Our ranking of the top ten news stories we covered in 2023 is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashing GLP-1 agonist, with AI-hallucinated proteins a close second. These are followed by drugging options for RNA. The dark horses are virus-free gene therapies and a sweet protein.
Our annual survey highlights academic startups that are, among other things, correcting misfolded or disordered proteins, creating second generation GPCR agonists, building a new gene delivery platform, and mining cancer genomes for novel targets.