Full-funded postdoc position in genome maintenance at the Novo Nordisk Foundation Center for Protein Research

Full-funded postdoc position in genome maintenance at the Novo Nordisk Foundation Center for Protein Research

Choudhary Group at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen

Copenhagen, Denmark

A highly attractive postdoctoral position is available in the Choudhary Group at the Novo Nordisk Foundation Center for Protein Research (CPRwww.cpr.ku.dk), University of Copenhagen.

About the Choudhary group and CPR
The “Proteomics and Cell Signaling” group at CPR is led by Professor Chunaram Choudhary. The Choudhary group combines quantitative proteomics, cell biology and biochemistry to investigate cell signaling at a “systems-level” and to identify novel regulatory mechanisms in cell signaling.

The group applies cutting-edge mass spectrometry (MS)-based technologies for unbiased identification and quantification of posttranslational modifications, such as ubiquitylation, phosphorylation and acetylation (Narita et al. Nat Rev Mol Cell Biol 2019; Weinert and Narita et al., Cell 2018; Scholz et al., Nat Biotech 2015; Choudhary et al., Nat Rev Mol cell Biol 2014 and 2010; Weinert et al., Mol Cell 2013; Povlsen and Beli et al., Nat Cell Biol 2012; Beli et al. Mol Cell 2012; Choudhary et al. Science 2009). Furthermore, the group uses CRISPR-based genome editing for functional investigations and for mapping protein-protein interactions in the context of chromatin-associated processes, such as cell division and DNA damage repair (Gupta et al., Cell 2018; Thorslund et al., Nature 2015; Wild et al., Cell Rep 2016 and 2018). In addition to the state-of-the-art mass spectrometry, the laboratory is equipped with the cutting-edge infrastructure for molecular biology, cell biology and biochemistry work.

CPR offers the latest technologies and expertise for quantitative proteomics, the next-generation nucleic acid sequencing, high-resolution microscopy, live cell imaging, as well as biophysical and structural characterization of proteins, including Cryo-EM. Our group is technically and internationally diverse and embedded in excellent environment for high-quality research and collaboration. The group consistently publishes in top-ranked journals and has an outstanding track-record in training the next generation of researchers (more than 50% of former postdocs from the group were recruited as independent investigators at top-ranked institutes). The group collaborates with top-level international researchers and works closely with other groups at CPR, especially with the “Clinical Proteomics” group led by Prof. Matthias Mann.

Project description
The candidate will use a combination of the cutting-edge proteomics and CRSPR-based genome editing methods to investigate signaling networks of proteins involved in chromatin-associated processes, such as DNA damage repair and replication. Among other tasks, this will include CRISPR-based generation of genetically modified human cell lines, affinity-tagging of endogenous proteins, and mass spectrometry-based analysis of protein-protein interactions. The candidate is expected to apply various biochemical and molecular biology approaches for biological follow-up experiments on novel and interesting findings derived from large-scale proteomic screens.

Tentative start date: Summer 2019.

Qualifications
The candidate should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research, and show good inter-personal and communication skills.

The candidate is required to have a PhD degree or equivalent in natural or medical science. Excellent scientific track-record, including at least one publication as first author in a high-quality, peer reviewed international journal. Expert knowledge in one or more of the following areas would be considered an advantage: Analysis of cell signaling with biochemistry and molecular biology approaches Genetics and cell biology CRISPR-based genome editing Analysis of large-scale proteomic and/or genomic dataset Genome integrity, DNA damage repair, DNA replication, chromatin biology Prior experience in high resolution mass spectrometry is not essential. Good communication skills, both oral and written. An analytical aptitude for devising innovative scientific or technical solutions. Demonstrate enthusiasm, motivation, flexibility and confidence.

Questions
For further information, please contact Professor Chunaram Choudhary by email: chuna.choudhary@cpr.ku.dk.

Place of employment and work
The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. In the past 10 years, CPR has established itself as a top-level research institute in protein signaling and network biology research. The research environment at CPR is ambitious and international, with approx. 30 different nationalities currently represented. The Center comprises modern laboratories, supercomputer resources and state-of-the-art facilities within protein science, including microscopy, cryo-EM, and the next generation sequencing. Seminars with high-profile international speakers and regular internal research seminars are organized at the Center.

Denmark is often ranked as the happiest nation and Copenhagen is consistently ranked as one of the best cities for living. For more information on working and living in Denmark visit www.ism.ku.dk (International staff mobility) and https://www.workindenmark.dk.

Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary is approx. 34,079 DKK (approx. 4,543 €) plus 17.1 % in pension contribution.

The Danish Ministry of Finance and the Danish Confederation of Professional Associations (AC) have agreed on a protocol that makes it possible for all international researchers employed by the University to achieve a pension exemption, where the pension will be paid out as salary. For more information about the different pension schemes https://ism.ku.dk/salary-tax-pension/pension.

Duration: The duration of the positions is 2 years with a possible extension for up-to two years (depending on the performance, and previous employment at the University of Copenhagen).

Application procedure
Your application must be submitted electronically by clicking ‘APPLY NOW’ below.

Your application should include the following documents:

Cover letter. Curriculum vitae, incl. educational qualifications, experience and a list of publications where it shows that the candidates have published at least one publication as first author. A scanned copy of the final degree (PhD or equivalent) certificate. If the degree is not yet awarded, it is sufficient to mention in the cover letter when the applicant expects to submit thesis, and/or receive the qualifying degree. Names and contact details for 2-3 referees.

The applicants can submit these materials in the given fields in the online submission system. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements and that do not have a least one publication as first author.

Deadline for application: May 14, 2019, 23:59 p.m. CET.

After the expiry of the application deadline, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/. For further information about the position or the process or if you experience any technical difficulty with the online submission system, please contact SUND HR: sund-hr-cpr@sund.ku.dk.

CPR and the University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Please apply via recruiter’s website.

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