Image: Chantal Ferguson

Single-cell epigenomics scales up

Combining microfluidics with combinatorial indexing enables rapid mapping of genome accessibility in hundreds of thousands of single cells.

Latest Research

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    A DNA-based amplification scheme enables highly multiplexed immunofluorescence imaging

    • Sinem K. Saka
    • , Yu Wang
    • , Jocelyn Y. Kishi
    • , Allen Zhu
    • , Yitian Zeng
    • , Wenxin Xie
    • , Koray Kirli
    • , Clarence Yapp
    • , Marcelo Cicconet
    • , Brian J. Beliveau
    • , Sylvain W. Lapan
    • , Siyuan Yin
    • , Millicent Lin
    • , Edward S. Boyden
    • , Pascal S. Kaeser
    • , German Pihan
    • , George M. Church
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  • Letter |

    Mitochondrial DNA mutations in iPSCs can render them immunogenic.

    • Tobias Deuse
    • , Xiaomeng Hu
    • , Sean Agbor-Enoh
    • , Martina Koch
    • , Matthew H. Spitzer
    • , Alessia Gravina
    • , Malik Alawi
    • , Argit Marishta
    • , Bjoern Peters
    • , Zeynep Kosaloglu-Yalcin
    • , Yanqin Yang
    • , Raja Rajalingam
    • , Dong Wang
    • , Bjoern Nashan
    • , Rainer Kiefmann
    • , Hermann Reichenspurner
    • , Hannah Valantine
    • , Irving L. Weissman
    •  & Sonja Schrepfer
  • Article |

    High-fidelity reads improve variant detection and genome assembly on the PacBio platform.

    • Aaron M. Wenger
    • , Paul Peluso
    • , William J. Rowell
    • , Pi-Chuan Chang
    • , Richard J. Hall
    • , Gregory T. Concepcion
    • , Jana Ebler
    • , Arkarachai Fungtammasan
    • , Alexey Kolesnikov
    • , Nathan D. Olson
    • , Armin Töpfer
    • , Michael Alonge
    • , Medhat Mahmoud
    • , Yufeng Qian
    • , Chen-Shan Chin
    • , Adam M. Phillippy
    • , Michael C. Schatz
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    • , Jue Ruan
    • , Tobias Marschall
    • , Fritz J. Sedlazeck
    • , Justin M. Zook
    • , Heng Li
    • , Sergey Koren
    • , Andrew Carroll
    • , David R. Rank
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  • Review Article |

    Anikeeva and colleagues review the state of the art in technologies that enable discoveries of brain function and the development of novel therapeutic approaches.

    • James A. Frank
    • , Marc-Joseph Antonini
    •  & Polina Anikeeva
  • Article |

    Cell therapy in a rat model of heart attack is enhanced by stem-cell-derived epicardium.

    • Johannes Bargehr
    • , Lay Ping Ong
    • , Maria Colzani
    • , Hongorzul Davaapil
    • , Peter Hofsteen
    • , Shiv Bhandari
    • , Laure Gambardella
    • , Nicolas Le Novère
    • , Dharini Iyer
    • , Fotios Sampaziotis
    • , Florian Weinberger
    • , Alessandro Bertero
    • , Andrea Leonard
    • , William G. Bernard
    • , Amy Martinson
    • , Nichola Figg
    • , Michael Regnier
    • , Martin R. Bennett
    • , Charles E. Murry
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