Postdoctoral Fellows in Hematological Malignancies and Cancer Immunology

Postdoctoral Fellows in Hematological Malignancies and Cancer Immunology

Fox Chase Cancer Center

Philadelphia, PA, United States

Postdoctoral Fellows in Hematological Malignancies and Cancer Immunology


School: Program in Blood Cell Development and Function, Fox Chase Cancer Center, Philadelphia, PA


Description: We are seeking highly motivated and enthusiastic PhD or MD/PhD scientists to fill in two positions as post-doctoral research fellows.


1. The Sykes Lab (website: https://www.foxchase.org/stephen-sykes)focuses on identifying and targeting molecular pathways that support the pathogenesis of acute myeloid leukemia (AML) but are dispensable for healthy hematopoietic stem and progenitor cell function. We are currently focused on elucidating the roles for pathways that help AML cells navigate stresses such as chemotherapy. As such, we are currently looking for post-doctoral fellows that have expertise in:

·        Stress-related signal transduction

·        Amino acid and glucose metabolism

·        Lipid metabolism

·        Acute myeloid leukemia and/or hematopoietic stem cell biology


2. The Yang lab (website: https://www.foxchase.org/yibin-yang) mainly focuses on pursuing a new understanding of immune regulatory mechanisms in human lymphoid malignancies, with a particular interest in ubiquitin-mediated signaling pathways in lymphoma pathogenesis and immunotherapy. We are using unbiased high throughout CRISPR library screening technology to rapidly and accurately identify key pathways that are suitable for targeted therapy and immunotherapy. We seek a postdoctoral fellow to join our efforts to apply multidisciplinary cutting-edge approaches to further our understanding of the immune regulatory mechanisms in lymphoma. The individual will engage in experiments involving CRISPR library screening, immunotherapy, next-generation sequencing, gene expression (RNA-seq), biochemical analysis, and eventually exploiting targeted and immunotherapy for human lymphoid malignancies. This is a unique opportunity for someone with expertise in biochemistry/molecular biology and next generation sequencing techniques to learn complementary skills and become proficient in translational study.

The candidate must have excellent skills in biochemistry and molecular biology, and ideally with experiences in post-translational protein modifications. Knowledge and expertise in cancer biology and/or immunology and experience in high quality flow cytometry-based assays, tissue culture, RNA-seq, cytokine multiplex assays and ELISA, next-generation sequencing are desirable. He/she will be required to be highly motivated with a strong passion for research and with good communication skills in English.


Contact: Please forward a cover letter describing your career plans, updated CV and the names/contact information for 3 professional references to:


Position 1:

Stephen M. Sykes, PhD

Assistant Professor

Program in Blood Cell Development and Function

Fox Chase Cancer Center

Email: Stephen.Sykes@fccc.edu


Position 2:

Yibin Yang, PhD

Assistant Professor

Program in Blood Cell Development and Function

Fox Chase Cancer Center

E-mail: yibin.yang@fccc.edu

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Postdoctoral Fellows in Hematological Malignancies and Cancer Immunology