Salary: Grade 7: Salary in the range £32,236 - £38,460 p.a.
We have an exciting opportunity for a Postdoctoral Researcher in Dr Ester Hammonds research group. Their research is focused on tumour hypoxia and how this impacts treatment response. An overview of the labs research focus, as well as selected recent publications, can be found on the group website (www.rob.ox.ac.uk/research/ester-hammond). A complete list of our publications can be found by searching Pubmed for Hammond_EM.
Recently, we have described the induction of replication stress in response to hypoxia. Importantly, this study demonstrated how the induction/activity of the stress-responsive small subunit of ribonucleotide reductase (RRM2B) ensures that hypoxia-induced replication stress does not result in DNA damage (Foskolou et al., Mol Cell 2017). Despite the absence of DNA damage in hypoxic conditions a robust DNA damage response (DDR) is initiated, which surprisingly includes ATM (Olcina et al., Mol Cell 2013). The role of ATM in the biological response to hypoxia is an active area of research in the Hammond lab. One of the consequences of the hypoxia-induced DDR is p53 activation, we were the first to describe the repression of AKT signalling by hypoxia-induced p53 and subsequent apoptosis (Leszczynska et al., JCI 2015).
The postholder will focus on investigating the hypoxia-induced DNA damage response and, wherever possible, translating this knowledge to improve therapy response. We have carried out a number of RNAseq experiments recently, which are proving highly informative and have generated a number of new research directions for the lab. You will have a PhD (or be nearing completion) in Molecular Biology, Biochemistry, Biology or a related science. Previous experience in the field of tumour hypoxia and/or DNA damage response signalling is essential for this role, along with knowledge of the replication stress response and a high level of technical competence and experience in cell biology methods and techniques.
This is a full-time post and is offered for a fixed-term of 12 months in the first instance.
All applicants must complete an application form and upload a CV and supporting statement.
The closing date for applications is 12.00 noon on Friday 17 May 2019.