Postdoctoral scholarship on gene regulation and 3D chromatin organisation in glioblastoma

Postdoctoral scholarship on gene regulation and 3D chromatin organisation in glioblastoma

Umeå Center for Molecular Medicine (UCMM), Umeå University

Umeå, Sweden

We are looking for a highly motivated postdoc for a period of two years to study glioblastoma research with special focus on long-range gene regulation and 3D chromatin organisation.

This scholarship is funded by the Wallenberg Centre for Molecular Medicine (WCMM) at Umeå University. WCMM was established as part of a national effort by Knut and Alice Wallenberg Foundation (KAW) to strengthen life science-research in Sweden. WCMM at Umeå University shares a close collaboration with the County Council of Västerbotten, the other WCMM centres in Sweden and SciLifeLab.

The research group is positioned at Umeå Center for Molecular Medicine (UCMM) at Umeå University. At the department, strong research is conducted in the fields of neuroscience, cancer, genetics, metabolism and imaging. The center is well equipped with the instrumentation and resources required, as well as access to different core facilities. In the laboratory there is a strong background in gene regulation and 3D chromatin organisation, mouse genetics and basic cancer research. We are looking for an enthusiastic and motivated postdoc to study the contribution of the regulatory genome to glioblastoma in Silvia Remeseiro’s research group.

Project description
Glioblastoma is the most lethal and aggressive, but also the most common, of all primary brain tumors. Most genetic variants that predispose to cancer are located in non-coding regions enriched in putative enhancers, whose systematic rearrangements have a high impact on gene expression in cancer. Despite the number of susceptibility loci identified in glioblastoma, a functional understanding of how the non-coding regulatory genome contributes to the pathogenesis is missing.

We are interested in how the reprogramming of regulatory regions and topological changes in 3D chromatin organisation determine gene dysregulation in glioblastoma, and how this subsequently contributes to malignancy, heterogeneity and invasiveness.

The big framework of the project will employ next generation sequencing approaches, genome editing and live-cell imaging in both glioblastoma mouse models and human glioma cell lines; with the main focus on studying how the regulatory and topological architecture of the genome influences malignancy and integrates cues from the neurons in the tumor microenvironment to orchestrate gene expression in glioblastoma.

Experimental methodology includes different next generation sequencing approaches (HiC/4C-seq, ChIP-seq, RNA-seq, ATAC-seq), bioinformatics analysis and/or microscopy (live-cell imaging, in vivo imaging). The scholarship also requires work with mouse models and/or cell lines in culture and genome editing (CRISPR/Cas9). The successful candidate must be able to: 1) independently plan experiments, 2) conduct research within the framework of the group’s research program, 3) establish methods, 4) conduct data analysis, 5) communicate results and present data at national and international scientific meetings.

Qualifications
Candidates must hold a PhD degree equivalent to a European University PhD at the time of recruitment in the field of molecular medicine or related disciplines. A strong background in molecular biology and genomics and/or imaging is required. To be eligible the degree should have been completed a maximum of three years before the end of the application period unless special circumstances exist.
We are looking for a highly talented and curious researcher with independent and critical thinking, with a record of productive research and the ability to work independently as well as part of a team.
Experience with HiC/4C-seq, ChIP-seq, RNA-seq, ATAC-seq and/or CRISPR/Cas9 technology are highly desirable skills. Documented experience in laboratory animals management is desirable but not a requirement. Previous background in bioinformatics, neuroscience and/or glioblastoma are a merit. Publications in the areas of gene regulation, 3D chromatin organisation and/or oncology are meriting. Excellent oral and written English communication skills are required.

The scholarship is fully covered for 2 years but the candidate will also be encouraged to apply for her/his own grants.

Selection criteria
In particular, applicants who have completed a doctoral degree no more than three years before the application deadline are considered. In special circumstances, an earlier doctoral degree may be considered. Special circumstances refer to leave due to illness, parental leave or clinical service, trust assignments within trade union organizations or similar.

Application
The application shall include the following documents:

- Cover letter: a short description of your research interests and why you are interested in the scholarship (max one page).
- Curriculum vitae (CV) including previous positions, publications list and technical skills.
- Copies of diplomas.
- Contact information for two references.

Your complete application, marked with reference number FS 2.1.6-728-19, should be sent to medel@diarie.umu.se (state the reference number as subject), by 2019-05-10 at the latest.

Additional information
For further information, please contact Assistant Professor Silvia Remeseiro, UCMM / WCMM, at silvia.remeseiro@umu.se

www.ucmm.umu.se
www.wcmm.umu.se

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Postdoctoral scholarship on gene regulation and 3D chromatin organisation in glioblastoma