Browse Articles

  • Editorial |

    As preliminary research findings are shared more widely and at an increasing pace, action is needed to counter the spread of misinformation.

  • Letter |

    SARS-CoV-2 is reliably detected in nasal swab samples using mass spectrometry and machine learning analysis.

    • Fabiane M. Nachtigall
    • , Alfredo Pereira
    • , Oleksandra S. Trofymchuk
    •  & Leonardo S. Santos
  • News Feature |

    Research groups around the globe are looking to see whether urban wastewater monitoring can be integrated into surveillance systems for SARS-CoV-2 and other pathogens.

    • Charles Schmidt
  • Brief Communication |

    Cell clones in lineage-tracing studies can be isolated for functional experiments.

    • Christian Umkehrer
    • , Felix Holstein
    • , Laura Formenti
    • , Julian Jude
    • , Kimon Froussios
    • , Tobias Neumann
    • , Shona M. Cronin
    • , Lisa Haas
    • , Jesse J. Lipp
    • , Thomas R. Burkard
    • , Michaela Fellner
    • , Thomas Wiesner
    • , Johannes Zuber
    •  & Anna C. Obenauf
  • Article |

    A system to express neoantigens in tumor cells and mice circumvents central T cell tolerance.

    • Martina Damo
    • , Brittany Fitzgerald
    • , Yisi Lu
    • , Mursal Nader
    • , Ivana William
    • , Julie F. Cheung
    • , Kelli A. Connolly
    • , Gena G. Foster
    • , Elliot Akama-Garren
    • , Da-Yae Lee
    • , Greg P. Chang
    • , Vasilena Gocheva
    • , Leah M. Schmidt
    • , Alice Boileve
    • , Josephine H. Wilson
    • , Can Cui
    • , Isabel Monroy
    • , Prashanth Gokare
    • , Peter Cabeceiras
    • , Tyler Jacks
    •  & Nikhil S. Joshi
  • Author Correction |

    • Jacob E. Crawford
    • , David W. Clarke
    • , Victor Criswell
    • , Mark Desnoyer
    • , Devon Cornel
    • , Brittany Deegan
    • , Kyle Gong
    • , Kaycie C. Hopkins
    • , Paul Howell
    • , Justin S. Hyde
    • , Josh Livni
    • , Charlie Behling
    • , Renzo Benza
    • , Willa Chen
    • , Karen L. Dobson
    • , Craig Eldershaw
    • , Daniel Greeley
    • , Yi Han
    • , Bridgette Hughes
    • , Evdoxia Kakani
    • , Joe Karbowski
    • , Angus Kitchell
    • , Erika Lee
    • , Teresa Lin
    • , Jianyi Liu
    • , Martin Lozano
    • , Warren MacDonald
    • , James W. Mains
    • , Matty Metlitz
    • , Sara N. Mitchell
    • , David Moore
    • , Johanna R. Ohm
    • , Kathleen Parkes
    • , Alexandra Porshnikoff
    • , Chris Robuck
    • , Martin Sheridan
    • , Robert Sobecki
    • , Peter Smith
    • , Jessica Stevenson
    • , Jordan Sullivan
    • , Brian Wasson
    • , Allison M. Weakley
    • , Mark Wilhelm
    • , Joshua Won
    • , Ari Yasunaga
    • , William C. Chan
    • , Jodi Holeman
    • , Nigel Snoad
    • , Linus Upson
    • , Tiantian Zha
    • , Stephen L. Dobson
    • , F. Steven Mulligan
    • , Peter Massaro
    •  & Bradley J. White
  • Article |

    A blocking assay based on the recombinant receptor-binding domain of SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 receptor provides an alternative to conventional antibody neutralization assays requiring live virus.

    • Chee Wah Tan
    • , Wan Ni Chia
    • , Xijian Qin
    • , Pei Liu
    • , Mark I.-C. Chen
    • , Charles Tiu
    • , Zhiliang Hu
    • , Vivian Chih-Wei Chen
    • , Barnaby E. Young
    • , Wan Rong Sia
    • , Yee-Joo Tan
    • , Randy Foo
    • , Yongxiang Yi
    • , David C. Lye
    • , Danielle E. Anderson
    •  & Lin-Fa Wang
  • Author Correction |

    • Justin M. Zook
    • , Nancy F. Hansen
    • , Nathan D. Olson
    • , Lesley Chapman
    • , James C. Mullikin
    • , Chunlin Xiao
    • , Stephen Sherry
    • , Sergey Koren
    • , Adam M. Phillippy
    • , Paul C. Boutros
    • , Sayed Mohammad E. Sahraeian
    • , Vincent Huang
    • , Alexandre Rouette
    • , Noah Alexander
    • , Christopher E. Mason
    • , Iman Hajirasouliha
    • , Camir Ricketts
    • , Joyce Lee
    • , Rick Tearle
    • , Ian T. Fiddes
    • , Alvaro Martinez Barrio
    • , Jeremiah Wala
    • , Andrew Carroll
    • , Noushin Ghaffari
    • , Oscar L. Rodriguez
    • , Ali Bashir
    • , Shaun Jackman
    • , John J. Farrell
    • , Aaron M. Wenger
    • , Can Alkan
    • , Arda Soylev
    • , Michael C. Schatz
    • , Shilpa Garg
    • , George Church
    • , Tobias Marschall
    • , Ken Chen
    • , Xian Fan
    • , Adam C. English
    • , Jeffrey A. Rosenfeld
    • , Weichen Zhou
    • , Ryan E. Mills
    • , Jay M. Sage
    • , Jennifer R. Davis
    • , Michael D. Kaiser
    • , John S. Oliver
    • , Anthony P. Catalano
    • , Mark J. P. Chaisson
    • , Noah Spies
    • , Fritz J. Sedlazeck
    •  & Marc Salit
  • Brief Communication |

    The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis.

    • Michael A. Skinnider
    • , Jordan W. Squair
    • , Claudia Kathe
    • , Mark A. Anderson
    • , Matthieu Gautier
    • , Kaya J. E. Matson
    • , Marco Milano
    • , Thomas H. Hutson
    • , Quentin Barraud
    • , Aaron A. Phillips
    • , Leonard J. Foster
    • , Gioele La Manno
    • , Ariel J. Levine
    •  & Grégoire Courtine
  • Resource
    | Open Access

    More than 200,000 gut prokaryotic reference genomes and the proteins they encode are collated, providing comprehensive resources for microbiome researchers.

    • Alexandre Almeida
    • , Stephen Nayfach
    • , Miguel Boland
    • , Francesco Strozzi
    • , Martin Beracochea
    • , Zhou Jason Shi
    • , Katherine S. Pollard
    • , Ekaterina Sakharova
    • , Donovan H. Parks
    • , Philip Hugenholtz
    • , Nicola Segata
    • , Nikos C. Kyrpides
    •  & Robert D. Finn
  • Author Correction |

    • Jim Aitken
    • , Karen Ambrose
    • , Sam Barrell
    • , Rupert Beale
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Richard Byrne
    • , Simon Caidan
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Margaret Crawford
    • , Laura Cubitt
    • , Vicky Dearing
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Efthymios Fidanis
    • , Alessandra Gaiba
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Jacki Goldman
    • , Robert Goldstone
    • , Paul R. Grant
    • , Maria Greco
    • , Judith Heaney
    • , Steve Hindmarsh
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Michael Hubank
    • , Deborah Hughes
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Stuart Kirk
    • , Svend Kjaer
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Wei-Ting Lu
    • , James I. MacRae
    • , John Matthews
    • , Laura E. McCoy
    • , Catherine Moore
    • , David Moore
    • , Eleni Nastouli
    • , Jerome Nicod
    • , Luke Nightingale
    • , Jessica Olsen
    • , Nicola O’Reilly
    • , Amar Pabari
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Nigel Peat
    • , Marc Pollitt
    • , Peter Ratcliffe
    • , Caetano Reis e Sousa
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Chloe Roustan
    • , Andrew Rowan
    • , Gee Yen Shin
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Amy Strange
    • , Charles Swanton
    • , James M. A. Turner
    • , Melanie Turner
    • , Andreas Wack
    • , Philip A. Walker
    • , Sophia Ward
    • , Wai Keong Wong
    • , Joshua Wright
    • , Mary Wu
    • , Jim Aitken
    • , Zoe Allen
    • , Rachel Ambler
    • , Karen Ambrose
    • , Emma Ashton
    • , Alida Avola
    • , Samutheswari Balakrishnan
    • , Caitlin Barns-Jenkins
    • , Genevieve Barr
    • , Sam Barrell
    • , Souradeep Basu
    • , Rupert Beale
    • , Clare Beesley
    • , Nisha Bhardwaj
    • , Shahnaz Bibi
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Michael J. Blackman
    • , Dominique Bonnet
    • , Faye Bowker
    • , Malgorzata Broncel
    • , Claire Brooks
    • , Michael D. Buck
    • , Andrew Buckton
    • , Timothy Budd
    • , Alana Burrell
    • , Louise Busby
    • , Claudio Bussi
    • , Simon Butterworth
    • , Fiona Byrne
    • , Richard Byrne
    • , Simon Caidan
    • , Joanna Campbell
    • , Johnathan Canton
    • , Ana Cardoso
    • , Nick Carter
    • , Luiz Carvalho
    • , Raffaella Carzaniga
    • , Natalie Chandler
    • , Qu Chen
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Bobbi Clayton
    • , Clementina Cobolli Gigli
    • , Zena Collins
    • , Sally Cottrell
    • , Margaret Crawford
    • , Laura Cubitt
    • , Tom Cullup
    • , Heledd Davies
    • , Patrick Davis
    • , Dara Davison
    • , Vicky Dearing
    • , Solene Debaisieux
    • , Monica Diaz-Romero
    • , Alison Dibbs
    • , Jessica Diring
    • , Paul C. Driscoll
    • , Annalisa D’Avola
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Dimitrios Evangelopoulos
    • , Rupert Faraway
    • , Antony Fearns
    • , Aaron Ferron
    • , Efthymios Fidanis
    • , James Fleming
    • , Bruno Frederico
    • , Alessandra Gaiba
    • , Anthony Gait
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Liam Gaul
    • , Helen M. Golding
    • , Jacki Goldman
    • , Robert Goldstone
    • , Belen Gomez Dominguez
    • , Hui Gong
    • , Paul R. Grant
    • , Maria Greco
    • , Mariana Grobler
    • , Anabel Guedan
    • , Maximiliano G. Gutierrez
    • , Fiona Hackett
    • , Ross Hall
    • , Steinar Halldorsson
    • , Suzanne Harris
    • , Sugera Hashim
    • , Lyn Healy
    • , Judith Heaney
    • , Susanne Herbst
    • , Graeme Hewitt
    • , Theresa Higgins
    • , Steve Hindmarsh
    • , Rajnika Hirani
    • , Joshua Hope
    • , Elizabeth Horton
    • , Beth Hoskins
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Louise Howitt
    • , Jacqueline Hoyle
    • , Mint R. Htun
    • , Michael Hubank
    • , Hector Huerga Encabo
    • , Deborah Hughes
    • , Jane Hughes
    • , Almaz Huseynova
    • , Ming-Shih Hwang
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Lucy Jenkins
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Louise Kiely
    • , Anastacio King Spert Teixeira
    • , Stuart Kirk
    • , Svend Kjaer
    • , Ellen Knuepfer
    • , Nikita Komarov
    • , Paul Kotzampaltiris
    • , Konstantinos Kousis
    • , Tammy Krylova
    • , Ania Kucharska
    • , Robyn Labrum
    • , Catherine Lambe
    • , Michelle Lappin
    • , Stacey-Ann Lee
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Hon Wing Liu
    • , Sam Loughlin
    • , Wei-Ting Lu
    • , James I. MacRae
    • , Akshay Madoo
    • , Julie A. Marczak
    • , Mimmi Martensson
    • , Thomas Martinez
    • , Bishara Marzook
    • , John Matthews
    • , Joachim M. Matz
    • , Samuel McCall
    • , Laura E. McCoy
    • , Fiona McKay
    • , Edel C. McNamara
    • , Carlos M. Minutti
    • , Gita Mistry
    • , Miriam Molina-Arcas
    • , Beatriz Montaner
    • , Kylie Montgomery
    • , Catherine Moore
    • , David Moore
    • , Anastasia Moraiti
    • , Lucia Moreira-Teixeira
    • , Joyita Mukherjee
    • , Cristina Naceur-Lombardelli
    • , Eleni Nastouli
    • , Aileen Nelson
    • , Jerome Nicod
    • , Luke Nightingale
    • , Stephanie Nofal
    • , Paul Nurse
    • , Savita Nutan
    • , Caroline Oedekoven
    • , Anne O’Garra
    • , Jean D. O’Leary
    • , Jessica Olsen
    • , Olga O’Neill
    • , Nicola O’Reilly
    • , Paula Ordonez Suarez
    • , Neil Osborne
    • , Amar Pabari
    • , Aleksandra Pajak
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Yogen Patel
    • , Oana Paun
    • , Nigel Peat
    • , Laura Peces-Barba Castano
    • , Ana Perez Caballero
    • , Jimena Perez-Lloret
    • , Magali S. Perrault
    • , Abigail Perrin
    • , Roy Poh
    • , Enzo Z. Poirier
    • , James M. Polke
    • , Marc Pollitt
    • , Lucia Prieto-Godino
    • , Alize Proust
    • , Clinda Puvirajasinghe
    • , Christophe Queval
    • , Vijaya Ramachandran
    • , Abhinay Ramaprasad
    • , Peter Ratcliffe
    • , Laura Reed
    • , Caetano Reis e Sousa
    • , Kayleigh Richardson
    • , Sophie Ridewood
    • , Fiona Roberts
    • , Rowenna Roberts
    • , Angela Rodgers
    • , Pablo Romero Clavijo
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Alice Rossi
    • , Chloe Roustan
    • , Andrew Rowan
    • , Erik Sahai
    • , Aaron Sait
    • , Katarzyna Sala
    • , Theo Sanderson
    • , Pierre Santucci
    • , Fatima Sardar
    • , Adam Sateriale
    • , Jill A. Saunders
    • , Chelsea Sawyer
    • , Anja Schlott
    • , Edina Schweighoffer
    • , Sandra Segura-Bayona
    • , Rajvee Shah Punatar
    • , Joe Shaw
    • , Gee Yen Shin
    • , Mariana Silva Dos Santos
    • , Margaux Silvestre
    • , Matthew Singer
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Louisa Steel
    • , Amy Strange
    • , Adrienne E. Sullivan
    • , Charles Swanton
    • , Michele S. Y. Tan
    • , Zoe H. Tautz-Davis
    • , Effie Taylor
    • , Gunes Taylor
    • , Harriet B. Taylor
    • , Alison Taylor-Beadling
    • , Fernanda Teixeira Subtil
    • , Berta Terré Torras
    • , Patrick Toolan-Kerr
    • , Francesca Torelli
    • , Tea Toteva
    • , Moritz Treeck
    • , Hadija Trojer
    • , Ming-Han C. Tsai
    • , James M. A. Turner
    • , Melanie Turner
    • , Jernej Ule
    • , Rachel Ulferts
    • , Sharon P. Vanloo
    • , Selvaraju Veeriah
    • , Subramanian Venkatesan
    • , Karen Vousden
    • , Andreas Wack
    • , Claire Walder
    • , Philip A. Walker
    • , Yiran Wang
    • , Sophia Ward
    • , Catharina Wenman
    • , Luke Williams
    • , Matthew J. Williams
    • , Wai Keong Wong
    • , Joshua Wright
    • , Mary Wu
    • , Lauren Wynne
    • , Zheng Xiang
    • , Melvyn Yap
    • , Julian A. Zagalak
    • , Davide Zecchin
    •  & Rachel Zillwood
  • Article |

    Improved Cas12a variants and sgRNA design rules enhance genome-wide screens.

    • Peter C. DeWeirdt
    • , Kendall R. Sanson
    • , Annabel K. Sangree
    • , Mudra Hegde
    • , Ruth E. Hanna
    • , Marissa N. Feeley
    • , Audrey L. Griffith
    • , Teng Teng
    • , Samantha M. Borys
    • , Christine Strand
    • , J. Keith Joung
    • , Benjamin P. Kleinstiver
    • , Xuewen Pan
    • , Alan Huang
    •  & John G. Doench
  • Article |

    Off-the-shelf CAR T cells avoid immune rejection in mouse models of allogeneic cancer cell therapy.

    • Feiyan Mo
    • , Norihiro Watanabe
    • , Mary K. McKenna
    • , M. John Hicks
    • , Madhuwanti Srinivasan
    • , Diogo Gomes-Silva
    • , Erden Atilla
    • , Tyler Smith
    • , Pinar Ataca Atilla
    • , Royce Ma
    • , David Quach
    • , Helen E. Heslop
    • , Malcolm K. Brenner
    •  & Maksim Mamonkin
  • Patents |

    Recent patents related to CRISPR-based gene editing, disease treatment and methods for targeting nucleic acids.

  • People |

    Recent moves of note in and around the biotech and pharma industries.

  • Editorial |

    As CRISPR–Cas9 enters human testing, the blistering pace of progress in preclinical research is offering a bewildering array of options for therapeutic gene editing.

  • News |

    Coronavirus is instigating new thinking in diagnostics, such as face masks that can detect viruses on a wearer’s breath or paper-based microfluidics for pathogen identification in low-resource settings.

    • Cormac Sheridan
  • Building a Business |

    Ask any pharma executive whether their company is interested in academic collaborations and the answer is a resounding “yes.” So why do so few academic institutions have success stories to share?

    • Juan Carlos López
  • Patents |

    Obtaining patent protection for microbiome therapeutics has been affected profoundly by the US Supreme Court decisions in Myriad and Mayo, which redefined the scope of which natural phenomena, including microbiome therapeutics, are patent eligible.

    • Mark J. FitzGerald
    •  & Erik J. Spek
  • Letter |

    The activity of adenine or cytosine base editors at specific target nucleotides is predicted computationally.

    • Myungjae Song
    • , Hui Kwon Kim
    • , Sungtae Lee
    • , Younggwang Kim
    • , Sang-Yeon Seo
    • , Jinman Park
    • , Jae Woo Choi
    • , Hyewon Jang
    • , Jeong Hong Shin
    • , Seonwoo Min
    • , Zhejiu Quan
    • , Ji Hun Kim
    • , Hoon Chul Kang
    • , Sungroh Yoon
    •  & Hyongbum Henry Kim
  • Article |

    Water contaminants are detected with freeze-dried, regulated in vitro transcription reactions.

    • Jaeyoung K. Jung
    • , Khalid K. Alam
    • , Matthew S. Verosloff
    • , Daiana A. Capdevila
    • , Morgane Desmau
    • , Phillip R. Clauer
    • , Jeong Wook Lee
    • , Peter Q. Nguyen
    • , Pablo A. Pastén
    • , Sandrine J. Matiasek
    • , Jean-François Gaillard
    • , David P. Giedroc
    • , James J. Collins
    •  & Julius B. Lucks
  • Feature |

    Investment and funding has continued to flow into biotech, unlike most business sectors. But with healthcare and hospital budgets increasingly under pressure, do belt-tightening and consolidation lie ahead? Melanie Senior investigates, with additional reporting by Riku Lähteenmäki.

    • Melanie Senior
  • Review Article |

    As CRISPR therapies move into clinical testing, David Schaffer and colleagues review a raft of different delivery technologies being road tested to address cargo capacity limitations, maximize potency, minimize off-target effects and avoid immunogenicity.

    • Joost van Haasteren
    • , Jie Li
    • , Olivia J. Scheideler
    • , Niren Murthy
    •  & David V. Schaffer