Laboratory Research Scientist

Laboratory Research Scientist

The Francis Crick Institute

London, United Kingdom

Job title: Laboratory Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Contract: Fixed-term (4 years), full-time

Salary: From £33,500 per annum, subject to skills and experience

Vacancy ID: 101366

Short summary

This is an exciting opportunity funded by the ERC to join our international team of scientists working on the molecular and cellular basis of tuberculosis infection. Our work aims to improve our knowledge of how the bacterium that causes tuberculosis, Mycobacterium tuberculosis, survives within human cells avoiding our immune system and, on the other hand, the mechanisms that human cells have to kill mycobacteria.

We are looking for curious and motivated scientists, with a strong background in stem cell biology (iPS), interested in developing genetic tools in human stem cells to visualize their interactions using cutting-edge imaging technologies. This is a role to provide technical support to the team, as well as develop new methods and tools independently.

Project scope

The position is part of a research project funded by the European Research Council (ERC) that aims to develop genetic and imaging tools to better understand the complex interactions between M. tuberculosis and human macrophages.

The specific aims for this project are to develop fluorescent reporters and genetically modified human induced pluripotent stem-cell (iPSC)-derived macrophages (iPSDM) by using CRISPR/Cas9 gene editing. These tools will be used in combination with single-cell imaging methods within engineered environments.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

  • If you are interested in applying for this role, please apply via our website.
  • The closing date for applications is 25 April 2019 at 23:30.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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