Nature Biotechnology

A representation of cellular mRNA modified by m6A, which is depicted as a gemstone.

m⁶a modifications are measured in living cells with a fluorescent reporter

Current issue

Pandemic preparedness demands proper prioritization

Editorial05 Sept 2024
Foundation models build on ChatGPT tech to learn the fundamental language of biology

Michael Eisenstein
News13 Sept 2024
FDA approves first IDH-targeted glioma drug

News in Brief13 Sept 2024
A monomeric StayGold fluorescent protein

Esther Ivorra-Molla
Dipayan Akhuli
Mohan K. Balasubramanian
Brief CommunicationOpen Access11 Dec 2023
Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology

Daiwei Zhang
Amelia Schroeder
Mingyao Li
Brief Communication02 Jan 2024
High-quality metagenome assembly from long accurate reads with metaMDBG

Gaëtan Benoit
Sébastien Raguideau
Christopher Quince
Brief CommunicationOpen Access02 Jan 2024

Contents

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Announcements

Multiplexing in animal models to speed drug discovery

Companies are moving therapeutic testing from plastic wells into pooled in vivo screening, generating physiologically relevant data by screening many drug candidates at once in a single animal.
From Bench to Podcast: Stories from Biotech Labs

On this episode, Associate Editor Cláudia Vilhena interviews Nicoletta Cieri, first author of an article showing how a devised analytic framework can aid the prevention of post-transplant disease recurrence. Nicoletta and Cláudia explore the highlights of the story, discuss the future of individualized medicine and touch base on future career opportunites for postdocs.
Generative AI platforms drive drug discovery dealmaking

From Biopharma Dealmakers: Companies developing artificial intelligence-based platforms that enable the design of small-molecule and biologic drug candidates have been a focus of biopharma dealmaking in the past year.
Read the September issue of Biopharma Dealmakers

Our latest issue includes company profiles and editorial pieces covering innovations in oncology, CNS and artificial intelligence.

Nature Biotechnology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Latest Research articles

Bacteriophage λ exonuclease and a 5′-phosphorylated DNA guide allow PAM-independent targeting of double-stranded nucleic acids

A λ exonuclease system exhibits protospacer-adjacent motif-independent DNA-binding specificity, enabling diagnostic and imaging applications.

Shengnan Fu
Junjie Li
Xin Su
Article18 Sept 2024
An experimental census of retrons for DNA production and genome editing

Genome editing tools are developed through large-scale characterization of bacterial retrons.

Asim G. Khan
Matías Rojas-Montero
Seth L. Shipman
Article17 Sept 2024
Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration

Mouse stem cells that regenerate muscle are derived by organoid dedifferentiation of myoblasts.

Feodor D. Price
Mark N. Matyas
Lee L. Rubin
ArticleOpen Access11 Sept 2024
Efficient genetic code expansion without host genome modifications

Noncanonical amino acids are efficiently incorporated into proteins by optimizing mRNA codon usage.

Alan Costello
Alexander A. Peterson
Ahmed H. Badran
Article11 Sept 2024
Continuous multiplexed phage genome editing using recombitrons

Phage genomes are readily engineered using retron recombineering.

Chloe B. Fishman
Kate D. Crawford
Seth L. Shipman
Article05 Sept 2024
Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells

Human hematopoietic cells derived from pluripotent cells repopulate multiple blood lineages in mice.

Elizabeth S. Ng
Gulcan Sarila
Andrew G. Elefanty
ArticleOpen Access02 Sept 2024

Latest Reviews & Analysis

- Targeting double-stranded nucleic acids using the λExo–pDNA system
  
  λ exonuclease (λExo) binds 5′-phosphorylated single-stranded DNA (pDNA) at complementary regions on double-stranded DNA and DNA–RNA duplexes under ambient conditions without a PAM-like motif. In the presence of Mg²⁺, λExo then digests the pDNA into nucleotides.
  
  Research Briefing18 Sept 2024
- A developmental route to hematopoietic stem cells
  
  A differentiation method informed by developmental biology converts human pluripotent stem cells to engraftable hematopoietic stem and progenitor cells without the use of transgenes.
  Adam C. Wilkinson
  Marella F. T. R. de Bruijn
  
  News & Views18 Sept 2024
- Recoded gene circuits for multiplexed genetic code expansion
  
  Quadruplet codons allow multiplexing of non-canonical amino acids within single polypeptides in living cells. We show that including high-usage triplet codons after quadruplet codons can improve their decoding efficiency in genetic circuits, which allowed us to develop a system for the programmable biosynthesis of exotic macrocyclic peptides in cells.
  
  Research Briefing11 Sept 2024
- Dedifferentiating myoblasts back into a satellite cell state in vitro
  
  Satellite cells, the stem cells of skeletal muscle, are responsible for muscle development and regeneration. Although low in abundance, satellite cells can be isolated from muscle but cannot be propagated successfully in culture in numbers needed for therapeutic use. We developed a method to generate cells with satellite cell characteristics from skeletal muscle organoid cultures.
  
  Research Briefing11 Sept 2024
- Phage genome engineering with retrons
  
  A method using retron recombineering for phage genome modification may facilitate access to therapeutic phages.
  Ilya Osterman
  Rotem Sorek
  
  News & Views09 Sept 2024
- Genome editing with DNA-dependent polymerases
  Quinn T. Cowan
  Alexis C. Komor
  
  News & Views23 Aug 2024
- Framework for predicting alloreactivity in hematopoietic cell transplants
  
  Research Briefing21 Aug 2024
- Small molecules self-organized in an orderly manner to enhance Raman signals
  
  Research Briefing21 Aug 2024
- Protein language model enables fast and sensitive remote homolog detection
  
  Research Briefing09 Aug 2024

News & Comment

Biotech news from around the world

News in Brief13 Sept 2024
FDA approves first IDH-targeted glioma drug

News in Brief13 Sept 2024
Engineered parasite delivers therapeutic proteins to the mouse brain

Iris Marchal
Research Highlight13 Sept 2024
Genentech, Sangamo ink Alzheimer’s deal

News in Brief13 Sept 2024
Biogenetic Blooms: it’s microbial, and it’s art

Daniel Grushkin
News13 Sept 2024
Targeting fatty acid metabolism promotes a healthy vaginal microbiome

Iris Marchal
Research Highlight13 Sept 2024

Collections

Navigating the vaccines landscape

We explore the latest developments in the vaccines field, through our editorial feature and showcase of companies.

Collection 03 Jun 2024

Trending - Altmetric

Science jobs

Postdoctoral Fellowships Worldwide

IBSA Foundation for scientific research offers 6 fellowships offers of € 32.000 to young researchers under 40 years.

The call is open to people from research institutes and universities from all over the world.

IBSA Foundation for scientific research
Assistant Professor in Forest Genetics

Assistant Professor position in Forest Genetics with focus on genetic biodiversity in relation to forestry at Umeå Plant Science Centre

Umeå (Kommun), Västerbotten (SE)

Swedish University of Agricultural Sciences (SLU)
Faculty Positions in School of Engineering, Westlake University

The School of Engineering (SOE) at Westlake University is seeking to fill multiple tenured or tenure-track faculty positions in all ranks.

Hangzhou, Zhejiang, China

Westlake University
Supervisory Bioinformatics Specialist CTG Program Head

The National Library of Medicine (NLM) is a global leader in biomedical informatics and computational health data science and the world’s largest b...

Bethesda, Maryland (US)

National Library of Medicine, National Center for Biotechnology Information
Career Opportunities at the Yazhouwan National Laboratory, Hainan, China

YNL recruits leading scientists in agriculture: crop/animal genetics, biotech, photosynthesis, disease resistance, data analysis, and more.

Sanya, Hainan, China

Yazhouwan National Laboratory

Announcements

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A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

Rapid customization of Solanaceae fruit crops for urban agriculture

Insect resistance management in GM crops: past, present and future

The Wild West of spike-in normalization

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