
    • , Yisi Lu
    • , Mursal Nader
    • , Ivana William
    • , Julie F. Cheung
    • , Kelli A. Connolly
    • , Gena G. Foster
    • , Elliot Akama-Garren
    • , Da-Yae Lee
    • , Greg P. Chang
    • , Vasilena Gocheva
    • , Leah M. Schmidt
    • , Alice Boileve
    • , Josephine H. Wilson
    • , Can Cui
    • , Isabel Monroy
    • , Prashanth Gokare
    • , Peter Cabeceiras
    • , Tyler Jacks
    •  & Nikhil S. Joshi
  • Author Correction |

    • Jacob E. Crawford
    • , David W. Clarke
    • , Victor Criswell
    • , Mark Desnoyer
    • , Devon Cornel
    • , Brittany Deegan
    • , Kyle Gong
    • , Kaycie C. Hopkins
    • , Paul Howell
    • , Justin S. Hyde
    • , Josh Livni
    • , Charlie Behling
    • , Renzo Benza
    • , Willa Chen
    • , Karen L. Dobson
    • , Craig Eldershaw
    • , Daniel Greeley
    • , Yi Han
    • , Bridgette Hughes
    • , Evdoxia Kakani
    • , Joe Karbowski
    • , Angus Kitchell
    • , Erika Lee
    • , Teresa Lin
    • , Jianyi Liu
    • , Martin Lozano
    • , Warren MacDonald
    • , James W. Mains
    • , Matty Metlitz
    • , Sara N. Mitchell
    • , David Moore
    • , Johanna R. Ohm
    • , Kathleen Parkes
    • , Alexandra Porshnikoff
    • , Chris Robuck
    • , Martin Sheridan
    • , Robert Sobecki
    • , Peter Smith
    • , Jessica Stevenson
    • , Jordan Sullivan
    • , Brian Wasson
    • , Allison M. Weakley
    • , Mark Wilhelm
    • , Joshua Won
    • , Ari Yasunaga
    • , William C. Chan
    • , Jodi Holeman
    • , Nigel Snoad
    • , Linus Upson
    • , Tiantian Zha
    • , Stephen L. Dobson
    • , F. Steven Mulligan
    • , Peter Massaro
    •  & Bradley J. White
  • Article |

    A blocking assay based on the recombinant receptor-binding domain of SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 receptor provides an alternative to conventional antibody neutralization assays requiring live virus.

    • Chee Wah Tan
    • , Wan Ni Chia
    • , Xijian Qin
    • , Pei Liu
    • , Mark I.-C. Chen
    • , Charles Tiu
    • , Zhiliang Hu
    • , Vivian Chih-Wei Chen
    • , Barnaby E. Young
    • , Wan Rong Sia
    • , Yee-Joo Tan
    • , Randy Foo
    • , Yongxiang Yi
    • , David C. Lye
    • , Danielle E. Anderson
    •  & Lin-Fa Wang
  • Author Correction |

    • Justin M. Zook
    • , Nancy F. Hansen
    • , Nathan D. Olson
    • , Lesley Chapman
    • , James C. Mullikin
    • , Chunlin Xiao
    • , Stephen Sherry
    • , Sergey Koren
    • , Adam M. Phillippy
    • , Paul C. Boutros
    • , Sayed Mohammad E. Sahraeian
    • , Vincent Huang
    • , Alexandre Rouette
    • , Noah Alexander
    • , Christopher E. Mason
    • , Iman Hajirasouliha
    • , Camir Ricketts
    • , Joyce Lee
    • , Rick Tearle
    • , Ian T. Fiddes
    • , Alvaro Martinez Barrio
    • , Jeremiah Wala
    • , Andrew Carroll
    • , Noushin Ghaffari
    • , Oscar L. Rodriguez
    • , Ali Bashir
    • , Shaun Jackman
    • , John J. Farrell
    • , Aaron M. Wenger
    • , Can Alkan
    • , Arda Soylev
    • , Michael C. Schatz
    • , Shilpa Garg
    • , George Church
    • , Tobias Marschall
    • , Ken Chen
    • , Xian Fan
    • , Adam C. English
    • , Jeffrey A. Rosenfeld
    • , Weichen Zhou
    • , Ryan E. Mills
    • , Jay M. Sage
    • , Jennifer R. Davis
    • , Michael D. Kaiser
    • , John S. Oliver
    • , Anthony P. Catalano
    • , Mark J. P. Chaisson
    • , Noah Spies
    • , Fritz J. Sedlazeck
    •  & Marc Salit
  • Brief Communication |

    The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis.

    • Michael A. Skinnider
    • , Jordan W. Squair
    • , Claudia Kathe
    • , Mark A. Anderson
    • , Matthieu Gautier
    • , Kaya J. E. Matson
    • , Marco Milano
    • , Thomas H. Hutson
    • , Quentin Barraud
    • , Aaron A. Phillips
    • , Leonard J. Foster
    • , Gioele La Manno
    • , Ariel J. Levine
    •  & Grégoire Courtine
  • Resource
    | Open Access

    More than 200,000 gut prokaryotic reference genomes and the proteins they encode are collated, providing comprehensive resources for microbiome researchers.

    • Alexandre Almeida
    • , Stephen Nayfach
    • , Miguel Boland
    • , Francesco Strozzi
    • , Martin Beracochea
    • , Zhou Jason Shi
    • , Katherine S. Pollard
    • , Ekaterina Sakharova
    • , Donovan H. Parks
    • , Philip Hugenholtz
    • , Nicola Segata
    • , Nikos C. Kyrpides
    •  & Robert D. Finn
  • Author Correction |

    • Jim Aitken
    • , Karen Ambrose
    • , Sam Barrell
    • , Rupert Beale
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Richard Byrne
    • , Simon Caidan
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Margaret Crawford
    • , Laura Cubitt
    • , Vicky Dearing
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Efthymios Fidanis
    • , Alessandra Gaiba
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Jacki Goldman
    • , Robert Goldstone
    • , Paul R. Grant
    • , Maria Greco
    • , Judith Heaney
    • , Steve Hindmarsh
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Michael Hubank
    • , Deborah Hughes
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Stuart Kirk
    • , Svend Kjaer
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Wei-Ting Lu
    • , James I. MacRae
    • , John Matthews
    • , Laura E. McCoy
    • , Catherine Moore
    • , David Moore
    • , Eleni Nastouli
    • , Jerome Nicod
    • , Luke Nightingale
    • , Jessica Olsen
    • , Nicola O’Reilly
    • , Amar Pabari
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Nigel Peat
    • , Marc Pollitt
    • , Peter Ratcliffe
    • , Caetano Reis e Sousa
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Chloe Roustan
    • , Andrew Rowan
    • , Gee Yen Shin
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Amy Strange
    • , Charles Swanton
    • , James M. A. Turner
    • , Melanie Turner
    • , Andreas Wack
    • , Philip A. Walker
    • , Sophia Ward
    • , Wai Keong Wong
    • , Joshua Wright
    • , Mary Wu
    • , Jim Aitken
    • , Zoe Allen
    • , Rachel Ambler
    • , Karen Ambrose
    • , Emma Ashton
    • , Alida Avola
    • , Samutheswari Balakrishnan
    • , Caitlin Barns-Jenkins
    • , Genevieve Barr
    • , Sam Barrell
    • , Souradeep Basu
    • , Rupert Beale
    • , Clare Beesley
    • , Nisha Bhardwaj
    • , Shahnaz Bibi
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Michael J. Blackman
    • , Dominique Bonnet
    • , Faye Bowker
    • , Malgorzata Broncel
    • , Claire Brooks
    • , Michael D. Buck
    • , Andrew Buckton
    • , Timothy Budd
    • , Alana Burrell
    • , Louise Busby
    • , Claudio Bussi
    • , Simon Butterworth
    • , Fiona Byrne
    • , Richard Byrne
    • , Simon Caidan
    • , Joanna Campbell
    • , Johnathan Canton
    • , Ana Cardoso
    • , Nick Carter
    • , Luiz Carvalho
    • , Raffaella Carzaniga
    • , Natalie Chandler
    • , Qu Chen
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Bobbi Clayton
    • , Clementina Cobolli Gigli
    • , Zena Collins
    • , Sally Cottrell
    • , Margaret Crawford
    • , Laura Cubitt
    • , Tom Cullup
    • , Heledd Davies
    • , Patrick Davis
    • , Dara Davison
    • , Vicky Dearing
    • , Solene Debaisieux
    • , Monica Diaz-Romero
    • , Alison Dibbs
    • , Jessica Diring
    • , Paul C. Driscoll
    • , Annalisa D’Avola
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Dimitrios Evangelopoulos
    • , Rupert Faraway
    • , Antony Fearns
    • , Aaron Ferron
    • , Efthymios Fidanis
    • , James Fleming
    • , Bruno Frederico
    • , Alessandra Gaiba
    • , Anthony Gait
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Liam Gaul
    • , Helen M. Golding
    • , Jacki Goldman
    • , Robert Goldstone
    • , Belen Gomez Dominguez
    • , Hui Gong
    • , Paul R. Grant
    • , Maria Greco
    • , Mariana Grobler
    • , Anabel Guedan
    • , Maximiliano G. Gutierrez
    • , Fiona Hackett
    • , Ross Hall
    • , Steinar Halldorsson
    • , Suzanne Harris
    • , Sugera Hashim
    • , Lyn Healy
    • , Judith Heaney
    • , Susanne Herbst
    • , Graeme Hewitt
    • , Theresa Higgins
    • , Steve Hindmarsh
    • , Rajnika Hirani
    • , Joshua Hope
    • , Elizabeth Horton
    • , Beth Hoskins
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Louise Howitt
    • , Jacqueline Hoyle
    • , Mint R. Htun
    • , Michael Hubank
    • , Hector Huerga Encabo
    • , Deborah Hughes
    • , Jane Hughes
    • , Almaz Huseynova
    • , Ming-Shih Hwang
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Lucy Jenkins
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Louise Kiely
    • , Anastacio King Spert Teixeira
    • , Stuart Kirk
    • , Svend Kjaer
    • , Ellen Knuepfer
    • , Nikita Komarov
    • , Paul Kotzampaltiris
    • , Konstantinos Kousis
    • , Tammy Krylova
    • , Ania Kucharska
    • , Robyn Labrum
    • , Catherine Lambe
    • , Michelle Lappin
    • , Stacey-Ann Lee
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Hon Wing Liu
    • , Sam Loughlin
    • , Wei-Ting Lu
    • , James I. MacRae
    • , Akshay Madoo
    • , Julie A. Marczak
    • , Mimmi Martensson
    • , Thomas Martinez
    • , Bishara Marzook
    • , John Matthews
    • , Joachim M. Matz
    • , Samuel McCall
    • , Laura E. McCoy
    • , Fiona McKay
    • , Edel C. McNamara
    • , Carlos M. Minutti
    • , Gita Mistry
    • , Miriam Molina-Arcas
    • , Beatriz Montaner
    • , Kylie Montgomery
    • , Catherine Moore
    • , David Moore
    • , Anastasia Moraiti
    • , Lucia Moreira-Teixeira
    • , Joyita Mukherjee
    • , Cristina Naceur-Lombardelli
    • , Eleni Nastouli
    • , Aileen Nelson
    • , Jerome Nicod
    • , Luke Nightingale
    • , Stephanie Nofal
    • , Paul Nurse
    • , Savita Nutan
    • , Caroline Oedekoven
    • , Anne O’Garra
    • , Jean D. O’Leary
    • , Jessica Olsen
    • , Olga O’Neill
    • , Nicola O’Reilly
    • , Paula Ordonez Suarez
    • , Neil Osborne
    • , Amar Pabari
    • , Aleksandra Pajak
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Yogen Patel
    • , Oana Paun
    • , Nigel Peat
    • , Laura Peces-Barba Castano
    • , Ana Perez Caballero
    • , Jimena Perez-Lloret
    • , Magali S. Perrault
    • , Abigail Perrin
    • , Roy Poh
    • , Enzo Z. Poirier
    • , James M. Polke
    • , Marc Pollitt
    • , Lucia Prieto-Godino
    • , Alize Proust
    • , Clinda Puvirajasinghe
    • , Christophe Queval
    • , Vijaya Ramachandran
    • , Abhinay Ramaprasad
    • , Peter Ratcliffe
    • , Laura Reed
    • , Caetano Reis e Sousa
    • , Kayleigh Richardson
    • , Sophie Ridewood
    • , Fiona Roberts
    • , Rowenna Roberts
    • , Angela Rodgers
    • , Pablo Romero Clavijo
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Alice Rossi
    • , Chloe Roustan
    • , Andrew Rowan
    • , Erik Sahai
    • , Aaron Sait
    • , Katarzyna Sala
    • , Theo Sanderson
    • , Pierre Santucci
    • , Fatima Sardar
    • , Adam Sateriale
    • , Jill A. Saunders
    • , Chelsea Sawyer
    • , Anja Schlott
    • , Edina Schweighoffer
    • , Sandra Segura-Bayona
    • , Rajvee Shah Punatar
    • , Joe Shaw
    • , Gee Yen Shin
    • , Mariana Silva Dos Santos
    • , Margaux Silvestre
    • , Matthew Singer
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Louisa Steel
    • , Amy Strange
    • , Adrienne E. Sullivan
    • , Charles Swanton
    • , Michele S. Y. Tan
    • , Zoe H. Tautz-Davis
    • , Effie Taylor
    • , Gunes Taylor
    • , Harriet B. Taylor
    • , Alison Taylor-Beadling
    • , Fernanda Teixeira Subtil
    • , Berta Terré Torras
    • , Patrick Toolan-Kerr
    • , Francesca Torelli
    • , Tea Toteva
    • , Moritz Treeck
    • , Hadija Trojer
    • , Ming-Han C. Tsai
    • , James M. A. Turner
    • , Melanie Turner
    • , Jernej Ule
    • , Rachel Ulferts
    • , Sharon P. Vanloo
    • , Selvaraju Veeriah
    • , Subramanian Venkatesan
    • , Karen Vousden
    • , Andreas Wack
    • , Claire Walder
    • , Philip A. Walker
    • , Yiran Wang
    • , Sophia Ward
    • , Catharina Wenman
    • , Luke Williams
    • , Matthew J. Williams
    • , Wai Keong Wong
    • , Joshua Wright
    • , Mary Wu
    • , Lauren Wynne
    • , Zheng Xiang
    • , Melvyn Yap
    • , Julian A. Zagalak
    • , Davide Zecchin
    •  & Rachel Zillwood
  • Article |

    Improved Cas12a variants and sgRNA design rules enhance genome-wide screens.

    • Peter C. DeWeirdt
    • , Kendall R. Sanson
    • , Annabel K. Sangree
    • , Mudra Hegde
    • , Ruth E. Hanna
    • , Marissa N. Feeley
    • , Audrey L. Griffith
    • , Teng Teng
    • , Samantha M. Borys
    • , Christine Strand
    • , J. Keith Joung
    • , Benjamin P. Kleinstiver
    • , Xuewen Pan
    • , Alan Huang
    •  & John G. Doench
  • Article |

    Off-the-shelf CAR T cells avoid immune rejection in mouse models of allogeneic cancer cell therapy.

    • Feiyan Mo
    • , Norihiro Watanabe
    • , Mary K. McKenna
    • , M. John Hicks
    • , Madhuwanti Srinivasan
    • , Diogo Gomes-Silva
    • , Erden Atilla
    • , Tyler Smith
    • , Pinar Ataca Atilla
    • , Royce Ma
    • , David Quach
    • , Helen E. Heslop
    • , Malcolm K. Brenner
    •  & Maksim Mamonkin