Clinical Research Fellow in Motor Neuron Disease

Nuffield Department of Clinical Neurosciences, University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade E64: £32,569 - £52,200 p.a.

The Nuffield Department of Clinical Neurosciences seeks an enthusiastic Clinical Research Fellow for the opportunity to develop their expertise in Motor Neurone Disease (MND, also known as Amyotrophic Lateral Sclerosis, ALS, and the related disorder frontotemporal dementia, FTD) through their engagement with an established internationally-leading programme of neuroscience research led by Professor Martin Turner and Professor Kevin Talbot.


The post will function within an established program for the multimodal, longitudinal study of patients with MND (A Multicentre Biomarker Study in ALS/AMBRoSIA). The post involves the prospective collection of clinical data (including cognitive assessment), genetic, neurochemical, MRI, MEG, and basic oculomotor profiles of those suspected to have MND, those at genetic risk of MND, those with conditions that mimic MND, and healthy controls.


The postholder will be required to develop an individual project suited to their particular skills and interests, and the priorities of the research group. The postholder may choose to focus on neurochemical (proteomics), or neuroimaging analysis (pharmacodynamic studies using MRI and MEG), or in vivo or in vitro models of disease using mice and iPSC-derived human motor neurons, with the aim of furthering understanding of the basic pathogenesis of MND.


A medical degree and full GMC registration is essential, as is an academic interest in neurodegeneration, particularly MND and its overlap with FTD. The postholder will be required to demonstrate sufficient specialist knowledge in neurology to work with MND patients and carers. A willingness to continually update knowledge in the specialist area, with excellent organisational skills, motivation and effective interpersonal skills are essential to this position. This post would be particularly suitable for those wishing to undertake a DPhil in neurodegeneration research.


The post is full-time for a fixed-term until 31 August 2020 in the first instance.


Only applications received before 12.00 midday on 13 May 2019 will be considered. Interviews will be held as soon as possible thereafter.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-140254

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