Salary: Grade 6: £28,660 - £34,189 p.a.
A Prostate Cancer UK-funded position as Research Assistant is available immediately in the laboratory of Dr Valentine Macaulay in the Department of Oncology on the Old Road Campus, Headington, Oxford. This is a full-time post funded by Prostate Cancer UK, fixed-term for 3 years in the first instance.
The postholder will investigate the involvement of the insulin-like growth factor (IGF) axis in the progression of early prostate cancer. This role will suit highly-motivated applicants with an interest in growth factor signalling and prostate cancer biology, and ability to work with care, enthusiasm and scientific rigor.
This project aims to understand how circulating IGF-1 is linked to risk of prostate cancer, by investigating effects of IGF blockade in in vitro and in vivo models. You will collect blood and tissue samples to study effects of blocking IGFs on the tumour, tumour microenvironment and host, including analysis at proteomic and transcriptomic levels. Depending on progress, there may also be an opportunity to conduct parallel investigations on samples from prostate cancer patients undergoing treatment with anti-IGF antibody. This will require the appointee to work with clinicians and scientists to collect, inventorise, process and analyse biological samples. Based on the outcomes of these analyses, you will be encouraged to develop and investigate your own hypotheses. Your personal scientific development will be actively encouraged.
The successful candidate will be required to undertake detailed planning of bench-work, perform and analyse experiments, liaise with collaborators and write progress reports. There will also be an element of laboratory management, including managing laboratory stocks and maintaining inventories. Therefore, you will need to be highly responsible and able to manage conflicting priorities and tight deadlines. You will have an undergraduate degree in cancer biology, biochemistry, molecular biology or a related field. You will also have expertise in standard cell and molecular biology techniques, microscopy and immunohistochemistry, and experience with in vivo models, ideally with own Personal Licence. Previous experience of combining the roles of Research Assistant and Laboratory Manager will be useful, together with a good understanding of IGF signalling and cancer biology.
For more information, please contact Dr Macaulay using the email address below.
All applicants must complete an application form and will be required to upload a CV and supporting statement.
The closing date for applications is 12.00 noon on Friday 3 May 2019.