Salary: Grade 7: Salary in range £32,236 - £39,609 pro rata per annum
Applications are invited for a Postdoctoral Research Scientist in Genome Stability Research to join the Genome Integrity group headed by Associate Professor Ross Chapman. The teams research aims to understand the context-specificity of DNA double-stranded break (DSB) repair systems, and the regulatory mechanisms that allow DSBs to be appropriately channelled to both accurate, and mutagenic repair outcomes between different tissues and cellular contexts.
The group is looking to recruit a talented, enthusiastic, and collaborative post-doctoral scientist to develop an innovative and competitive research project to gain a mechanistic understanding of the 53BP1-dependent NHEJ pathway, its downstream protein components (see Ghezraoui et al. Nature 2018), and its antagonism by the BRCA1 tumour suppressor pathway. Experimental approaches are likely to include protein interaction studies, mutational protein analyses, CRISPR-Cas9 engineering/screening, and developing and analyzing in vivo models to study the impact of DNA repair mechanisms and/or deficits in mammalian physiology and cancer.
You will have a PhD (or near completion) in genome stability biology, biochemistry, molecular immunology, cancer biology or allied discipline, with a track record in working independently to formulate and experimentally test original research hypotheses. You should be a competitive candidate for external funding in the form of fellowship support or project funding, and have an excellent publication record relative to career stage, with lead author publications in leading refereed journals, and presentations of papers at international conferences, or equivalent. You will also have demonstrable expertise in molecular biology, mammalian tissue culture, functional cellular assays and general biochemical and cell-biology techniques. Candidates with a strong track record in genome-wide screens and/or protein purification and biochemistry related to DNA metabolism biology are also encouraged to apply.
Working as part of a team, you will manage the day-to-day running of a research project including assisting the work of junior researchers and research assistants, and managing resources effectively.
The position is funded by Medical Research Council and is fixed term until 5th July 2021 in the first instance.
Please quote ref. 140242 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.
Only applications received before 12.00 midday on Wednesday 8 May 2019 will be considered.