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Decentralized autonomous organizations are growing as alternative research funding models, but are also strong scientific communities. We should get on board.

Transcription factors containing disordered regions can now be mapped across the genome, aiding functional studies.

Two start-ups are taking a deep dive into cancer genomes to unearth new therapeutic targets.

Food tech companies are taking bacteria that capture CO₂ from air to make edible and nutritious food and drink.

Two veteran protein engineers team up to create a new gene-delivery vehicle.

Killing bacteria in tumors boosts survival in a mouse model of colon cancer.

Lineage tracing using both transcriptomics and chromatin accessibility provides mechanistic insights into cell fate.

mRNA kinetics are described by combining single-cell combinatorial indexing with metabolic labeling and pooled CRISPR screens.

Most features of a cell are determined by gene programs — sets of co-expressed genes that execute a specific function. By incorporating existing knowledge about gene programs and cell types, the Spectra factor analysis method improves how we decode single-cell transcriptomic data and offers insights into challenging tumor immune contexts.

The detection of mobile genetic elements is crucial for exploring the ecology and evolution of microbial communities, and it has diverse implications in biotechnology and public health. geNomad is a computational framework that enables researchers to precisely identifiy and annotate plasmids and viruses in sequencing data on a large scale.

Spectra decomposes gene expression data into interpretable programs using prior knowledge.

A probe reports absolute sodium levels in acidic organelles with single-organelle resolution.

Pfeiffer and Stafforst review and discuss the state-of-the-art tools for precision editing of RNA bases.

geNomad identifies mobile genetic elements in sequencing data.

Functional miRNA targets are identified transcriptome-wide in single cells.

A potassium activity reporter detects organelle-specific channel function.

Combining experimental and computational tools, this company is targeting disordered regions of proteins previously thought to be undruggable.

By using fixed charges to engineer a strong electroosmotic flow, we achieve the unidirectional transport of natural polypeptides across nanopores. Our approach enables native proteins to be transported enzymatically and non-enzymatically in the absence of denaturant and electrophoretic tags, with potential applications for protein sequencing.