Nature Biotechnology

Algae-encoded biopharmaceuticals

Spirulina is used to manufacture a therapeutic antibody against campylobacter

Current issue

Knock-in on CRISPR’s door

Editorial 07 Jun 2022
Unconventional γδ T cells ‘the new black’ in cancer therapy

Elie Dolgin
News 15 Jun 2022
Caribou’s first CRISPR CAR-T impresses

News in Brief 15 Jun 2022
The clinical progress of mRNA vaccines and immunotherapies

Ann J. Barbier
Allen Yujie Jiang
Daniel G. Anderson
Review Article 09 May 2022
Cell types of origin of the cell-free transcriptome

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
Brief Communication Open Access 07 Feb 2022
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

Francisco J. Sánchez-Rivera
Bianca J. Diaz
Lukas E. Dow
Article 14 Feb 2022

Contents

View all issues

Announcements

Bioengineering Solutions for Biology and Medicine

Submit your abstract to Bioengineering Solutions for Biology and Medicine 2022. The Nature conference, which will be broadcast online, will highlight innovations in bioengineering and artificial intelligence, with a focus on technologies that promise tangible solutions for urgent medical needs.
Nature Conference: RNA at the Bench and Bedside III

The third in a series of Nature Conferences highlighting the way RNA medicines continue to change the face of clinical practice. This conference explores progress in our understanding of the roles of RNAs in immune signaling and chronic disease associated with dysregulated inflammatory processes.
We are seeking an Immunologist

Nature Biotechnology currently has an open position for a talented immunologist to join the team as an Associate or Senior Editor. The deadline for applications is June 20, 2022.

Nature Biotechnology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Latest Research articles

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer

Cancer driver mutations are identified by predicting neutral mutation rates across the entire genome.

Maxwell A. Sherman
Adam U. Yaari
Bonnie Berger
Article Open Access 20 Jun 2022
Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds

Biosensors are developed from malleable hormone receptors.

Jesús Beltrán
Paul J. Steiner
Timothy A. Whitehead
Article Open Access 20 Jun 2022
A red light–responsive photoswitch for deep tissue optogenetics

A photoswitch based on a bacterial phytochrome enables optogenetic manipulations using red light.

Yuto Kuwasaki
Kazushi Suzuki
Moritoshi Sato
Article 13 Jun 2022
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression

Total mRNA expression in cancer cells is a marker for disease progression and death.

Shaolong Cao
Jennifer R. Wang
Wenyi Wang
Article Open Access 13 Jun 2022
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR

The T cell response to SARS-CoV-2 is detected by a PCR assay on whole blood.

Megan Schwarz
Denis Torre
Ernesto Guccione
Article 13 Jun 2022
Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping

ALPHA-FSS enables high-resolution imaging deep in the mouse brain.

Zhongya Qin
Zhentao She
Jianan Y. Qu
Article 13 Jun 2022

Latest Reviews & Analysis

- Plant hormone sensors as scaffolds for biosensor design
  
  Most plant hormone sensors, including the abscisic acid receptor PYR1, function through chemically induced dimerization. Using computationally designed libraries of PYR1, we created high-affinity receptors for 21 structurally diverse ligands, setting the stage for large-scale small-molecule biosensor development
  
  Research Briefing 20 Jun 2022
- Smartphone apps in the COVID-19 pandemic
  
  An overview of apps for outbreak epidemiology, individual screening and contact tracing during the COVID-19 pandemic.
  Jay A. Pandit
  Jennifer M. Radin
  Eric J. Topol
  
  Review Article 20 Jun 2022
- Measuring SARS-CoV-2 T cell immunity with a scalable qPCR-based assay
  
  We developed two quantitative PCR-based assays to detect SARS-CoV-2-specific T cell immunity: qTACT and dqTACT. The assays quantify CXCL10 mRNA, after incubation of whole blood with viral peptides, as a proxy of an antigen-specific T cell response, and will allow population-level monitoring of cellular immunity to SARS-CoV-2.
  
  Research Briefing 17 Jun 2022
- Towards the non-invasive imaging of brain networks and functions at high resolution
  
  A new study describes a microscope combining three-photon excitation and adaptive optics capable of high-resolution in vivo imaging of fine neuronal structures in the mouse cortex through the intact skull. The authors demonstrate the use of this platform to guide precise laser-mediated microsurgery and for accurate and sensitive functional calcium imaging.
  
  Research Briefing 13 Jun 2022
- CRISPR comes a-knock-in to reprogram antibodies in vivo
  
  Reprogramming of antibody responses in mice is achieved via adeno-associated virus delivery of SaCas9, single guide RNA (sgRNA) and a repair template targeting immunoglobulin genes.
  Harald Hartweger
  Michel C. Nussenzweig
  
  News & Views 09 Jun 2022
- Lipophilic siRNA conjugates yield durable silencing in extrahepatic tissues
  
  Research Briefing 08 Jun 2022
- Visualization of living cells and tissues in many colors
  
  Research Briefing 06 Jun 2022
- First liver transplantation using a graft maintained ex vivo for several days
  
  Research Briefing 06 Jun 2022
- Team architecture in 3D genomic interactions revealed through nanopore sequencing
  
  Research Briefing 01 Jun 2022

News & Comment

Forum: Phillips-Cremins and Pombo

Podcast 15 Jun 2022
Biotech news from around the world

News in Brief 15 Jun 2022
AI’s plastic recycling

News in Brief 15 Jun 2022
CRISPR technology

Recent patents relating to CRISPR methods and compositions for gene editing and therapeutic use.

Patents 15 Jun 2022
Egg without the chicken

Lisa Melton
News 15 Jun 2022
Caribou’s first CRISPR CAR-T impresses

News in Brief 15 Jun 2022