Mosaic data integration is improved by capturing features that do not overlap between datasets.

Reference mapping is extended beyond scRNA-seq to single-cell epigenetic and proteomic data.

A sequencing chemistry that separates nucleotide identification from nucleotide incorporation achieves high accuracy.

A cancer vaccine is delivered to the lung by an engineered attenuated influenza virus.

Bacteria and viruses are simultaneously quantified in gut metagenomic samples.

GlycoRNA imaging in cells is enabled with a proximity ligation assay.

The GLP-1 agonist Wegovy has re-energized the hunt for obesity treatments. Alternatives — ranging from bitter taste compounds to lean muscle boosters and bacteria — are already in the clinic.

Genetic engineering and accelerated evolution of microbes aim to help climate change.

Small molecules that target messenger RNA have therapeutic potential, but the field still lacks an unqualified success. Companies differ on how to move the resurgent field forward.