We are looking for highly motivated and independent postdoctoral fellows to join our team in the laboratory of Dr. Qiao Joe Zhou at Weill Cornell Medical College of Cornell University in NYC. Our laboratory moved from Harvard University to New York in 2019.
Our lab made an exciting discovery that stomach epithelial cells can be readily reprogrammed into functional insulin-secreting cells. One project is focused on reprogramming human stomach stem cells into functional insulin-secreting cells and evaluating their therapeutic potential. In addition, we are studying interactions between gastric insulin+ cells and immune cells to determine how these cells will function in the T1D (Type 1 Diabetes) autoimmune milieu.
A second project is focused on large intestine stem cells. We identified factors that control colon stem cell identity and function. Knockout of these factors can lead to the reprogramming of colon epithelium into small intestine epithelium. We are investigating molecular and epigenetic mechanisms that underlie this dramatic change of stem cell identity. We are also investigating the involvement of these factors in short-bowel disease, inflammatory bowel diseases, and colorectal cancer.
We employ a diverse array of latest technologies in our laboratory including stem cell culture, mouse genetic models, CRSPR-CAS9, single-cell Sequencing, chemical screens, and transplantation.
The candidate should have a PhD or MD degree, a minimum of three years of laboratory experience, and at least one first-author publication that demonstrates proficiency in research. He/she should have vigorous training in at least one of the following fields: stem cell culture, molecular biology, biochemistry, proteomics, drug screening, chemical biology, or mouse genetics.