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A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.

Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium activity at a single-organelle resolution.

Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashing GLP-1 agonist, with AI-hallucinated proteins a close second. These are followed by drugging options for RNA. The dark horses are virus-free gene therapies and a sweet protein.

β cells derived from stem cells improve blood glucose control in patients with diabetes.

The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this one-time treatment is costly.

Spatial transcriptomics offers a glimpse of how microbiomes interact with their hosts.

Spatial host–microbiome sequencing simultaneously profiles microbes and host transcriptomes from mouse colons.

Interactions among plant hosts, bacteria and fungi are measured at high spatial resolution.

A model of the embryonic human trunk attains a more mature developmental stage than previous models.

Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T cell immunity.

Norepinephrine neurons, a drug target for neurologic diseases, are produced from stem cells.

Neural connectivity in brain tissue is imaged by labeling the extracellular space.

Recent patents relating to the manufacture and design of engineered immunoglobulin polypeptides.