The microbial composition of metagenomes is identified in seconds by profiling against large databases.

Phenotypic screens in organoids and primary cells are scaled up using perturbation pooling.

Optical pooled CRISPR screening is improved by combinatorial oligo hybridization for barcode detection.

SCOPE detects low-abundance extracellular vesicle mRNA with high sensitivity for clinical applications.

Optical pooled screening is enhanced by amplification of barcodes before in situ sequencing.

Bacteria expressing an anti-tumor cytokine act as a potent cancer immunotherapy.

The time has come for biotech companies to embrace machine learning for clinical trials, but they should start with compiling the data. That means grappling with real-world patient records.

The FDA’s approval of the first genetically modified T cell therapy for treating a rare sarcoma is paving the way for next-generation therapies that tackle other types of solid tumors.

Bacteria, fungi and plants can be grown and engineered to remove plastics, chemicals and pollutants from contaminated soil and water.