Postdoctoral Fellow

Postdoctoral Fellow

Max Planck Florida Institute for Neuroscience (MPFI)

Jupiter, FL, United States

A postdoctoral position is available working in the laboratory of Hiroki Taniguchi

Ph.D., a research group leader at the Max Planck Florida Institute (MPFI). Our

research focus is on understanding development and plasticity of inhibitory

interneuron subtypes (see below). We are looking for highly motivated

individuals who will enjoy the process to achieve a unique science and have a

strong ambition to create trends of neural circuit research in the future.

The MPFI in Jupiter, Florida is the first institute established by Germany’s

prestigious Max Planck Society outside of Europe. The research focus of the

MPFI is structure and function of neural circuits, the complex synaptic networks

of the brain. The MPFI has had a lot of exciting seminars presented by worldrenowned

researchers, and a close relationship with the Scripps Florida Institute

and Florida Atlantic University on the same campus. To be able to feel Max

Planck spirits in US is another advantage in our institute.

(Research Topics)

Cortical inhibitory interneurons (INs) display diverse subtypes, which innervate

distinct compartments (e.g., dendrites, somata, and axon initial segments) of

excitatory principal neurons (PNs) and regulate various types of circuit operations.

We have been interested in elucidating subtype-specific IN development and

plasticity. To address these questions, we employ mouse genetics, molecular

biology, virology, and imaging techniques. We are working on following projects.

1) Molecular mechanisms underlying specification and circuit formation of

chandelier cells (ChCs), which powerfully control action potential generation in

PNs by innervating their axon initial segments. We have already identified

several candidate genes that are preferentially expressed in ChCs. We are

analyzing the function of these genes in vivo. We have also begun to be

interested in the chromatin dynamics during cell type specification.

2) We have developed a novel genetic strategy, which enables us to label and

manipulate IN subtypes sending inputs to PN subtypes. We will determine the

spatial organization and function of IN subtypes in cortical microcircuits. We will

also elucidate mechanisms underlying the organization of IN subtypes

innervating area- and layer-specific PNs.

3) The role and molecular mechanisms of structural plasticity in cortical

interneurons.

(References)

Taniguchi et al.,Neuron, 2011

Taniguchi et al.,Science, 2013

Taniguchi et al.,Front. Cell. Neurosci, 2014

Ishino et al., Journal of Neuroscie, 2017

Steinecke et al., eNeuro, 2017

Yetman et al., Nature Neuroscience, 2019

(Location)

Max Planck Florida Institute, Jupiter, Florida, USA.

Jupiter is located in south Florida and surrounded by a lot of nature.

There are many good school districts within the area.

It is warm throughout the year. It must be good for family.

(Qualification)

Applicants must have or be expected to receive a Ph.D.

Experience in in vivo imaging, molecular biology, chromatin biology, and in utero

electroporation is preferred but not necessary.

(Salary and benefits)

In accordance with MPFI regulations

(Start of employment)

In early 2019 (negotiable but ASAP)

(Application and required documents)

1. Complete CV including a publication list, experimental skills and contact

information on 3 reference persons

2. Description of current and previous research summary (1-2 page)

3. Description of the reason why you apply and what you want to do (1-2 page)

A PDF should be sent to Hiroki Taniguchi, Ph.D. via e-mail.

Contact prior to application is welcome.

E-mail: taniguchimpfi@gmail.com

Tel: 1-561-972-9260

Please apply via recruiter’s website.

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