Two postdoctoral fellowships (2 years) to study mitochondrial DNA stability with relevance to cancer

Two postdoctoral fellowships (2 years) to study mitochondrial DNA stability with relevance to cancer

Department of Medical Biochemistry and Biophysics, Umeå University

Umeå, Sweden

Up to two postdoctoral fellowships of 2 years each are available to study mechanisms that guarantee mitochondrial DNA stability in eukaryotes. The research will be carried out at the Department of Medical Biochemistry and Biophysics that offers a stimulating international research environment.

Project description
Mitochondria are organelles that produce cellular energy in the form of ATP. The mitochondrion is a unique organelle since it contains multiple copies of a double-stranded circular DNA genome, mtDNA, that encodes for core components of the energy-producing machinery. The mtDNA-encoded subunits are essential for efficient energy production, whereby it is crucial that mtDNA is maintained intact and at a sufficient copy number. Defects in mtDNA maintenance can lead to cellular energy deficiency and manifest as mitochondrial disease. Furthermore, mutations and alterations in mtDNA copy number are implicated in certain cancers. The aim of this project is to characterize the molecular mechanisms that protect mtDNA stability and investigate the connection between mtDNA and the DNA damage response.

We now offer two postdoctoral stipends for 2 years each to study the connection between mtDNA and the DNA damage checkpoints using a combination of human cell culture experiments, yeast genetics and protein biochemistry. The research will be carried out in a young and growing research group funded by the Swedish Society for Medical Research and the Swedish Cancer Society.

Qualifications
The candidate should hold, or be about to be awarded, a PhD degree or equivalent in cell or molecular biology, biochemistry, genetics or a related discipline. We are seeking talented and highly motivated applicants with experience in cell culture experiments, genetics of the yeast Saccharomyces cerevisiae and/or the expression and purification of recombinant proteins. Previous experience in the fields of mitochondrial DNA metabolism or the DNA damage response is a strong merit. An ability to function independently and as part of a team is required. Excellent oral and written communication skills in English are essential.

The application
The application should include:
• a cover letter describing your scientific background and goals for this post-doctoral period (max. one A4 page),
• a CV with full publication list,
• copies of relevant degree certificate(s),
• names and contact information of three reference persons.

Your complete application, in a single pdf-file and marked with reference number FS 2.1.6-195-19, should be sent to medel@diarie.umu.se (state the reference number as subject), before 2019-05-12.

For further information, please contact Paulina Wanrooij at paulina.wanrooij@umu.se and see the lab website at https://www.umu.se/en/research/groups/paulina-wanrooij/

About us
The Department of Medical Biochemistry and Biophysics is located within the Chemical Biological Centre (in Swedish “Kemiskt Biologiskt Centrum”, KBC) – an interdisciplinary research centre for the natural sciences and medicine at Umeå University and the Swedish University of Agricultural Sciences. The centre is unique in its collaborative structure and offers an excellent scientific infrastructure with several core facilities and technical platforms. Our goal is to promote a positive, creative, and interdisciplinary environment for research combined with an excellent graduate and undergraduate education. You can find more information here: www.umu.se/en/kbc.

Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programs, world leading research, and excellent innovation and collaboration opportunities. 4 000 employees and nearly 34 000 students have already chosen Umeå University.

We welcome your application!

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Position

Two postdoctoral fellowships (2 years) to study mitochondrial DNA stability with relevance to cancer