Image: Chantal Ferguson

A human genome graph for rapid genotyping

A graph-based genome indexing scheme enables variant-aware alignment of sequences with very low memory requirements.

Latest Research

  • Article |

    High-fidelity reads improve variant detection and genome assembly on the PacBio platform.

    • Aaron M. Wenger
    • , Paul Peluso
    • , William J. Rowell
    • , Pi-Chuan Chang
    • , Richard J. Hall
    • , Gregory T. Concepcion
    • , Jana Ebler
    • , Arkarachai Fungtammasan
    • , Alexey Kolesnikov
    • , Nathan D. Olson
    • , Armin Töpfer
    • , Michael Alonge
    • , Medhat Mahmoud
    • , Yufeng Qian
    • , Chen-Shan Chin
    • , Adam M. Phillippy
    • , Michael C. Schatz
    • , Gene Myers
    • , Mark A. DePristo
    • , Jue Ruan
    • , Tobias Marschall
    • , Fritz J. Sedlazeck
    • , Justin M. Zook
    • , Heng Li
    • , Sergey Koren
    • , Andrew Carroll
    • , David R. Rank
    •  & Michael W. Hunkapiller
  • Review Article |

    Anikeeva and colleagues review the state of the art in technologies that enable discoveries of brain function and the development of novel therapeutic approaches.

    • James A. Frank
    • , Marc-Joseph Antonini
    •  & Polina Anikeeva
  • Article |

    Cell therapy in a rat model of heart attack is enhanced by stem-cell-derived epicardium.

    • Johannes Bargehr
    • , Lay Ping Ong
    • , Maria Colzani
    • , Hongorzul Davaapil
    • , Peter Hofsteen
    • , Shiv Bhandari
    • , Laure Gambardella
    • , Nicolas Le Novère
    • , Dharini Iyer
    • , Fotios Sampaziotis
    • , Florian Weinberger
    • , Alessandro Bertero
    • , Andrea Leonard
    • , William G. Bernard
    • , Amy Martinson
    • , Nichola Figg
    • , Michael Regnier
    • , Martin R. Bennett
    • , Charles E. Murry
    •  & Sanjay Sinha
  • Article |

    A divalent siRNA architecture enables sustained silencing of gene expression in deep regions of the brain.

    • Julia F. Alterman
    • , Bruno M. D. C. Godinho
    • , Matthew R. Hassler
    • , Chantal M. Ferguson
    • , Dimas Echeverria
    • , Ellen Sapp
    • , Reka A. Haraszti
    • , Andrew H. Coles
    • , Faith Conroy
    • , Rachael Miller
    • , Loic Roux
    • , Paul Yan
    • , Emily G. Knox
    • , Anton A. Turanov
    • , Robert M. King
    • , Gwladys Gernoux
    • , Christian Mueller
    • , Heather L. Gray-Edwards
    • , Richard P. Moser
    • , Nina C. Bishop
    • , Samer M. Jaber
    • , Matthew J. Gounis
    • , Miguel Sena-Esteves
    • , Athma A. Pai
    • , Marian DiFiglia
    • , Neil Aronin
    •  & Anastasia Khvorova

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