Aims & Scope

Nature Biotechnology is a monthly journal covering the science and business of biotechnology. It publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research. The first function is fulfilled by the peer-reviewed research section, the second by the expository efforts in the front of the journal. We provide researchers with news about business; we provide the business community with news about research developments.

The core areas in which we are actively seeking research papers include: molecular engineering of nucleic acids and proteins; molecular therapy (therapeutics genes, antisense, siRNAs, aptamers, DNAzymes, ribozymes, peptides, proteins); large-scale biology (genomics, functional genomics, proteomics, structural genomics, metabolomics, etc.); computational biology (algorithms and modeling), regenerative medicine (stem cells, tissue engineering, biomaterials); imaging technology; analytical biotechnology (sensors/detectors for analytes/macromolecules), applied immunology (antibody engineering, xenotransplantation, T-cell therapies); food and agricultural biotechnology; and environmental biotechnology. A comprehensive list of areas of interest is shown below.

Genetic engineering

  • Strategies for controlling gene expression
  • Strategies for manipulating gene structure
  • Strategies for gene containment

Large-scale approaches

  • Technologies for analyzing gene function (e.g., arrays, SAGE)
  • Technologies for analyzing gene structure/organization (e.g., molecular beacons)
  • Chemogenomics or chemical genetics
  • Pharmacogenomics/SNPs
  • Computational analysis


  • Technologies for analyzing/identifying protein structure/function (e.g., 2-D gels, mass spectrometry, yeast two-hybrid, SPR, NMR, arrays and chips)
  • Structural genomics
  • Computational analysis


  • Technologies for analyzing/profiling metabolites (chromatography, mass spectrometry)
  • Computational analysis

Computational biology

  • Bioinformatics; algorithms; data deconvolution
  • Modeling and systems biology: kinetics-based models and constraints-based models

Molecular engineering

  • Rational approaches for proteins/antibodies/enzymes/drugs
  • Molecular evolution
  • Molecular breeding approaches

Metabolic engineering

  • Genetic manipulation of species of interest to modify or allow the production of a commercially or therapeutically relevant compound
  • Computational analysis

Novel expression systems

  • Mammalian cells
  • Insect cells
  • Bacteria
  • Fungi
  • Plant cells

Delivery of genes, drugs, or cells

  • Targeting strategies
  • Viral and nonviral vector strategies


  • Reporter molecules
  • Imaging approaches/technologies for visualizing whole animals, cells, or single molecules
  • Computational analysis

Nucleic acid therapeutics

  • Gene therapy (targeting, expression, integration, immunogenicity)
  • Antisense
  • RNAi
  • DNAzymes and ribozymes
  • Other (e.g., chimeric oligonucleotides/triple helix)


  • Nanomaterials for use in drug delivery or as therapeutics
  • Nanomaterials for use in industrial biotechnology
  • Nanosensors
  • Nanosystems for imaging molecules and cells

Vaccines and applied immunology

  • Antibody engineering
  • T-cell therapies
  • Therapies exploiting innate immunity (e.g. complement)
  • Antigen delivery vectors and approaches
  • Nucleic acid vaccines
  • Computational analysis

Regenerative medicine

  • Stem cells
  • Tissue engineering
  • Therapeutic cloning (somatic cell nuclear transfer)
  • Xenotransplantation
  • Biomaterials


  • Approaches for detecting biological molecules
  • Use of biological systems in detecting analytes

Assay systems

  • Approaches for multiplexing and increasing throughput
  • Selection/screening strategies for gene/proteins/drugs
  • Microfluidics


  • Engineering materials for biological application
  • Molecular imprinting
  • Biomimetics
  • Nanotechnology

Agbiotech and transgenic plants

  • Crop improvement (resistance to stress, disease, pests)
  • Nutraceuticals
  • Forest biotechnology
  • Plant vaccines
  • Plants as bioreactors
  • Gene-containment strategies


  • Transgenic animals
  • Knockouts
  • Reproductive cloning
  • Biopharmaceutical and enzyme production
  • Transgene targeting and expression strategies


  • Bioremediation
  • Biomining
  • Phytoremediation
  • Monitoring