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Biotech is embracing insect protein as a meat alternative. Will the rest of the population follow?

A systematic examination of eight different single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) technologies revealed marked differences in the complexity of sequencing libraries and the specificity of DNA tagmentation that they achieve. Our pipeline for universal mapping of scATAC-seq data (PUMATAC) allowed a fair benchmarking of existing methods and enables the seamless integration of future datasets and technologies.

Benchmarking of scATAC-seq protocols demonstrates the effects of data quality on downstream analyses.

A dual illumination method reduces photobleaching for green and yellow fluorescent proteins.

Targeted protein degradation of cell-surface glycoproteins suppresses cancer in mice.

A small molecule enhances targeted gene integration at therapeutically relevant loci in human primary cells.

A refined velocity model improves cell fate mapping with lineage-traced scRNA-seq data.

Large, updatable phylogenetic trees are constructed using a divide-and-conquer strategy.

A comprehensive microbial resource reconciles genomic and 16S rRNA data in a single tree.

Harnessing the unusual biology of bats, researchers aim to turn drug discovery upside-down.

Old or diseased human glial cells in the chimeric mouse brain are eliminated by transplanted young cells.

Recent patents relating to machine learning in drug discovery and screening.