Nature Biotechnology

Massively parallel knock-in engineering of primary human T cells with an AAV library.

Large-scale knock-in T cell engineering

Current issue

When are your cells no longer your own?

Editorial12 Sept 2023
Hair loss treatments take aim at the immune system

Charlotte Harrison
News12 Sept 2023
FDA approves first-in-class bispecific for multiple myeloma

News in Brief12 Sept 2023
Wearable sensors for monitoring marine environments and their inhabitants

Altynay Kaidarova
Nathan R. Geraldi
Carlos M. Duarte
Perspective26 Jun 2023
Methodological concerns and lack of evidence for single-synapse RNA-seq

Benjamin D. Hobson
Etienne Herzog
Matters Arising27 Jul 2023
Reply to: Methodological concerns and lack of evidence for single-synapse RNA-seq

Muchun Niu
Chenghang Zong
Matters Arising27 Jul 2023

Contents

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Announcements

Conference: Cracking the Code

"Cracking the Code: The Dawn of Nucleic Acid Medicines" will discuss the development of nucleic acid medicines — both the recent clinical successes, and current and upcoming challenges. By bringing together academics in basic and translational research and their peers in thriving biotechnology companies and promising start-ups, the conference aims to foster dialog and to spearhead collaborations.
Drugs catch a ride through the blood–brain barrier

A new era of brain-penetrant therapies is opening up, as companies hook up drugs to transferrin receptors or use viral capsids to hitch a ride into previously inaccessible regions.
Seeking Associate or Senior Editor: News Features

We are seeking a highly motivated Associate or Senior Editor to join the Nature Biotechnology team as our News Features Editor. Your mission will be to build upon the success of the journal’s front-half section, commissioning, editing and developing content that analyzes and provides our readers with updates on the most timely and significant problems in biotechnology and bioengineering.

Nature Biotechnology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Latest Research articles

Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses

Killing bacteria in tumors boosts survival in a mouse model of colon cancer.

Menglin Wang
Benoit Rousseau
Leaf Huang
Article25 Sept 2023
Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes

Lineage tracing using both transcriptomics and chromatin accessibility provides mechanistic insights into cell fate.

Kunal Jindal
Mohd Tayyab Adil
Samantha A. Morris
ArticleOpen Access25 Sept 2023
Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens

mRNA kinetics are described by combining single-cell combinatorial indexing with metabolic labeling and pooled CRISPR screens.

Zihan Xu
Andras Sziraki
Junyue Cao
Brief CommunicationOpen Access25 Sept 2023
Supervised discovery of interpretable gene programs from single-cell data

Spectra decomposes gene expression data into interpretable programs using prior knowledge.

Russell Z. Kunes
Thomas Walle
Dana Pe’er
ArticleOpen Access21 Sept 2023
A DNA nanodevice for mapping sodium at single-organelle resolution

A probe reports absolute sodium levels in acidic organelles with single-organelle resolution.

Junyi Zou
Koushambi Mitra
Yamuna Krishnan
Article21 Sept 2023
Identification of mobile genetic elements with geNomad

geNomad identifies mobile genetic elements in sequencing data.

Antonio Pedro Camargo
Simon Roux
Nikos C. Kyrpides
ArticleOpen Access21 Sept 2023

Latest Reviews & Analysis

- Decoding the building blocks of cellular processes from single-cell transcriptomics data
  
  Most features of a cell are determined by gene programs — sets of co-expressed genes that execute a specific function. By incorporating existing knowledge about gene programs and cell types, the Spectra factor analysis method improves how we decode single-cell transcriptomic data and offers insights into challenging tumor immune contexts.
  
  Research Briefing21 Sept 2023
- Fast and accurate identification of plasmids and viruses in sequencing data using geNomad
  
  The detection of mobile genetic elements is crucial for exploring the ecology and evolution of microbial communities, and it has diverse implications in biotechnology and public health. geNomad is a computational framework that enables researchers to precisely identifiy and annotate plasmids and viruses in sequencing data on a large scale.
  
  Research Briefing21 Sept 2023
- Precision RNA base editing with engineered and endogenous effectors
  
  Pfeiffer and Stafforst review and discuss the state-of-the-art tools for precision editing of RNA bases.
  Laura S. Pfeiffer
  Thorsten Stafforst
  
  Review Article21 Sept 2023
- Electroosmotic flow across nanopores for single-molecule protein sequencing
  
  By using fixed charges to engineer a strong electroosmotic flow, we achieve the unidirectional transport of natural polypeptides across nanopores. Our approach enables native proteins to be transported enzymatically and non-enzymatically in the absence of denaturant and electrophoretic tags, with potential applications for protein sequencing.
  
  Research Briefing18 Sept 2023
- BugSigDB — a database for identifying unusual abundance patterns in human microbiome studies
  
  BugSigDB is a community-editable wiki that harmonizes how key microbial differential abundance methods and results are reported, identifying rare and common patterns across the literature of published host-associated microbiome studies.
  
  Research Briefing11 Sept 2023
- MaxFuse enables data integration across weakly linked spatial and single-cell modalities
  
  Research Briefing07 Sept 2023
- Genotoxicity concerns for base and prime editors in hematopoietic stem cells
  
  Research Briefing07 Sept 2023
- Survival of the fittest glia
  V. Alexandra Moser
  Clive N. Svendsen
  
  News & Views28 Aug 2023
- Machine learning predicts cellular response to genetic perturbation
  
  Research Briefing17 Aug 2023

News & Comment

From air to your plate: tech startups making food from atmospheric CO₂

Food tech companies are taking bacteria that capture CO₂ from air to make edible and nutritious food and drink.

Claire Turrell
News26 Sept 2023
Vector BioPharma: resurrecting adenoviral gene delivery

Two veteran protein engineers team up to create a new gene-delivery vehicle.

Laura DeFrancesco
News Feature26 Sept 2023
Peptone: finding opportunity in disorder

Combining experimental and computational tools, this company is targeting disordered regions of proteins previously thought to be undruggable.

Michael Eisenstein
News Feature19 Sept 2023
Pharma deal making: a bright spot amid the gloom

Biopharma M&A is back and IPOs are possible, but most biotechs aren’t out of the woods.

Melanie Senior
News Feature15 Sept 2023
A new chance for genome editing in Europe

Hervé Vanderschuren
Patience Chatukuta
Devang Mehta
Correspondence14 Sept 2023
Scalable genomic data exchange and analytics with sBeacon

Anuradha Wickramarachchi
Brendan Hosking
Denis C. Bauer
Correspondence14 Sept 2023

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Jobs

Recruitment of Global Talent at the Institute of Zoology, Chinese Academy of Sciences (IOZ, CAS)

The Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS), is seeking global talents around the world.

Beijing, China

Institute of Zoology, Chinese Academy of Sciences (IOZ, CAS)
CALL FOR EXPRESSION OF INTEREST – Team Leader in Meta-Research

University of Coimbra opens a call for one Team Leader Position, in the framework of the EXCELScIOR project

Portugal (PT)

University of Coimbra (UC)
(Marine) Microbiologist (m/f/d)

We are seeking a competent and experienced (marine) microbiologist support scientist (m/f/d) for Research Unit Marine Natural Product Chemistry.

Wischhofstraße 1-3, 24148 Kiel, Schleswig-Holstein (DE)

Helmholtz Centre for Ocean Research Kiel (GEOMAR)
Assistant Professor (Tenure Track) of Engineering Biomolecular Systems for Diagnostics

The Department of Biosystems Science and Engineering at ETH Zurich invites applications for the above-mentioned position.

Basel, Switzerland

ETH Zurich
Faculty Positions at State Key Laboratory of Primate Biomedical Research

State Key Laboratory of Primate Biomedical Research (LPBR) is a recognized institute for cutting-edge research on primate b...

Kunming,China

State Key Laboratory of Primate Biomedical Research (Kunming University of Science and Technology)

Announcements

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A DNA nanodevice for mapping sodium at single-organelle resolution

Detection of transcriptome-wide microRNA–target interactions in single cells with agoTRIBE

Detecting organelle-specific activity of potassium channels with a DNA nanodevice

Identification of mobile genetic elements with geNomad

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