Salary: Grade 7: £32,236 - £35,211 p.a.
Are you a recently qualified postdoc with experience of working in cardiovascular pharmaoclogy? This opportunity has arisen in the Department of Pharmacology to work in the lab of Associate Professor Paolo Tammaro on a new 3-year project funded by the British Heart Foundation (BHF).
The project will consider the regulation of cerebral blood flow at the capillary level by the TMEM16A channel. You will investigate: (i) the extent to which TMEM16A in pericytes, and possibly in the surrounding cells of the neurovascular unit (NVU), regulates capillary diameter; (ii) whether TMEM16A participates in pericyte contraction and death in ischaemia, and (iii) if TMEM16A thus constitutes a new therapeutic target in stroke. The post will suit an ambitious and talented individual who is interested in applying his/her skills at the interface of fundamental and applied physiology/pharmacology of the microcirculation.
You will be required to manage your own academic research and administrative activities; adapt existing and develop new scientific techniques and experimental protocols; contribute intellectually to the project, including testing hypotheses and analysing scientific data from a variety of sources; collaborate in the preparation of scientific reports and journal articles; and represent the research group at external meetings/seminars, either with other members of the group or alone.
You should hold, or be close to completing, a PhD/DPhil in physiology, pharmacology or a related discipline and have undertaken training in patch-clamp electrophysiology (especially in acute brain slice preparations) and/or in vivo/ex vivo ion imaging using fluorescent sensors. In addition, you should have sufficient specialist knowledge in the discipline and the ability to develop and refine techniques and experimental approaches. Excellent communication skills are also essentia , including the ability to write for publication, present research proposals and results, and represent the research group at meetings.
The post is offered on a fixed-term basis for 3 years, funded by the BHF. The proposed start date will be 1 June 2019.
The closing date for applications is 12.00 noon on Wednesday 15 May 2019.