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We have designed a method, binding affinities to native chromatin by sequencing (BANC-seq), to determine the transcription factor concentrations required for binding to regulatory elements across the genome. Our study shows that chromatin context and DNA accessibility are key regulators of transcription factor binding.

From made-to-order genetic therapies to model organisms engineered to be ‘patient avatars’, the technology exists right now to save patients with rare diseases.

Single-cell aggregation with archetypes provides intermediate granularity for downstream analyses.

The impact of chromatin context on transcription factor binding affinities is quantified.

Deep proteome sequencing achieves ~80% coverage of the human proteome.

Limitations of Alphafold2 structure prediction are addressed by including experimentally determined distance constraints.

Modeling contamination sources over multiple samples enhances the analysis of microbiome data.

Recent patents relating to methods, systems and toolkits related to synthetic biology.

Early-stage researchers can greatly benefit from education and skills development in venture creation and commercialization of discoveries.

Recent moves of note in and around the biotech and pharma industries.