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A method using retron recombineering for phage genome modification may facilitate access to therapeutic phages.

We have learned many lessons from COVID-19, but how to get vaccines to low- and middle-income countries effectively isn’t one of them.

Phage genomes are readily engineered using retron recombineering.

Human hematopoietic cells derived from pluripotent cells repopulate multiple blood lineages in mice.

Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. Atomic AI generates the structure data it needs for its AI model with the aim of RNA drug discovery.

Two CRISPR tools harness DNA-dependent polymerases for genome editing — and may overcome some limitations of prime editors.

The therapeutic principle of allogeneic hematopoietic cell transplantation, one the most common forms of cancer immunotherapy, is alloreactivity, yet its molecular determinants remain largely unknown. An analytical framework now enables personalized assessment of alloreactivity from whole-exome sequencing of donor–recipient pairs, to help with prognostication of disease relapse and immune-mediated complications.

We have discovered an effect, termed stacking-induced intermolecular charge transfer-enhanced Raman scattering (SICTERS), that enhances the Raman signal intensities of small molecules by relying on their self-stacking rather than external substrates. This effect enables the design of substrate-free small-molecule probes for high-resolution, non-invasive transdermal Raman imaging of lymphatic drainage and microvessels.

The sensitivity of in vivo Raman imaging is improved with self-stacked small molecules.

The success of hematopoietic cell transplants is predicted by profiling minor histocompatibility antigens.

Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. A rescued chimeric antigen receptor from Cargo Therapeutics for hard-to-treat lymphomas shows promise in patients while a trispecific advances toward human testing.