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Most plant hormone sensors, including the abscisic acid receptor PYR1, function through chemically induced dimerization. Using computationally designed libraries of PYR1, we created high-affinity receptors for 21 structurally diverse ligands, setting the stage for large-scale small-molecule biosensor development
We developed two quantitative PCR-based assays to detect SARS-CoV-2-specific T cell immunity: qTACT and dqTACT. The assays quantify CXCL10 mRNA, after incubation of whole blood with viral peptides, as a proxy of an antigen-specific T cell response, and will allow population-level monitoring of cellular immunity to SARS-CoV-2.
Even if Amarin prevails in its patent infringement lawsuit, its key patents on Vascepa are likely to be ruled invalid in ongoing litigation, opening the way for generic formulations.
An intensive program supplements student education and collaboration while narrowing the disconnect between rising healthcare needs and trainees with the technical expertise to tackle pandemic-related challenges.
A new study describes a microscope combining three-photon excitation and adaptive optics capable of high-resolution in vivo imaging of fine neuronal structures in the mouse cortex through the intact skull. The authors demonstrate the use of this platform to guide precise laser-mediated microsurgery and for accurate and sensitive functional calcium imaging.
